scholarly journals The Function of Immunoproteasomes—An Immunologists’ Perspective

Cells ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 3360
Author(s):  
Bart L. van den Eshof ◽  
Lobna Medfai ◽  
Emanuele Nolfi ◽  
Magdalena Wawrzyniuk ◽  
Alice J. A. M. Sijts

Proteasomes are responsible for intracellular proteolysis and play an important role in cellular protein homeostasis. Cells of the immune system assemble a specialized form of proteasomes, known as immunoproteasomes, in which the constitutive catalytic sites are replaced for cytokine-inducible homologues. While immunoproteasomes may fulfill all standard proteasome’ functions, they seem specially adapted for a role in MHC class I antigen processing and CD8+ T-cell activation. In this way, they may contribute to CD8+ T-cell-mediated control of intracellular infections, but also to the immunopathogenesis of autoimmune diseases. Starting at the discovery of its catalytic subunits in the genome, here, we review the observations shaping our current understanding of immunoproteasome function, and the consequential novel opportunities for immune intervention.

2022 ◽  
Author(s):  
Tresa Rani Sarraf ◽  
Malini Sen

Antigen processing, cross-presentation, and antigen-specific CD8 T cell response form part and parcel of T cell-mediated immunity. Yet, lacunae remain in our understanding of antigen processing/presentation and CD8 T cell response. Given the association of Wnt5A signaling with immune homeostasis, we evaluated the utility of Wnt5A in antigen processing, cross-presentation, and CD8 T cell activation. Using mouse bone marrow-derived dendritic cells as antigen-presenting cells and ovalbumin as a model antigen we found that Wnt5A mediated regulation of actin and proteasome dynamics is inherently associated with antigen processing. A Wnt5A-Actin-Protasome axis also contributes to antigen cross-presentation and antigen responsive CD8 T cell expansion. In concurrence with these observations, we demonstrated impaired activation of ovalbumin-specific CD8 T cells in ovalbumin immunized Wnt5A heterozygous mice as illustrated by their poor CD8 T cell recall response to ovalbumin when compared to similarly immunized wild type cohorts. Our results suggest that Wnt5A signaling-directed antigen processing/presentation could be vital for generating CD8 T cell recall response to antigen, thus shedding light on a critical parameter of immunity.


Immunity ◽  
2013 ◽  
Vol 38 (1) ◽  
pp. 153-165 ◽  
Author(s):  
Sun-Young Chang ◽  
Joo-Hye Song ◽  
Bayasi Guleng ◽  
Carmen Alonso Cotoner ◽  
Seiji Arihiro ◽  
...  

MicroRNA ◽  
2015 ◽  
Vol 4 (2) ◽  
pp. 117-122 ◽  
Author(s):  
Nato Teteloshvili ◽  
Katarzyna Smigielska-Czepiel ◽  
Bart-Jan Kroesen ◽  
Elisabeth Brouwer ◽  
Joost Kluiver ◽  
...  

2021 ◽  
Vol 147 (2) ◽  
pp. AB151
Author(s):  
Jose Campos ◽  
Peyton Conrey ◽  
Samir Sayed ◽  
Tiphanie Vogel ◽  
Jennifer Leiding ◽  
...  

1995 ◽  
Vol 40 (6) ◽  
pp. 390-396 ◽  
Author(s):  
Gijsbert C. de Gast ◽  
Inez-Anne Haagen ◽  
Anja A. van Houten ◽  
Sigrid C. Klein ◽  
Ashley J. Duits ◽  
...  

2012 ◽  
Vol 35 (2) ◽  
pp. 142-153 ◽  
Author(s):  
Maarten L. Zandvliet ◽  
Michel G. D. Kester ◽  
Ellis van Liempt ◽  
Arnoud H. de Ru ◽  
Peter A. van Veelen ◽  
...  

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