scholarly journals Shorter Leukocyte Telomere Length Is Associated with Worse Survival of Patients with Bladder Cancer and Renal Cell Carcinoma

Cancers ◽  
2021 ◽  
Vol 13 (15) ◽  
pp. 3774
Author(s):  
Xi Zheng ◽  
Felix Wezel ◽  
Anca Azoitei ◽  
Sabine Meessen ◽  
Wenya Wang ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Bladder Cancer ◽  
Cell Carcinoma ◽  
Telomere Length ◽  
Renal Cell ◽  
Malignant Disease ◽  
Independent Predictor ◽  
Normal Population ◽  
Peripheral Blood Leukocyte ◽  
Telomeric Dna

Background: Telomeres are protein–DNA complexes at the tips of linear chromosomes. They protect the DNA from end-to-end fusion and exonucleolytic degradation. Shortening of telomeric DNA during aging can generate dysfunctional telomeres, promoting tumorigenesis. More recent data indicate that both short and long telomeres of peripheral blood leukocyte (PBL) cells can serve as prognostic biomarkers for cancer risk and may be associated with survival of patients with solid cancers. Telomere length in PBL cells could also be a potential prognostic biomarker for survival in bladder cancer (BC) or renal cell carcinoma (RCC). Methods: The relative telomere length (RTL) of PBL cells was assessed in patients with BC (n = 144) and RCC (n = 144) by using qPCR. A control population of patients without malignant disease (NC, n = 73) was included for comparison. The correlation and association of RTL with histopathological parameters and overall survival (OS) were evaluated. Results: Patients with BC and RCC had significantly shorter telomeres compared to patients without malignant disease. Within the cancer cohorts, multivariate analysis revealed that short RTL is an independent predictor of worse survival in BC (p = 0.039) and RCC (p = 0.041). Conclusion: Patients with BC and RCC had significantly shorter telomeres compared to the normal population. Shorter RTL in BC and RCC was an independent predictor of reduced survival.

scholarly journals A Unique Urinary Metabolic Feature for the Determination of Bladder Cancer, Prostate Cancer, and Renal Cell Carcinoma

Metabolites ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 591
Author(s):  
Sujin Lee ◽  
Ja Yoon Ku ◽  
Byeong Jin Kang ◽  
Kyung Hwan Kim ◽  
Hong Koo Ha ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Renal Cell Carcinoma ◽  
Bladder Cancer ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Clinical Signs ◽  
Analysis Of Covariance ◽  
Characteristic Analysis ◽  
Discriminatory Accuracy ◽  
Urological Cancers

Prostate cancer (PCa), bladder cancer (BCa), and renal cell carcinoma (RCC) are the most prevalent cancer among urological cancers. However, there are no cancer-specific symptoms that can differentiate them as well as early clinical signs of urological malignancy. Furthermore, many metabolic studies have been conducted to discover their biomarkers, but the metabolic profiling study to discriminate between these cancers have not yet been described. Therefore, in this study, we aimed to investigate the urinary metabolic differences in male patients with PCa (n = 24), BCa (n = 29), and RCC (n = 12) to find the prominent combination of metabolites between cancers. Based on 1H NMR analysis, orthogonal partial least-squares discriminant analysis was applied to find distinct metabolites among cancers. Moreover, the ranked analysis of covariance by adjusting a potential confounding as age revealed that 4-hydroxybenzoate, N-methylhydantoin, creatinine, glutamine, and acetate had significantly different metabolite levels among groups. The receiver operating characteristic analysis created by prominent five metabolites showed the great discriminatory accuracy with AUC > 0.7 for BCa vs. RCC, PCa vs. BCa, and RCC vs. PCa. This preliminary study compares the metabolic profiles of BCa, PCa, and RCC, and reinforces the exploratory role of metabolomics in the investigation of human urine.

Age at Diagnosis is an Independent Predictor of Small Renal Cell Carcinoma Recurrence-Free Survival

2009 ◽  
Vol 182 (2) ◽  
pp. 445-450 ◽  
Author(s):  
In Gab Jeong ◽  
Chang Hee Yoo ◽  
Kanghyon Song ◽  
Jinsung Park ◽  
Yong Mee Cho ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Independent Predictor ◽  
Age At Diagnosis ◽  
Recurrence Free Survival ◽  
Free Survival

scholarly journals Telomere Length in Relation to Immunological Parameters in Patients with Renal Cell Carcinoma

PLoS ONE ◽  
2013 ◽  
Vol 8 (2) ◽  
pp. e55543 ◽  
Author(s):  
Ulrika Svenson ◽  
Elisabeth Grönlund ◽  
Ingegerd Söderström ◽  
Raviprakash T. Sitaram ◽  
Börje Ljungberg ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Telomere Length ◽  
Renal Cell ◽  
Immunological Parameters
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