Asymmetric Ring-Opening of Epoxides Catalyzed by Metal–Salen Complexes
Keyword(s):
One Step
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The asymmetric ring-opening of epoxides is an important reaction in organic synthesis, since it allows for the enantioselective installation of two vicinal functional groups with specific stereochemistry within one step from a highly available starting material. An effective class of catalysts for the asymmetric ring-opening of epoxides is metal–salen complexes. This review summarizes the development of metal–salen catalyzed enantioselective desymmetrization of meso-epoxides and kinetic resolution of epoxides with various nucleophiles, including the design and application of both homogeneous- and heterogeneous epoxide-opening catalysts as well as multi-metallic covalent and supramolecular catalytic systems.
2007 ◽
Vol 124-126
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pp. 1809-1812
2014 ◽
Vol 25
(10-11)
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pp. 838-843
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2005 ◽
Vol 235
(2)
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pp. 428-430
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