scholarly journals Current Trends in Endoscopic Diagnosis and Treatment of Early Esophageal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 752
Author(s):  
Franz Ludwig Dumoulin ◽  
Ralf Hildenbrand ◽  
Tsuneo Oyama ◽  
Ingo Steinbrück

Diagnosis of esophageal adenocarcinoma mostly occurs in the context of reflux disease or surveillance of Barrett’s metaplasia. Optimal detection rates are obtained with high definition and virtual or dye chromoendoscopy. Smaller lesions can be treated with endoscopic mucosal resection. Endoscopic submucosal dissection (ESD) is an option for larger lesions. Endoscopic resection is considered curative (i.e., without significant risk of lymph node metastasis) if histopathology confirms en bloc and R0 resection of a well-differentiated (G1/2) tumor without infiltration of lymphatic or blood vessels and the maximal submucosal infiltration depth is 500µm. Ablation of remaining Barrett’s metaplasia is important, to reduce the risk of metachronous cancer. Esophageal squamous cell cancer is associated with different risk factors, and most of the detected lesions are diagnosed during upper gastrointestinal endoscopy for other indications. Virtual high definition and dye chromoendoscopy with Lugol’s solution are used for screening and evaluation. ESD is the preferred resection technique. The criteria for curative resection are similar to Barrett’s cancer, but the maximum infiltration depth must not exceed lamina propria mucosae. Although a submucosal infiltration depth of up to 200 µm carries a substantial risk of lymph node metastasis, ESD combined with adjuvant chemo-radiotherapy gives excellent results. The complication rates of endoscopic resection are low, and the functional outcomes are favorable compared to surgery.

Surgery Today ◽  
2015 ◽  
Vol 46 (9) ◽  
pp. 1031-1038 ◽  
Author(s):  
Satoru Ishii ◽  
Keishi Yamashita ◽  
Hiroshi Kato ◽  
Nobuyuki Nishizawa ◽  
Hideki Ushiku ◽  
...  

2021 ◽  
pp. 1-7
Author(s):  
Lili Huang ◽  
Yan Zhou ◽  
Qiuwei Sun ◽  
Lei Cao ◽  
Xueguang Zhang

BACKGROUND and OBJECTIVE: Gastric adenocarcinoma (GAC) is one of the most common malignancies. Increasing data have indicated a correlation between soluble B7-H3 (sB7-H3) levels and tumor malignancies. In this study, we aim to investigate the level of soluble B7-H3 in serum of GAC patients. Further, we analyze the correlation between sB7-H3 level and tissue B7-H3 expression and explore the clinical evaluation value of sB7-H3 associated with pathological characteristics and prognosis of GAC patients. METHODS: One hundred and twenty-eight serum and tissue samples of GAC 20 serum and tissue samples of gastritis patients and 77 serum, 5 tissue samples of healthy controls were collected. The serum levels of sB7-H3 were detected by Enzyme-linked immunosorbent assay (ELISA), while the expression of membrane B7-H3 (mB7-H3) and Ki67 were evaluated by immunohistochemistry. The correlation between sB7-H3 and mB7-H3, sB7-H3 and Ki67, sB7-H3 or mB7-H3 and clinical features were analyzed by Pearson’s Chi-square test. RESULTS: Both serum level of sB7-H3 and tissue B7-H3 of GAC patients were significantly higher than those of gastritis patients and healthy controls. sB7-H3 level was correlated with total B7-H3 expression in tissues (r= 0.2801, P= 0.0014). Notably, the concentration of sB7-H3 was correlated with its expression of membrane form in tumor cells (r= 0.3251, P= 0.002) while not in stromal cells (r= 0.07676, P= 0.3891). Moreover, the levels of sB7-H3 in patients with TNM stage III/IV or with Infiltration depth T3/T4 or with lymph node metastasis were significantly higher than those of patients with TNM stage I/II (P= 0.0020) or with Infiltration depth T1/T2 (P= 0.0169) or with no lymph node metastasis (P= 0.0086). Tumor B7-H3 score, but not stromal B7-H3 score, in patients with TNM stage III/IV or with lymph node metastasis was significantly higher than those with TNM stage I/II (P= 0.0150) or with no lymph node metastasis (P= 0.182). CONCLUSIONS: Soluble B7-H3 level may reflect the tissue B7-H3 expression on tumor cells of GAC tissues. Elevated level of sB7-H3 in serum suggests poor clinical pathological characteristics of GAC patients.


2019 ◽  
Vol 29 (9) ◽  
pp. 1105-1110 ◽  
Author(s):  
Ji Won Kim ◽  
Hyuk Lee ◽  
Yang Won Min ◽  
Byung-Hoon Min ◽  
Jun Haeng Lee ◽  
...  

2012 ◽  
Vol 16 (4) ◽  
pp. 521-530 ◽  
Author(s):  
Mototsugu Fujii ◽  
Yutaro Egashira ◽  
Hiroshi Akutagawa ◽  
Tsukasa Nishida ◽  
Toshikatsu Nitta ◽  
...  

2017 ◽  
Vol 31 (11) ◽  
pp. 4419-4424 ◽  
Author(s):  
Ji Won Park ◽  
Sangjeong Ahn ◽  
Hyuk Lee ◽  
Byung-Hoon Min ◽  
Jun Haeng Lee ◽  
...  

2014 ◽  
Vol 29 (5) ◽  
pp. 1145-1155 ◽  
Author(s):  
Hyo-Joon Yang ◽  
Sang Gyun Kim ◽  
Joo Hyun Lim ◽  
Jeongmin Choi ◽  
Jong Pil Im ◽  
...  

2013 ◽  
Vol 25 ◽  
pp. 21-25 ◽  
Author(s):  
Shiro Oka ◽  
Shinji Tanaka ◽  
Koichi Nakadoi ◽  
Hiroyuki Kanao ◽  
Kazuaki Chayama

2017 ◽  
Vol 152 (5) ◽  
pp. S259-S260
Author(s):  
Dae Won Ma ◽  
Myeong-Cherl Kook ◽  
Do Youn Park ◽  
Sangjeong Ahn ◽  
Keun Won Ryu ◽  
...  

Author(s):  
Leonardo Medeiros Milhomem ◽  
Daniela Medeiros Milhomem-Cardoso ◽  
Orlando Milhomem da Mota ◽  
Eliane Duarte Mota ◽  
Alan Kagan ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document