scholarly journals RNA Editors, Cofactors, and mRNA Targets: An Overview of the C-to-U RNA Editing Machinery and Its Implication in Human Disease

Genes ◽  
2018 ◽  
Vol 10 (1) ◽  
pp. 13 ◽  
Author(s):  
Taga Lerner ◽  
F. Papavasiliou ◽  
Riccardo Pecori
Keyword(s):  
Rna Editing ◽  
Human Disease ◽  
Mrna Targets ◽  
Higher Eukaryotes ◽  
Apobec Family ◽  
Emergent Knowledge

One of the most prevalent epitranscriptomic modifications is RNA editing. In higher eukaryotes, RNA editing is catalyzed by one of two classes of deaminases: ADAR family enzymes that catalyze A-to-I (read as G) editing, and AID/APOBEC family enzymes that catalyze C-to-U. ADAR-catalyzed deamination has been studied extensively. Here we focus on AID/APOBEC-catalyzed editing, and review the emergent knowledge regarding C-to-U editing consequences in the context of human disease.

ADAR RNA editing in human disease; more to it than meets the I

2017 ◽  
Vol 136 (9) ◽  
pp. 1265-1278 ◽  
Author(s):  
Angela Gallo ◽  
Dragana Vukic ◽  
David Michalík ◽  
Mary A. O’Connell ◽  
Liam P. Keegan
Keyword(s):  
Rna Editing ◽  
Human Disease

The RNA editing enzymes ADARs: mechanism of action and human disease

2014 ◽  
Vol 356 (3) ◽  
pp. 527-532 ◽  
Author(s):  
Sara Tomaselli ◽  
Franco Locatelli ◽  
Angela Gallo
Keyword(s):  
Rna Editing ◽  
Mechanism Of Action ◽  
Human Disease

scholarly journals MultiEditR: An easy validation method for detecting and quantifying RNA editing from Sanger sequencing

2019 ◽  
Author(s):  
Mitchell Kluesner ◽  
Annette Arnold ◽  
Taga Lerner ◽  
Rafail Nikolaos Tasakis ◽  
Sandra Wüst ◽  
...  
Keyword(s):  
Rna Editing ◽  
Sanger Sequencing ◽  
Tumour Progression ◽  
Cost Effective ◽  
Base Change ◽  
Rna Seq ◽  
Multiple Sources ◽  
Base Editing ◽  
Cost Effective Method ◽  
Apobec Family

ABSTRACTRNA editing is the base change that results from RNA deamination by two predominant classes of deaminases; the APOBEC family and the ADAR family. Respectively, deamination of nucleobases by these enzymes are responsible for endogenous editing of cytosine to uracil (C-to-U) and adenosine to inosine (A-to-I). RNA editing is known to play an essential role both in maintaining normal cellular function, as well as altered cellular physiology during oncogenesis and tumour progression. Analysis of RNA editing in these important processes, largely relies on RNA-seq technology for the detection and quantification of RNA editing sites. Despite the power of these technologies, multiple sources of error in detecting and measuring base editing still exist, therefore additional validation and quantification of editing through Sanger sequencing is still required for confirmation of editing. Depending on the number of RNA editing sites that are of interest, this validation step can be both expensive and time-consuming. To address this need we developed the tool MultiEditR which provides a simple, and cost-effective method of detecting and quantifying RNA editing form Sanger sequencing. We expect that MultiEditR will foster further discoveries in this rapidly expanding field.

scholarly journals The role of RNA editing enzyme ADAR1 in human disease

2021 ◽  
Author(s):  
Brian Song ◽  
Yusuke Shiromoto ◽  
Moeko Minakuchi ◽  
Kazuko Nishikura
Keyword(s):  
Rna Editing ◽  
Human Disease ◽  
Editing Enzyme

scholarly journals Adenosine-to-inosine RNA editing and human disease

10.1186/gm508 ◽  
2013 ◽  
Vol 5 (11) ◽  
pp. 105 ◽  
Author(s):  
William Slotkin ◽  
Kazuko Nishikura
Keyword(s):  
Rna Editing ◽  
Human Disease

Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business

2003 ◽  
Vol 19 (4) ◽  
pp. 207-216 ◽  
Author(s):  
Joseph E. Wedekind ◽  
Geoffrey S.C. Dance ◽  
Mark.P. Sowden ◽  
Harold C. Smith
Keyword(s):  
Rna Editing ◽  
Family Business ◽  
Messenger Rna ◽  
New Members ◽  
The Family ◽  
Apobec Family

scholarly journals A-to-I RNA Editing and Human Disease

RNA Biology ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Stefan Maas ◽  
Yukio Kawahara ◽  
Kristen M. Tamburro ◽  
Kazuko Nishikura
Keyword(s):  
Rna Editing ◽  
Human Disease

Use of Protein a Conjugated to Peroxidase to Localize Immunoglobulin G in SSPE Ferret Brain

1982 ◽  
Vol 40 ◽  
pp. 350-351
Author(s):  
Hannah R. Brown ◽  
Anthony F. Nostro ◽  
Halldor Thormar
Keyword(s):  
Immunoglobulin G ◽  
Human Disease ◽  
Measles Virus ◽  
Subacute Sclerosing Panencephalitis ◽  
Protein A ◽  
Inflammatory Lesions ◽  
Sspe Virus ◽  
Specific Immunoglobulin ◽  
Antibody Titers ◽  
The Brain

Subacute sclerosing panencephalitis (SSPE) is a slowly progressing disease of the CNS in children which is caused by measles virus. Ferrets immunized with measles virus prior to inoculation with the cell associated, syncytiogenic D.R. strain of SSPE virus exhibit characteristics very similar to the human disease. Measles virus nucleocapsids are present, high measles antibody titers are found in the sera and inflammatory lesions are prominent in the brains. Measles virus specific immunoglobulin G (IgG) is present in the brain,and IgG/ albumin ratios indicate that the antibodies are synthesized within the CNS.

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