scholarly journals The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging

Genes ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1415
Author(s):  
Robert Philibert ◽  
James A. Mills ◽  
Jeffrey D. Long ◽  
Sue Ellen Salisbury ◽  
Alejandro Comellas ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Healthy Aging ◽  
Contingency Management ◽  
Smoking History ◽  
Imaging Protocol ◽  
Smoking Intensity ◽  
Epigenetic Aging ◽  
Environmental Driver ◽  
Potential Tool ◽  
Smoking Cessation Therapy

Smoking is the largest preventable cause of mortality and the largest environmental driver of epigenetic aging. Contingency management-based strategies can be used to treat smoking but require objective methods of verifying quitting status. Prior studies have suggested that cg05575921 methylation reverts as a function of smoking cessation, but that it can be used to verify the success of smoking cessation has not been unequivocally demonstrated. To test whether methylation can be used to verify cessation, we determined monthly cg05575921 levels in a group of 67 self-reported smokers undergoing biochemically monitored contingency management-based smoking cessation therapy, as part of a lung imaging protocol. A total of 20 subjects in this protocol completed three months of cotinine verified smoking cessation. In these 20 quitters, the reversion of cg05575921 methylation was dependent on their initial smoking intensity, with methylation levels in the heaviest smokers reverting to an average of 0.12% per day over the 3-month treatment period. In addition, we found suggestive evidence that some individuals may have embellished their smoking history to gain entry to the study. Given the prominent effect of smoking on longevity, we conclude that DNA methylation may be a useful tool for guiding and incentivizing contingency management-based approaches for smoking cessation.

scholarly journals Alcohol Use Intensity Decreases in Response to Successful Smoking Cessation Therapy

Genes ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 2
Author(s):  
Robert Philibert ◽  
Kelsey Dawes ◽  
Willem Philibert ◽  
Allan M. Andersen ◽  
Eric A. Hoffman
Keyword(s):  
Smoking Cessation ◽  
Alcohol Consumption ◽  
Alcohol Use ◽  
Contingency Management ◽  
Smoking Intensity ◽  
Quit Smoking ◽  
Heavy Alcohol Consumption ◽  
Highly Correlated ◽  
The Relationship ◽  
Smoking Cessation Therapy

Smokers frequently drink heavily. However, the effectiveness of smoking cessation therapy for those with comorbid alcohol abuse is unclear, and the content of smoking cessation programs often does not address comorbid alcohol consumption. In order to achieve a better understanding of the relationship between changes in rate of smoking to the change in intensity of alcohol consumption, and the necessity for alcohol-specific programming for dual users, we quantified cigarette and alcohol consumption in 39 subjects undergoing a 3-month contingency management smoking cessation program using recently developed DNA methylation tools. Intake alcohol consumption, as quantified by the Alcohol T Score (ATS), was highly correlated with cg05575921 smoking intensity (adjusted R2 = 0.49) with 19 of the 39 subjects having ATS scores indicative of Heavy Alcohol Consumption. After 90 days of smoking cessation therapy, ATS values decreased with the change in ATS score being highly correlated with change in cg05575921 smoking intensity (adjusted R2 = 0.60), regardless of whether or not the subject managed to completely quit smoking. We conclude that alcohol consumption significantly decreases in response to successful smoking cessation. Further studies to determine whether targeted therapy focused on comorbid alcohol use increases the success of smoking cessation in those with dual use should be explored.

EFFECTS OF SMOKING ON THE DISEASE PROGNOSIS IN CANCER PATIENTS

2019 ◽  
Vol 65 (3) ◽  
pp. 321-329
Author(s):  
David Zaridze ◽  
Anush Mukeriya
Keyword(s):  
Smoking Cessation ◽  
Cancer Patients ◽  
Malignant Tumors ◽  
Scientific Data ◽  
Second Primary ◽  
Primary Tumors ◽  
Smoking Intensity ◽  
Risk Of Death ◽  
Disease Prognosis ◽  
Increased Risk

Smoking not only increases the risk of the development of malignant tumors (MT), but affects the disease prognosis, mortality and survivability of cancer patients. The link between the smoking of cancer patients and increased risk of death by all diseases and oncological causes has been established. Mortality increases with the growth of the smoking intensity, i.e. the number of cigarettes, smoked per day. Smoking is associated with the worst general and oncological survivability. The statistically trend-line between the smoking intensity and survivability was observed: each additional unit of cigarette consumption (pack/year) leads to the Overall Survival Reduction by 1% (p = 0.002). The link between smoking and the risk of developing second primary tumors has been confirmed. Smoking increases the likelihood of side effects of the antitumor therapy both drug therapy and radiation therapy and reduces the treatment efficacy. The smoking cessation leads to a significant improvement in the prognosis of a cancer patient. Scientific data on the negative effect of smoking on the prognosis of cancer patients have a major clinical importance. The treatment program for cancer patients should include science-based methods for the smoking cessation. The latter is fundamentally important, taking into account that the smoking frequency among cancer patients is much higher than in the population.

Contingency management for smoking cessation among individuals with substance use disorders: In-treatment and post-treatment effects

2021 ◽  
Vol 119 ◽  
pp. 106920
Author(s):  
G. Aonso-Diego ◽  
A. González-Roz ◽  
A. Krotter ◽  
A. García-Pérez ◽  
R. Secades-Villa
Keyword(s):  
Smoking Cessation ◽  
Substance Use ◽  
Substance Use Disorders ◽  
Treatment Effects ◽  
Contingency Management ◽  
Post Treatment

Degree of atherosclerosis predicts short-term commitment for smoking cessation therapy

2004 ◽  
Vol 39 (1) ◽  
pp. 142-146 ◽  
Author(s):  
Mirko Hirschl ◽  
Claudia Francesconi ◽  
Maria Chudik ◽  
Reinhold Katzenschlager ◽  
Michael Kundi
Keyword(s):  
Smoking Cessation ◽  
Short Term ◽  
Smoking Cessation Therapy

scholarly journals Multicomponent Smoking Cessation Treatment Including Mobile Contingency Management in Homeless Veterans

2015 ◽  
Vol 76 (07) ◽  
pp. 959-964 ◽  
Author(s):  
Vickie L. Carpenter ◽  
Jeffrey S. Hertzberg ◽  
Angela C. Kirby ◽  
Patrick S. Calhoun ◽  
Scott D. Moore ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Contingency Management ◽  
Smoking Cessation Treatment ◽  
Homeless Veterans ◽  
Cessation Treatment

scholarly journals Reinforcer pathology and response to contingency management for smoking cessation.

2020 ◽  
Vol 34 (1) ◽  
pp. 156-163 ◽  
Author(s):  
Alba González-Roz ◽  
Ángel García-Pérez ◽  
Sara Weidberg ◽  
Gema Aonso-Diego ◽  
Roberto Secades-Villa
Keyword(s):  
Smoking Cessation ◽  
Contingency Management

scholarly journals The estimated effect of graphic warning labels on smoker’s intention to quit in Shanghai, China: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruiping Wang ◽  
Yan Qiang ◽  
Yan Zhu ◽  
Xiangjin Gao ◽  
Qiong Yang ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Logistic Regression ◽  
Control Measures ◽  
Intention To Quit ◽  
Lower Percentage ◽  
Warning Labels ◽  
Cross Sectional ◽  
Smoking Intensity ◽  
Graphic Warning ◽  
Cigarette Packs

Abstract Background Tobacco consumption is the leading cause of death worldwide. Overwhelming studies demonstrate graphic warning labels (GWLs) on cigarette packs are effective in eliciting negative response to tobacco smoking, modifying beliefs about tobacco dangers, and increasing reported intention to quit, but the estimated effect of GWLs on smoking cessation intention among smokers is still limited in China. In this study, we aim to understand the smoking intensity, smoking duration and smoking cessation intention among current smokers, and to explore how their smoking cessation intention would be influenced by the GWLs in Shanghai. Methods From January to June 2021, we totally recruited 1104 current smokers in Songjiang district and Fengxian district of Shanghai by multistage sampling design. We used Android pad assisted electronic questionnaire for data collection, and then implemented logistic regression for odds ratio (OR) and 95% confidence interval (CI) calculation to explore how smoking cessation intention would be influenced by the GWLs among current smokers. Results One thousand one hundred four current smokers included 914 males (82.79%), with an average age of 43.61 years. 58.06% of current smokers reported smoking cessation intention due to GWLs. Logistic regression indicated a higher percentage of smoking cessation intention due to GWLs was among female smokers [OR = 2.41, 95% CI (1.61–3.59)], smokers with smoking intensity < 20 cigarette/day [OR = 1.92, 95% CI (1.44–2.55)], smokers with tobacco burden < 20% [OR = 1.94, 95% CI (1.35–2.79)], and among smokers had plan to quit in a year [OR = 6.58, 95% CI (4.71–9.18). Smokers with higher individual monthly income had lower percentage of smoking cessation intention (OR were 0.35, 0.46 and 0.41). Meanwhile, among 642 current smokers without plan to quit in a year, approximately 40% of them reported smoking cessation intention due to GWLs. Conclusions Smoking cessation intention due to the assumed GWLs on cigarette packs is high among current smokers in Shanghai, especially in female smokers, smokers with light tobacco burden and mild nicotine dependence. Incorporating smoking intensity as well as smoking burden into the implementation of GWLs as tobacco control measures would discourage smoking in China.

Sign in / Sign up

Export Citation Format

Share Document