scholarly journals Antistaphylococcal activity of polychlorinated <em>N</em>-arylcinnamamides

2020 ◽  
Author(s):  
Hana Michnová ◽  
Tomas Strharsky ◽  
Jiri Kos ◽  
Alois Čížek ◽  
Josef Jampílek
Keyword(s):  
Antistaphylococcal Activity

Antistaphylococcal activity of carbonic acid extract of hops

2018 ◽  
Vol 22 (2) ◽  
pp. 297-300
Author(s):  
V.V. Nevmerzhitsky ◽  
V.Yu. Ivannik ◽  
V.V. Kazmirchuk ◽  
T.N. Moiseenko ◽  
T.A. Volkov ◽  
...  
Keyword(s):  
Carbon Dioxide ◽  
Antimicrobial Agents ◽  
Carbonic Acid ◽  
Inflammatory Diseases ◽  
Acquired Resistance ◽  
Biologically Active ◽  
Antibacterial Drugs ◽  
Antistaphylococcal Activity ◽  
Prevention And Treatment ◽  
Main Disadvantage

The fight against staphylococcal infection, increasing the effectiveness of methods of prevention and treatment of diseases of staphylococcal etiology is of interest to scientists and practitioners, both in Ukraine and around the world. The urgency of this problem is growing rapidly, as there is a tendency to increase the resistance of not only staphylococci, but also other gram-positive bacteria. The spread of methicillin-resistant staphylococci restricts the choice of antibiotics for the treatment of diseases of staphylococcal etiology. Staphylococcus aureus is the most common and dangerous type, which is one of the main factors of purulent-inflammatory lesions of the skin and mucous membranes. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. As a result of mutations, pathogenic staphylococci acquired resistance to antibacterial drugs. The main disadvantage of modern antibiotics is their non-selectivity. One of the unique and promising medicinal plants, which contains a rich complex of biologically active substances (BAS), is common hops (Humulus lupulus L.). The complex of BAS (flavonoids, hormones, vitamins, bitter, phenolic compounds, essential oils) causes anti-inflammatory, bactericidal, hyposensitizing and analgesic action of hops. The purpose of this work is to determine the antistaphylococcal activity of the carbon dioxide extract of hops and to justify the development on its basis of new antimicrobial agents for the prevention and treatment of infectious and purulent-inflammatory diseases. The following methods were used: microbiological (method of diffusion into agar (well method)) and mathematical and statistical. The high antimicrobial activity of the carbon dioxide extract of hops has been established for museum test strains of the genus Staphylococcus. The results of the studies testify to the prospects of further study of the bactericidal properties of the extract of hops carbon dioxide with the aim of creating effective antimicrobial agents on its basis for the prevention and treatment of infectious and purulent-inflammatory diseases of staphylococcal etiology.

Pharmacokinetics and Pharmacodynamics of Antistaphylococcal Antibiotics in Continuous Ambulatory Peritoneal Dialysis Patients

1993 ◽  
Vol 13 (2_suppl) ◽  
pp. 367-371 ◽  
Author(s):  
Erich Keller
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Inhibitory Concentration ◽  
Pharmacokinetic Data ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Antistaphylococcal Activity ◽  
Cure Rates ◽  
Vitro Data ◽  
In Vitro Data

Staphylococci are the leading pathogens In continuous ambulatory peritoneal dialysis (CAPD)-related peritonitis. Vancomycin appears to be an outstanding antistaphylococcal drug because resistance to It Is nearly absent. The pharmacokinetics of vancomycin and clinical cure rates of peritonitis with different dosing guidelines have been studied extensively. Different dosing guidelines with IP or IV loading doses followed or not followed by IP maintenance doses are used successfully, despite the fact that some of the dosing schemes produce apparently suboptimal drug levels referring to In vitro data like the MIC value (minimum Inhibitory concentration). Alternatively, amlnoglycosldes, cephalosporlns, Isoxazolyl penicillins, and broad-spectrum penicillins combined with betalactamase Inhibitors may be used for the treatment of gram-positive peritonitis. For the above panicillins pharmacokinetic data are scarce, and clinical experience is limited. Rifampin has excellent Intracellular antistaphylococcal activity and should be used In combination with other antibiotics. Although pharmacokinetic data are lacking, rifampin dosages do not require adaptation to renal function or replacement therapy.

scholarly journals Synergistic Interaction of Methanol Extract fromCanarium odontophyllumMiq. Leaf in Combination with Oxacillin against Methicillin-ResistantStaphylococcus aureus(MRSA) ATCC 33591

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Dayang Fredalina Basri ◽  
Vimashiinee Sandra
Keyword(s):  
Inhibitory Concentration ◽  
Methanol Extract ◽  
Bactericidal Effect ◽  
Acetone Extract ◽  
Pharmacodynamic Interaction ◽  
Antistaphylococcal Activity ◽  
Preliminary Study ◽  
Canarium Odontophyllum ◽  
Time Kill ◽  
Acetone Extracts

Canarium odontophyllum(CO) Miq. has been considered as one of the most sought-after plant species in Sarawak, Malaysia, due to its nutritional and pharmacological benefits. This study aimed to evaluate the pharmacodynamic interaction of crude methanol and acetone extracts from CO leaves in combination with oxacillin, vancomycin, and linezolid, respectively, against MRSA ATCC 33591 as preliminary study has reported its potential antistaphylococcal activity. The broth microdilution assay revealed that both methanol and acetone extracts were bactericidal with Minimum Inhibitory Concentration (MIC) of 312.5 μg/mL and 156.25 μg/mL and Minimum Bactericidal Concentration (MBC) of 625 μg/mL and 312.5 μg/mL, respectively. Fractional Inhibitory Concentration (FIC) indices were obtained via the chequerboard dilution assay where methanol extract-oxacillin, acetone extract-oxacillin, methanol extract-linezolid, and acetone extract-linezolid combinations exhibited synergism (FIC index ≤ 0.5). The synergistic action of the methanol extract-oxacillin combination was verified by time-kill analysis where bactericidal effect was observed at concentration of 1/8 × MIC of both compounds at 9.6 h compared to oxacillin alone. As such, these findings postulated that both extracts exert their anti-MRSA mechanism of action similar to that of vancomycin and provide evidence that the leaves ofC. odontophyllumhave the potential to be developed into antistaphylococcal agents.

ANTISTAPHYLOCOCCAL ACTIVITY OF FUCIDIN

The Lancet ◽  
1962 ◽  
Vol 279 (7236) ◽  
pp. 935-937 ◽  
Author(s):  
G. Taylor ◽  
K. Bloor
Keyword(s):  
Antistaphylococcal Activity

Antistaphylococcal Activity of Xanthium cavanillesii Lactones

2014 ◽  
Vol 6 (6) ◽  
pp. 39-42
Author(s):  
Cristina Olivaro ◽  
Nicole Paris ◽  
Cerdeiras M. Pía ◽  
Alvaro Vázquez
Keyword(s):  
Antistaphylococcal Activity

scholarly journals Antistaphylococcal activity of new salicylamide analogues

2019 ◽  
Author(s):  
Hana Michnová ◽  
Ales Imramovsky ◽  
Pratibha Magar ◽  
Alois Čížek ◽  
Josef Jampílek
Keyword(s):  
Antistaphylococcal Activity

In vitro Antistaphylococcal Activity of the Extracts of Several Neglected Plants in Malaysia

2007 ◽  
Vol 3 (5) ◽  
pp. 428-431 ◽  
Author(s):  
Z.A. Zakaria ◽  
A.M. Mat Jais ◽  
M. Mastura ◽  
S.H. Mat Jusoh ◽  
A.M. Mohamed ◽  
...  
Keyword(s):  
Antistaphylococcal Activity

scholarly journals Synthesis of New Oxindoles and Determination of Their Antibacterial Properties

2020 ◽  
Vol 2020 ◽  
pp. 1-9
Author(s):  
Pablo E. Romo ◽  
Braulio Insuasty ◽  
Rodrigo Abonia ◽  
María del Pilar Crespo ◽  
Jairo Quiroga
Keyword(s):  
Staphylococcus Aureus ◽  
Antibacterial Activity ◽  
Neisseria Gonorrhoeae ◽  
Room Temperature ◽  
Antibacterial Properties ◽  
Analytical Techniques ◽  
Toluenesulfonic Acid ◽  
Antistaphylococcal Activity ◽  
New Compounds

A versatile method for the synthesis of new oxindoles was developed by the reaction between substituted isatins and 5-aminopyrazoles. The reaction was carried out at room temperature in ethanol using p-toluenesulfonic acid as the catalyst. The products were obtained with acceptable to excellent yields (44–96%). Structures of the new compounds were unambiguously established by spectroscopic and analytical techniques. The antibacterial activity was determined by microdilution assays. Compounds 3b, 3e, and 3g showed antistaphylococcal activity, particularly compound 3e displayed a potent activity against the vancomycin intermediate Staphylococcus aureus (VISA). Compounds 3i, 3j, and 3o inhibited Neisseria gonorrhoeae growth.

scholarly journals Antistaphylococcal Activity of LBM415, a New Peptide Deformylase Inhibitor, Compared with Those of Other Agents

2004 ◽  
Vol 48 (10) ◽  
pp. 4033-4036 ◽  
Author(s):  
Kim Credito ◽  
Gengrong Lin ◽  
Lois M. Ednie ◽  
Peter C. Appelbaum
Keyword(s):  
Staphylococcus Aureus ◽  
Peptide Deformylase ◽  
Coagulase Negative Staphylococci ◽  
Antistaphylococcal Activity

ABSTRACT The MICs of LBM415, a new peptide diformylase inhibitor, were ≤0.06 to 4.0 μg/ml for 258 isolates of Staphylococcus aureus and coagulase-negative staphylococci. LBM415 MICs were similar irrespective of whether the strains were methicillin susceptible or resistant. All strains were also susceptible to vancomycin, linezolid, ranbezolid, daptomycin, oritavancin, and quinupristin-dalfopristin. LBM415 at the MIC was bacteriostatic after 24 h.

Sign in / Sign up

Export Citation Format

Share Document