scholarly journals Macrovascular Networks on Contrast-Enhanced Magnetic Resonance Imaging Improves Survival Prediction in Newly Diagnosed Glioblastoma

Cancers ◽  
2019 ◽  
Vol 11 (1) ◽  
pp. 84 ◽  
Author(s):  
Josep Puig ◽  
Carles Biarnés ◽  
Pepus Daunis-i-Estadella ◽  
Gerard Blasco ◽  
Alfredo Gimeno ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Prediction Models ◽  
Survival Prediction ◽  
Dynamic Susceptibility ◽  
Imaging Features ◽  
Newly Diagnosed ◽  
Resonance Imaging ◽  
Contrast Enhanced ◽  
Newly Diagnosed Glioblastoma

A higher degree of angiogenesis is associated with shortened survival in glioblastoma. Feasible morphometric parameters for analyzing vascular networks in brain tumors in clinical practice are lacking. We investigated whether the macrovascular network classified by the number of vessel-like structures (nVS) visible on three-dimensional T1-weighted contrast–enhanced (3D-T1CE) magnetic resonance imaging (MRI) could improve survival prediction models for newly diagnosed glioblastoma based on clinical and other imaging features. Ninety-seven consecutive patients (62 men; mean age, 58 ± 15 years) with histologically proven glioblastoma underwent 1.5T-MRI, including anatomical, diffusion-weighted, dynamic susceptibility contrast perfusion, and 3D-T1CE sequences after 0.1 mmol/kg gadobutrol. We assessed nVS related to the tumor on 1-mm isovoxel 3D-T1CE images, and relative cerebral blood volume, relative cerebral flow volume (rCBF), delay mean time, and apparent diffusion coefficient in volumes of interest for contrast-enhancing lesion (CEL), non-CEL, and contralateral normal-appearing white matter. We also assessed Visually Accessible Rembrandt Images scoring system features. We used ROC curves to determine the cutoff for nVS and univariate and multivariate cox proportional hazards regression for overall survival. Prognostic factors were evaluated by Kaplan-Meier survival and ROC analyses. Lesions with nVS > 5 were classified as having highly developed macrovascular network; 58 (60.4%) tumors had highly developed macrovascular network. Patients with highly developed macrovascular network were older, had higher volumeCEL, increased rCBFCEL, and poor survival; nVS correlated negatively with survival (r = −0.286; p = 0.008). On multivariate analysis, standard treatment, age at diagnosis, and macrovascular network best predicted survival at 1 year (AUC 0.901, 83.3% sensitivity, 93.3% specificity, 96.2% PPV, 73.7% NPV). Contrast-enhanced MRI macrovascular network improves survival prediction in newly diagnosed glioblastoma.

scholarly journals Diagnostic Value of Semiquantitative Analysis of Dynamic Susceptibility Contrast Magnetic Resonance Imaging with GD-EOB-DTPA in Focal Liver Lesions Characterization: A Feasibility Study

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Davide Ippolito ◽  
Maddalena Colombo ◽  
Chiara Trattenero ◽  
Pietro Andrea Bonaffini ◽  
Cammillo Talei Franzesi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Focal Liver Lesions ◽  
Dynamic Susceptibility ◽  
Liver Lesions ◽  
Resonance Imaging ◽  
Dynamic Susceptibility Contrast ◽  
Contrast Enhanced ◽  
Malignant Lesions ◽  
Susceptibility Contrast

Purpose.To assess the diagnostic accuracy of dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSCE-MRI) in differentiation between benign and malignant liver lesions by assessment of tumoral perfusion parameters.Methods Materials.Seventy-three patients with known focal liver lesions, including 45 benign (16 FNH, 27 angiomas, and 2 abscesses) and 28 malignant ones (17 metastases, 9 HCCs, and 2 cholangiocarcinoma) underwent 1.5 T MRI upper abdominal study, with standard protocol that included dynamic contrast-enhanced sequences. On dedicated workstation, time-intensity curves were determined and the following perfusion parameters were calculated: relative arterial, venous and late enhancement (RAE, RVE, RLE), maximum enhancement (ME), relative enhancement (RE), and time to peak (TTP).Results.All diagnoses were established either by histopathology or imaging follow-up. Perfusion mean values calculated in benign lesions were RAE 33.8%, RVE 66.03%, RLE 80.63%, ME 776.00%, MRE 86.27%, and TTP 146.95 sec. Corresponding perfusion values calculated in malignant lesions were RAE 22.47%, RVE 40.54%, RLE 47.52%, ME 448.78%, MRE 49.85%, and TTP 183.79 sec. Statistical difference (p<0.05) was achieved in all the perfusion parameters calculated, obtaining different cluster of perfusion kinetics between benign and malignant lesions.Conclusions.DSCE-MRI depicts kinetic differences in perfusion parameters among the different common liver lesions, related to tumour supply and microvascular characteristics.

Multiparametric ultrasound imaging characteristics of multiple testicular adrenal rest tumours in congenital adrenal hyperplasia

Ultrasound ◽  
2021 ◽  
pp. 1742271X2198908
Author(s):  
Nina M Mansoor ◽  
Dean Y Huang ◽  
Paul S Sidhu
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Congenital Adrenal Hyperplasia ◽  
Imaging Features ◽  
Adrenal Hyperplasia ◽  
Resonance Imaging ◽  
Colour Doppler ◽  
Imaging Characteristics ◽  
Contrast Enhanced ◽  
Adrenal Rest

Introduction Testicular adrenal rest cell tumours (TART) are rare benign adrenocorticotropic hormone-dependent testicular tumours, which can develop in patients with congenital adrenal hyperplasia. If left untreated, they can cause testicular tissue damage and infertility. Ultrasound is the imaging modality of choice allowing for non-invasive diagnosis provided that characteristic features are seen. In recent times, magnetic resonance imaging characteristics have also been described to aid diagnosis. Case Report This case describes the imaging features of multiple bilateral TART in a young patient with congenital adrenal hyperplasia. Traditional greyscale and colour Doppler ultrasound demonstrated intratesticular, predominantly hypoechoic areas, with increased surrounding colour Doppler flow. In addition, contrast-enhanced ultrasound and strain elastography were performed, showing increased TART vascularisation and increased stiffness in the hypoechoic areas. Subsequent magnetic resonance imaging confirmed bilateral lobulated, well demarcated, intratesticular lesions, which appeared predominantly isointense on T1-weighted imaging, hypointense on T2-weighted imaging, with heterogeneous enhancement following gadolinium administration. Discussion This case illustrates the sonographic features including greyscale, colour Doppler, contrast and elastography ultrasound of TART in a patient with congenital adrenal hyperplasia. Both contrast-enhanced ultrasound and elastography can provide information about tissue properties not normally derived from conventional ultrasound and aid accurate diagnosis. Additional magnetic resonance imaging is not normally required with typical ultrasound appearances. The unusual findings seen on the ultrasound examination were likely secondary to poor compliance with treatment. Conclusion Familiarity and recognition of characteristic and uncommon imaging features of these tumours are important to avoid misdiagnosis and surgical intervention.

scholarly journals Magnetic Resonance Imaging features of breasts in patients

1970 ◽  
Vol 34 (2) ◽  
pp. 44-47 ◽  
Author(s):  
Shahnaz Choudhury ◽  
Ichiro Isomoto ◽  
Kuniaki Hyashi
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Potential Role ◽  
Nipple Discharge ◽  
Imaging Features ◽  
Resonance Imaging ◽  
Histopathological Correlation ◽  
Contrast Enhanced ◽  
Highly Sensitive

A retrospective study was conducted to demonstrate the potential role of dynamic contrast enhanced magnetic resonance imaging (DCEMRI) in the detection of breast lesions in 15 patients with nipple discharge. The DCEMRI findings were compared and correlated with the findings of ultrasonography and mammography. The results revealed that the character of the nipple discharge was mostly bloody and in few cases were serous. The imaging findings revealed that DCEMRI is highly sensitive and specific in the detection of breast canner and the histopathological correlation in such detection was highly significant (p<0.001) as compared to ultrasonography and mammography finding.Keywords: Magnetic Resonance Imaging; BreastDOI: 10.3329/bmrcb.v34i2.1174Bangladesh Med Res Counc Bull 2008; 34: 44-47

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