scholarly journals Endogenously-Activated Ultrasmall-in-Nano Therapeutics: Assessment on 3D Head and Neck Squamous Cell Carcinomas

Cancers ◽  
2020 ◽  
Vol 12 (5) ◽  
pp. 1063 ◽  
Author(s):  
Melissa Santi ◽  
Ana Katrina Mapanao ◽  
Domenico Cassano ◽  
Ylea Vlamidis ◽  
Valentina Cappello ◽  
...  

Negative or positive HPV-associated Head and Neck Squamous Cell Carcinomas (HNSCCs) are high recurrence neoplasms usually resulting in a poor prognosis, mainly due to metastasis formation. Despite the low overall patient survival rate and the severe side effects, the treatment of choice is still cisplatin-based chemotherapy. Here, we report a straightforward protocol for the production of high throughput 3D models of negative or positive HPV-associated HNSCCs, together with their employment in the therapeutic evaluation of gold ultrasmall-in-nano architectures comprising an endogenously-activatable cisplatin prodrug. Beyond enhancing the biosafety of cisplatin, our approach paves the way for the establishment of synergistic co-therapies for HNSCCs based on excretable noble metals.

2008 ◽  
Vol 134 (12) ◽  
pp. 1267-1276 ◽  
Author(s):  
Davut Pehlivan ◽  
Esra Gunduz ◽  
Mehmet Gunduz ◽  
Hitoshi Nagatsuka ◽  
Levent Bekir Beder ◽  
...  

Head & Neck ◽  
2006 ◽  
Vol 28 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Tibor Görögh ◽  
Ulf H. Beier ◽  
Jens Bäumken ◽  
Jens E. Meyer ◽  
Markus Hoffmann ◽  
...  

Author(s):  
Melissa Santi ◽  
Ana Katrina Mapanao ◽  
Lorenzo Biancalana ◽  
Fabio Marchetti ◽  
Valerio Voliani

Oncotarget ◽  
2011 ◽  
Vol 2 (12) ◽  
pp. 1165-1175 ◽  
Author(s):  
Daniela Gasparotto ◽  
Jerry Polesel ◽  
Alessandra Marzotto ◽  
Roberta Colladel ◽  
Sara Piccinin ◽  
...  

1998 ◽  
Vol 23 (3) ◽  
pp. 268-269
Author(s):  
Liloglou ◽  
Scholes ◽  
Spandidos ◽  
Jones ◽  
Vaughan ◽  
...  

2005 ◽  
Vol 14 (2) ◽  
pp. 320-321
Author(s):  
Mehmet Gunduz ◽  
Esra Gunduz ◽  
Byung-Moo Min ◽  
Gene Lee ◽  
Ji-Jun Lim ◽  
...  

Oral Oncology ◽  
2011 ◽  
Vol 47 ◽  
pp. S46
Author(s):  
F.K.J. Leusink ◽  
P.J. Slootweg ◽  
M.W.M. van den Brekel ◽  
R.J. Baatenburg de Jong ◽  
F.C.P. Holstege ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document