scholarly journals Novel Bifunctional Mesoporous Catalysts Based on Preyssler Heteropolyacids for Green Pyrrole Derivative Synthesis

Catalysts ◽  
2018 ◽  
Vol 8 (10) ◽  
pp. 419 ◽  
Author(s):  
Omar Portilla-Zúñiga ◽  
Ángel Sathicq ◽  
José Martínez ◽  
Hugo Rojas ◽  
Eduardo De Geronimo ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Mesoporous Alumina ◽  
Solvent Free ◽  
Acid Base ◽  
One Pot ◽  
Pyrrole Derivatives ◽  
Mesoporous Catalysts ◽  
Pyrrole Derivative ◽  
Solvent Free Conditions ◽  
Subsequent Conversion

In this paper, we report the synthesis of Preyssler heteropolyacids supported on mesoporous alumina in order to obtain materials with acid–base properties. A series of pyrrole derivatives were synthesized using a suitable procedure under solvent-free conditions. Using the alumina-supported material, more complex pyrrole derivatives can be obtained through a tandem one-pot process that involves the formation of 2-amino-3-cyano 4-H-chromenes by a multicomponent reaction and their subsequent conversion to pyrrole using a Paal–Knorr reaction.

scholarly journals Assembly of fully substituted triazolochromenes via a novel multicomponent reaction or mechanochemical synthesis

2018 ◽  
Vol 14 ◽  
pp. 2689-2697 ◽  
Author(s):  
Robby Vroemans ◽  
Yenthel Verhaegen ◽  
My Tran Thi Dieu ◽  
Wim Dehaen
Keyword(s):  
Multicomponent Reaction ◽  
Mechanochemical Synthesis ◽  
Solvent Free ◽  
Viable Alternative ◽  
Dipolar Cycloaddition ◽  
One Pot ◽  
Biologically Relevant ◽  
Metal Free ◽  
Organic Azides ◽  
Solvent Free Conditions

A new metal-free one-pot three-component procedure towards fully substituted triazolochromenes has been developed, starting from commercially available materials. Salicylaldehydes and nitroalkenes were reacted under solvent-free conditions, followed by a 1,3-dipolar cycloaddition of the intermediate 3-nitro-2H-chromenes with organic azides in a one-pot two-step sequence. The triazolochromenes were formed with complete regioselectivity and new biologically relevant structures were synthesized via extension of the developed procedure and via postfunctionalization. The mechanochemical synthesis was carried out for several salicylaldehydes and gave a clear improvement in the yield of the corresponding triazolochromenes and consequently showed to be a viable alternative for solid salicylaldehydes.

Facile one-pot three-component synthesis of diverse 2,3-disubstituted isoindolin-1-ones using ZrO2 nanoparticles as a reusable dual acid–base solid support under solvent-free conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (25) ◽  
pp. 21127-21138 ◽  
Author(s):  
Kamalesh Debnath ◽  
Sayan Mukherjee ◽  
Chandan Bodhak ◽  
Animesh Pramanik
Keyword(s):  
Solid Support ◽  
Solvent Free ◽  
Zro2 Nanoparticles ◽  
Acid Base ◽  
One Pot ◽  
Solvent Free Conditions

A series of multi-functionalized 2,3-disubstituted isoindolin-1-ones has been synthesized using ZrO2 nanoparticles as a dual acid–base solid support under solvent-free conditions.

Nano zirconia catalysed one-pot synthesis of some novel substituted imidazoles under solvent-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (36) ◽  
pp. 28163-28170 ◽  
Author(s):  
Shivam Bajpai ◽  
Sundaram Singh ◽  
Vandana Srivastava
Keyword(s):  
Multicomponent Reaction ◽  
Efficient Method ◽  
Ammonium Acetate ◽  
Aromatic Aldehydes ◽  
Solvent Free ◽  
One Pot ◽  
Highly Efficient ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Isatin Derivatives

A highly efficient method for the synthesis of substituted imidazoles from a multicomponent reaction of isatin derivatives with ammonium acetate and aromatic aldehydes under solvent-free conditions has been established.

Zn(OAc)2•2H2O-Catalyzed Betti Base Synthesis under Solvent-free Conditions

2021 ◽  
Vol 18 ◽  
Author(s):  
M. Mujahid Alam ◽  
B. Hari Babu ◽  
Ravi Varala
Keyword(s):  
Multicomponent Reaction ◽  
Solvent Free ◽  
One Pot ◽  
Betti Base ◽  
Solvent Free Conditions ◽  
High Yields ◽  
Work Up ◽  
Operational Simplicity

: Zn(OAc)2•2H2O-catalyzed one-pot multicomponent reaction of Betti bases using β-napthol, aldehydes, and amines, under neat conditions in moderate to excellent yields (68-96%) is reported. This synthetic protocol offers several advantages, such as operational simplicity, shorter reaction period, high yields, and easy work-up procedures.

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