scholarly journals Quality Assurance in Modern Gynecological HDR-Brachytherapy (Interventional Radiotherapy): Clinical Considerations and Comments

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 912
Author(s):  
Tamer Soror ◽  
Frank-André Siebert ◽  
Valentina Lancellotta ◽  
Elisa Placidi ◽  
Bruno Fionda ◽  
...  

The use of brachytherapy (interventional radiotherapy) in the treatment of gynecological cancers is a crucial element in both definitive and adjuvant settings. The recent developments in high-dose rate remote afterloaders, modern applicators, treatment-planning software, image guidance, and dose monitoring systems have led to improvement in the local control rates and in some cases improved the survival rates. The development of these highly advanced and complicated treatment modalities has been accompanied by challenges, which have made the existence of quality assurance protocols a must to ensure the integrity of the treatment process. Quality assurance aims at standardizing the technical and clinical procedures involved in the treatment of patients, which could eventually decrease the source of uncertainties whether technical (source/equipment related) or clinical. This commentary review sheds light (from a clinical point of view) on some potential sources of uncertainties associated with the use of modern brachytherapy in the treatment of gynecological cancers.

Cancers ◽  
2021 ◽  
Vol 13 (19) ◽  
pp. 4942
Author(s):  
Maria Grazia Ronga ◽  
Marco Cavallone ◽  
Annalisa Patriarca ◽  
Amelia Maia Leite ◽  
Pierre Loap ◽  
...  

The development of innovative approaches that would reduce the sensitivity of healthy tissues to irradiation while maintaining the efficacy of the treatment on the tumor is of crucial importance for the progress of the efficacy of radiotherapy. Recent methodological developments and innovations, such as scanned beams, ultra-high dose rates, and very high-energy electrons, which may be simultaneously available on new accelerators, would allow for possible radiobiological advantages of very short pulses of ultra-high dose rate (FLASH) therapy for radiation therapy to be considered. In particular, very high-energy electron (VHEE) radiotherapy, in the energy range of 100 to 250 MeV, first proposed in the 2000s, would be particularly interesting both from a ballistic and biological point of view for the establishment of this new type of irradiation technique. In this review, we examine and summarize the current knowledge on VHEE radiotherapy and provide a synthesis of the studies that have been published on various experimental and simulation works. We will also consider the potential for VHEE therapy to be translated into clinical contexts.


2015 ◽  
Vol 115 ◽  
pp. S139-S140
Author(s):  
A. Espinoza ◽  
M. Petasecca ◽  
I. Fuduli ◽  
A. Howie ◽  
S. Corde ◽  
...  

2004 ◽  
Vol 59 (4) ◽  
pp. 1224-1228 ◽  
Author(s):  
Rupak K. Das ◽  
Rakesh Patel ◽  
Hiral Shah ◽  
Heath Odau ◽  
Robert R. Kuske

2014 ◽  
Vol 21 (13) ◽  
pp. 4284-4292 ◽  
Author(s):  
Georg Brinkhaus ◽  
Johan Friso Lock ◽  
Maciej Malinowski ◽  
Timm Denecke ◽  
Peter Neuhaus ◽  
...  

2010 ◽  
Vol 37 (7Part3) ◽  
pp. 3910-3910
Author(s):  
D Rickey ◽  
D Sasaki ◽  
J Bews

Brachytherapy ◽  
2006 ◽  
Vol 5 (2) ◽  
pp. 96
Author(s):  
Murali Nair ◽  
Rufus Mark ◽  
Paul Anderson ◽  
Thomas Neumann ◽  
David White ◽  
...  

2010 ◽  
Vol 37 (6Part1) ◽  
pp. 2525-2532 ◽  
Author(s):  
Daniel W. Rickey ◽  
David Sasaki ◽  
Jeff Bews

Brachytherapy ◽  
2016 ◽  
Vol 15 (2) ◽  
pp. 252-262 ◽  
Author(s):  
Vasiliki Peppa ◽  
Evaggelos Pantelis ◽  
Eleftherios Pappas ◽  
Vasileios Lahanas ◽  
Constantinos Loukas ◽  
...  

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