Interaction Information Along Lifespan of the Resting Brain Dynamics Reveals a Major Redundant Role of the Default Mode Network

AbstractInteraction Information generalizes the univariate Shannon Entropy to triplets of variables, allowing the detection of redundant or synergetic interactions in dynamical networks. Here, we calculated interaction information from functional magnetic resonance imaging and asked whether redundancy or synergy vary across brain regions and along lifespan. We found high overlapping between the pattern of high redundancy and the default mode network, and this occurred along lifespan. The pattern of high values of synergy, more heterogeneous and variable along lifespan, was overlapping with different cognitive domains, such as spatial and temporal memory, emotion processing and motor skills. Moreover, the amount of redundancy and synergy seem to be balanced along lifespan, suggesting informational compensatory mechanisms in brain networks.

Download Full-text

Task-positive Functional Connectivity of the Default Mode Network Transcends Task Domain

Journal of Cognitive Neuroscience ◽

10.1162/jocn_a_00859 ◽

2015 ◽

Vol 27 (12) ◽

pp. 2369-2381 ◽

Cited By ~ 43

Author(s):

Amanda Elton ◽

Wei Gao

Keyword(s):

Functional Connectivity ◽

Task Performance ◽

Default Mode Network ◽

Inferior Frontal Gyrus ◽

Brain Regions ◽

Positive Functional ◽

Default Mode ◽

Goal Directed Behavior ◽

Increased Activity

The default mode network (DMN) was first recognized as a set of brain regions demonstrating consistently greater activity during rest than during a multitude of tasks. Originally, this network was believed to interfere with goal-directed behavior based on its decreased activity during many such tasks. More recently, however, the role of the DMN during goal-directed behavior was established for internally oriented tasks, in which the DMN demonstrated increased activity. However, the well-documented hub position and information-bridging potential of midline DMN regions indicate that there is more to uncover regarding its functional contributions to goal-directed tasks, which may be based on its functional interactions rather than its level of activation. An investigation of task-related changes in DMN functional connectivity during a series of both internal and external tasks would provide the requisite investigation for examining the role of the DMN during goal-directed task performance. In this study, 20 participants underwent fMRI while performing six tasks spanning diverse internal and external domains in addition to a resting-state scan. We hypothesized that the DMN would demonstrate “task-positive” (i.e., positively contributing to task performance) changes in functional connectivity relative to rest regardless of the direction of task-related changes in activity. Indeed, our results demonstrate significant increases in DMN connectivity with task-promoting regions (e.g., anterior insula, inferior frontal gyrus, middle frontal gyrus) across all six tasks. Furthermore, canonical correlation analyses indicated that the observed task-related connectivity changes were significantly associated with individual differences in task performance. Our results indicate that the DMN may not only support a “default” mode but may play a greater role in both internal and external tasks through flexible coupling with task-relevant brain regions.

Download Full-text

Modulatory interactions between the default mode network and task positive networks in resting-state

10.7287/peerj.preprints.124v2 ◽

2014 ◽

Author(s):

Xin Di ◽

Bharat B. Biswal

Keyword(s):

Basal Ganglia ◽

Default Mode Network ◽

Resting State ◽

Brain Structures ◽

Brain Regions ◽

Salience Network ◽

Imaging Data ◽

Default Mode ◽

Task Positive Network ◽

And Task

The two major brain networks, i.e. the default mode network (DMN) and the task positive network, typically reveal negative and variable connectivity in resting-state. In the present study, we examined whether the connectivity between the DMN and different components of the task positive network were modulated by other brain regions by using physiophysiological interaction (PPI) on resting-state functional magnetic resonance imaging data. Spatial independent component analysis was first conducted to identify components that represented networks of interest, including the anterior and posterior DMNs, salience, dorsal attention, left and right executive networks. PPI analysis was conducted between pairs of these networks to identify networks or regions that showed modulatory interactions with the two networks. Both network-wise and voxel-wise analyses revealed reciprocal positive modulatory interactions between the DMN, salience, and executive networks. Together with the anatomical properties of the salience network regions, the results suggest that the salience network may modulate the relationship between the DMN and executive networks. In addition, voxel-wise analysis demonstrated that the basal ganglia and thalamus positively interacted with the salience network and the dorsal attention network, and negatively interacted with the salience network and the DMN. The results demonstrated complex modulatory interactions among the DMNs and task positive networks in resting-state, and suggested that communications between these networks may be modulated by some critical brain structures such as the salience network, basal ganglia, and thalamus.

Download Full-text

Modulatory interactions between the default mode network and task positive networks in resting-state

10.7287/peerj.preprints.124 ◽

2014 ◽

Cited By ~ 1

Author(s):

Xin Di ◽

Bharat B. Biswal

Keyword(s):

Basal Ganglia ◽

Default Mode Network ◽

Resting State ◽

Brain Structures ◽

Brain Regions ◽

Salience Network ◽

Imaging Data ◽

Default Mode ◽

Task Positive Network ◽

And Task

The two major brain networks, i.e. the default mode network (DMN) and the task positive network, typically reveal negative and variable connectivity in resting-state. In the present study, we examined whether the connectivity between the DMN and different components of the task positive network were modulated by other brain regions by using physiophysiological interaction (PPI) on resting-state functional magnetic resonance imaging data. Spatial independent component analysis was first conducted to identify components that represented networks of interest, including the anterior and posterior DMNs, salience, dorsal attention, left and right executive networks. PPI analysis was conducted between pairs of these networks to identify networks or regions that showed modulatory interactions with the two networks. Both network-wise and voxel-wise analyses revealed reciprocal positive modulatory interactions between the DMN, salience, and executive networks. Together with the anatomical properties of the salience network regions, the results suggest that the salience network may modulate the relationship between the DMN and executive networks. In addition, voxel-wise analysis demonstrated that the basal ganglia and thalamus positively interacted with the salience network and the dorsal attention network, and negatively interacted with the salience network and the DMN. The results demonstrated complex modulatory interactions among the DMNs and task positive networks in resting-state, and suggested that communications between these networks may be modulated by some critical brain structures such as the salience network, basal ganglia, and thalamus.

Download Full-text

The Surprising Role of the Default Mode Network

10.1101/2020.05.18.101758 ◽

2020 ◽

Author(s):

T. Brandman ◽

R. Malach ◽

E. Simony.

Keyword(s):

Default Mode Network ◽

Prediction Error ◽

Pattern Analysis ◽

Brain Regions ◽

Default Mode ◽

Cognitive States ◽

Fluctuation Pattern ◽

Unexpected Findings ◽

High Level

AbstractThe default mode network (DMN) is a group of high-order brain regions recently implicated in processing external naturalistic events, yet it remains unclear what cognitive function it serves. Here we identified the cognitive states predictive of DMN fMRI coactivation. Particularly, we developed a state-fluctuation pattern analysis, matching network coactivations across a short movie with retrospective behavioral sampling of movie events. Network coactivation was selectively correlated with the state of surprise across movie events, compared to all other cognitive states (e.g. emotion, vividness). The effect was exhibited in the DMN, but not dorsal attention or visual networks. Furthermore, surprise was found to mediate DMN coactivations with hippocampus and nucleus accumbens. These unexpected findings point to the DMN as a major hub in high-level prediction-error representations.

Download Full-text

Modulatory Interactions between the Default Mode Network and Task Positive Networks in Resting-State

10.7287/peerj.preprints.124v1 ◽

2013 ◽

Author(s):

Xin Di ◽

Bharat B. Biswal

Keyword(s):

Basal Ganglia ◽

Functional Connectivity ◽

Default Mode Network ◽

Resting State ◽

Brain Networks ◽

Brain Regions ◽

Salience Network ◽

Imaging Data ◽

Default Mode ◽

Brain Functions

Communications between different brain systems are critical to support complex brain functions. Unlike generally high functional connectivity between brain regions from same system, functional connectivity between regions from different systems are more variable. In the present study, we examined whether the connectivity between different brain networks were modulated by other regions by using physiophysiological interaction (PPI) on resting-state functional magnetic resonance imaging data. Spatial independent component analysis was first conducted to identify the default mode network (DMN) and several task positive networks, including the salience, dorsal attention, left and right executive networks. PPI analysis was conducted between pairs of these networks to identify networks or regions that showed modulatory interactions with the two networks. Network-wise analysis revealed reciprocal modulatory interactions between the DMN, salience, and executive networks. Together with the anatomical properties of the salience network regions, the results suggest that the salience network may modulate the relationship between the DMN and executive networks. In addition, voxel-wise analysis demonstrated that the basal ganglia and thalamus positively interacted with the salience network and the dorsal attention network, and negatively interacted with the salience network and the DMN. The results demonstrated complex relationships among brain networks in resting-state, and suggested that between network communications of these networks may be modulated by some critical brain structures such as the salience network, basal ganglia, and thalamus.

Download Full-text

The surprising role of the default mode network in naturalistic perception

Communications Biology ◽

10.1038/s42003-020-01602-z ◽

2021 ◽

Vol 4 (1) ◽

Author(s):

Talia Brandman ◽

Rafael Malach ◽

Erez Simony

Keyword(s):

Default Mode Network ◽

Prediction Error ◽

Pattern Analysis ◽

Brain Regions ◽

Default Mode ◽

Cognitive States ◽

Fluctuation Pattern ◽

Unexpected Findings ◽

High Level

AbstractThe default mode network (DMN) is a group of high-order brain regions recently implicated in processing external naturalistic events, yet it remains unclear what cognitive function it serves. Here we identified the cognitive states predictive of DMN fMRI coactivation. Particularly, we developed a state-fluctuation pattern analysis, matching network coactivations across a short movie with retrospective behavioral sampling of movie events. Network coactivation was selectively correlated with the state of surprise across movie events, compared to all other cognitive states (e.g. emotion, vividness). The effect was exhibited in the DMN, but not dorsal attention or visual networks. Furthermore, surprise was found to mediate DMN coactivations with hippocampus and nucleus accumbens. These unexpected findings point to the DMN as a major hub in high-level prediction-error representations.

Download Full-text