scholarly journals Impact of Tumor Site and Adjuvant Radiotherapy on Survival of Patients with Adenoid Cystic Carcinoma: A SEER Database Analysis

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 589
Author(s):  
Jason Tasoulas ◽  
Kimon Divaris ◽  
Stamatios Theocharis ◽  
Douglas Farquhar ◽  
Colette Shen ◽  
...  
Keyword(s):  
Overall Survival ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Adjuvant Radiotherapy ◽  
Clinicopathological Parameters ◽  
Seer Database ◽  
Adenoid Cystic ◽  
Mechanistic Investigation ◽  
The Impact

Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor, displaying aggressive behavior with frequent recurrence and metastasis. Little information exists regarding the impact of clinicopathological parameters and adjuvant radiotherapy (aRT) on ACC disease specific (DSS) and overall survival (OS). We extracted demographic, treatment, and survival information of 1439 patients with major or minor intraoral salivary gland ACC from the Surveillance, Epidemiology, and End Results (SEER) database. The associations between tumor characteristics and aRT with OS and DSS were estimated using hazard ratios (HR) and 95% confidence intervals (CI). Submandibular gland ACCs had the worst prognosis (adjusted DSS HR = 1.48; 95% CI = 0.99–2.20, compared to parotid), and this difference was more pronounced among patients with advanced-stage tumors (adjusted DSS HR = 1.93; 95% CI = 1.13–3.30). aRT was associated with increased overall survival only among stage III submandibular ACC patients (HR = 0.64; 95% CI = 0.42–0.98) and had no benefit in any other group. In conclusion, submandibular gland ACC carries a worse prognosis than other gland subsites and may benefit from aRT. The different outcomes between submandibular gland and other major or minor gland ACCs warrant further mechanistic investigation.

Two malignant salivary gland tumours of different type in one patient

1994 ◽  
Vol 108 (9) ◽  
pp. 798-800 ◽  
Author(s):  
A. Hosni ◽  
C. Fisher ◽  
P. Rhŷ-Evans
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Submandibular Gland ◽  
Histological Type ◽  
Salivary Gland Tumours ◽  
Adenoid Cystic ◽  
The Right ◽  
Left Parotid Gland

AbstractThe synchronous or metachronous occurrence of two tumours of the salivary glands in one patient is rare. These are mainly benign and of the same histological type. Here we report a 56-year-old man who developed a mucoepidermoid tumour of the left parotid gland four years after diagnosis of adenoid cystic carcinoma of the right submandibular gland. This combination of neoplasms has not to our knowledge been reported before.

scholarly journals Analysis of Ki-67 expression as clinicopathological parameters in predicting the prognosis of adenoid cystic carcinoma

2017 ◽  
Vol 50 (4) ◽  
pp. 205
Author(s):  
Silvi Kintawati ◽  
Murnisari Darjan ◽  
Winny Yohana
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Cellular Proliferation ◽  
Salivary Gland Tumor ◽  
Clinicopathological Parameters ◽  
Clinical Parameters ◽  
Ki 67 ◽  
Term Survival ◽  
Adenoid Cystic ◽  
Histopathological Grading

Background: Adenoid cystic carcinoma is a malignant salivary gland tumor located in the head and neck region. Although complete surgical resection and complementary radiotherapy have been shown to improve long-term survival rates, the prognosis of adenoid cystic carcinoma remains poor. Ki-67 expression is considered a marker for the cellular proliferation rate, the detection of its expression usually being related to the aggressiveness and unfavorable prognosis of adenoid cystic carcinoma in the salivary gland. Purpose: This study was conducted to quantify the expression of Ki-67 in adenoid cystic carcinoma and to correlate the result with clinical parameters and histopathological grading in determining the prognosis. Methods: Twenty three cases of salivary gland adenoid cystic carcinoma were identified at the Department of Anatomical Pathology, Dr. Hasan Sadikin Hospital between 2013 and 2015. Clinical data such as age, gender, location of tumor and histopathological grading was also collected. The expression of Ki-67 was assessed by immunohistochemical means to determine the correlation of Ki-67 with clinical parameters and histopathological grading. Results: There were no significant differences between the expression of Ki-67 and clinical parameters, although a very strong correlation existed between the expression of Ki-67 and histopathological grading (p < 0.01). Conclusion: There were no correlation between the expression of Ki-67 and clinical parameters, although a correlation existed between the expression of Ki-67 and histopatological grading in salivary gland adenoid cystic carcinoma. Thus, clinical parameters were unusable in determining the prognosis of adenoid cystic carcinoma, although Ki-67 expression could be used for this purpose.

Adenoid cystic carcinoma of the sublingual salivary gland in a 16-year-old female – report of a case and review of the literature

1997 ◽  
Vol 111 (5) ◽  
pp. 485-488 ◽  
Author(s):  
M. R. McFall ◽  
G. H. Irvine ◽  
J. W. Eveson
Keyword(s):  
Salivary Gland ◽  
Case Report ◽  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Review Of The Literature ◽  
Present Case Report ◽  
Adenoid Cystic ◽  
Wharton’S Duct

AbstractTumours of the sublingual salivary gland are exceptionally rare. The present case report describes an adenoid cystic carcinoma of the sublingual salivary gland occurring in a 16-year-old girl, in itself an uncommon event. In addition, an interesting feature of the presentation was obstruction of the ipsilateral submandibular gland due to involvement of Wharton's duct.

The impact of molecular profiling guided targeted gold nanoparticles on radiosensitivity of metastatic salivary gland adenoid cystic carcinoma.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. e17558-e17558
Author(s):  
Aron Popovtzer ◽  
Inbal Hazkany ◽  
Izhak Haviv ◽  
Dimitry Bragilovski ◽  
Baruch Brenner ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Molecular Profiling ◽  
Adenoid Cystic ◽  
The Impact

scholarly journals Impact of tumour site and adjuvant radiotherapy on survival in adenoid cystic carcinoma: A SEER database analysis

2019 ◽  
Vol 30 ◽  
pp. v465
Author(s):  
Jason Tasoulas ◽  
Kimon Divaris ◽  
Stamatios Theocharis ◽  
Douglas Farquhar ◽  
Trevor Hackman ◽  
...  
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Adjuvant Radiotherapy ◽  
Seer Database ◽  
Tumour Site ◽  
Database Analysis ◽  
Adenoid Cystic

scholarly journals A Rare Variety of Adenoid Cystic Carcinoma involving Submandibular Salivary Gland

2015 ◽  
Vol 23 (2) ◽  
pp. 77-80
Author(s):  
Sanjoy Kumar Ghosh ◽  
Saikat Samaddar ◽  
Swagatam Banerjee ◽  
Diptanshu Mukherjee
Keyword(s):  
Salivary Gland ◽  
Adenoid Cystic Carcinoma ◽  
Submandibular Gland ◽  
Histopathological Examination ◽  
Salivary Gland Neoplasm ◽  
Submandibular Salivary Gland ◽  
Cell Adenoma ◽  
Adenoid Cystic ◽  
Benign Adenoma ◽  
Solid Variety

IntroductionAdenoid cystic carcinoma, an uncommon malignant salivary gland neoplasm, is known for its long clinical course, indolent growth, neural invasion, local recurrence and late distant metastasis. Three distinct histological patterns have been identified, amongst which, solid pattern is the rarest one having the worst prognosis. Materials And MethodsA case of sixty year old male patient presented with a swelling in the left side of the neck, below the jaw gradually enlarging during the last three years. FNAC from the neck swelling was suggestive of benign adenoma of the salivary gland, possibly basal cell adenoma or pleomorphic adenoma. Submandibular gland was excised. Histopathological examination confirmed the solid pattern of adenoid cystic carcinoma, which is the rarest among the three distinct histological subtypes of the malignancy. DiscussionAdenoid cystic carcinoma is well known for its perineural spread. In cases of submandibular gland adenoid cystic carcinoma, surgical wide excision is very much possible and in T1 or T2 cases post-operative radiotherapy may not be needed. In our case, post operative radiotherapy was given for best local control, as the tumour showed histopathlogical solid variety, grade III pattern, which is known to have the worst prognosis.

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