scholarly journals Severe ME in Children

Healthcare ◽  
2020 ◽  
Vol 8 (3) ◽  
pp. 211 ◽  
Author(s):  
Nigel Speight
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Personal Experience ◽  
Current Problem ◽  
Clinical Presentation ◽  
Case Reports ◽  
Chronic Fatigue ◽  
Limited Data ◽  
Additional Problem ◽  
Fatigue Syndrome ◽  
A Current

A current problem regarding Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is the large proportion of doctors that are either not trained or refuse to recognize ME/CFS as a genuine clinical entity, and as a result do not diagnose it. An additional problem is that most of the clinical and research studies currently available on ME are focused on patients who are ambulant and able to attend clinics and there is very limited data on patients who are very severe (housebound or bedbound), despite the fact that they constitute an estimated 25% of all ME/CFS cases. This author has personal experience of managing and advising on numerous cases of severe paediatric ME, and offers a series of case reports of individual cases as a means of illustrating various points regarding clinical presentation, together with general principles of appropriate management.

scholarly journals Long COVID and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)—A Systemic Review and Comparison of Clinical Presentation and Symptomatology

Medicina ◽  
2021 ◽  
Vol 57 (5) ◽  
pp. 418
Author(s):  
Timothy L. Wong ◽  
Danielle J. Weitzer
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Literature Search ◽  
Clinical Presentation ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Systemic Review ◽  
Future Research ◽  
Medical Illness ◽  
Case Definitions ◽  
Fatigue Syndrome

Background and Objectives: Long COVID defines a series of chronic symptoms that patients may experience after resolution of acute COVID-19. Early reports from studies with patients with long COVID suggests a constellation of symptoms with similarities to another chronic medical illness—myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). A review study comparing and contrasting ME/CFS with reported symptoms of long COVID may yield mutualistic insight into the characterization and management of both conditions. Materials and Methods: A systemic literature search was conducted in MEDLINE and PsycInfo through to 31 January 2021 for studies related to long COVID symptomatology. The literature search was conducted in accordance with PRISMA methodology. Results: Twenty-one studies were included in the qualitative analysis. Long COVID symptoms reported by the included studies were compared to a list of ME/CFS symptoms compiled from multiple case definitions. Twenty-five out of 29 known ME/CFS symptoms were reported by at least one selected long COVID study. Conclusions: Early studies into long COVID symptomatology suggest many overlaps with clinical presentation of ME/CFS. The need for monitoring and treatment for patients post-COVID is evident. Advancements and standardization of long COVID research methodologies would improve the quality of future research, and may allow further investigations into the similarities and differences between long COVID and ME/CFS.

Premorbid Functioning, Welfare Issues and Ethics in Chronic Fatigue Syndrome

2003 ◽  
Vol 11 (3) ◽  
pp. 312-318
Author(s):  
Chris Cantor ◽  
Kerryn Neulinger
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Ethical Issues ◽  
Case Reports ◽  
Chronic Fatigue ◽  
Exercise Intolerance ◽  
Systematic Research ◽  
Activity Levels ◽  
Subjective Memory ◽  
Fatigue Syndrome ◽  
Premorbid Functioning

Objective: To assess former activity levels in chronic fatigue syndrome (CFS) subjects, identify differentiating variables and discuss ethical issues arising. Method: File review of 91 CFS patients from a private psychiatric practice, presenting multiple case reports, with limited case comparison data. Results: The CFS subjects appeared formerly more athletically inclined than controls. Other helpful differentiating variables included exercise intolerance, excessive need for sleep, hopefulness and subjective memory problems. Conclusions: Former exercise and other achievement levels warrant systematic research study and consideration in the assessment of CFS patients. Omissions of consideration of premorbid functioning in medicolegal evaluations raise ethical concerns.

Efficacy of a half dose of oral pyridostigmine in the treatment of chronic fatigue syndrome: three case reports

2003 ◽  
Vol 9 (3) ◽  
pp. 189-194 ◽  
Author(s):  
Yasuo Kawamura ◽  
Mikihiro Kihara ◽  
Kazuhiro Nishimoto ◽  
Mayumi Taki
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Case Reports ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
Half Dose

Use of anti HHV-6 transfer factor for the treatment of two patients with chronic fatigue syndrome (CFS). Two case reports

Biotherapy ◽  
1996 ◽  
Vol 9 (1-3) ◽  
pp. 81-86 ◽  
Author(s):  
Dharam V. Ablashi ◽  
Paul H. Levine ◽  
Caterina De Vinci ◽  
James E. Whitman ◽  
Giancarlo Pizza ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Transfer Factor ◽  
Case Reports ◽  
Chronic Fatigue ◽  
Fatigue Syndrome

scholarly journals Low-dose naltrexone as a treatment for chronic fatigue syndrome

2020 ◽  
Vol 13 (1) ◽  
pp. e232502 ◽  
Author(s):  
Monica Jane Bolton ◽  
Bryan Paul Chapman ◽  
Harm Van Marwijk
Keyword(s):  
Clinical Trials ◽  
Chronic Fatigue Syndrome ◽  
Low Dose ◽  
Case Reports ◽  
Chronic Fatigue ◽  
Small Scale ◽  
Fatigue Syndrome ◽  
Low Dose Naltrexone ◽  
Potential Use

Naltrexone is used as an off-label treatment in low doses for several chronic immune-modulated disorders in many countries. Although only small-scale clinical trials have been performed, these suggest efficacy in several diseases including Crohn’s disease, fibromyalgia and Gulf War Illness. Despite numerous internet reports of response to low-dose naltrexone (LDN), no clinical trials exist in people with chronic fatigue syndrome. This condition is characterised by chronic profound fatigue, postexertional malaise, pain and autonomic and neurocognitive disturbances. This series of three case reports compiled by people with long-term ill-health due to chronic fatigue syndrome shows the range of responses they observed when taking LDN, from life changing to a reduction in some symptoms only. Treatment doses ranged from 4 to 12 mg. Clinical trials may be warranted to explore the potential use of naltrexone in people with these debilitating illnesses which currently have no licensed treatments available.

Long- and short-term blood pressure andRR-interval variability and psychosomatic distress in chronic fatigue syndrome: authors’ reply 1

1999 ◽  
Vol 97 (3) ◽  
pp. 319 ◽  
Author(s):  
D.A. DUPREZ ◽  
M.L. DE BUYZERE ◽  
B. DRIEGHE ◽  
F. VANHAVERBEKE ◽  
Y. TAES ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Short Term ◽  
Fatigue Syndrome

Diagnostic Concordance Between Categorical and Dimensional Instruments to Assess Personality Disorder in Chronic Fatigue Syndrome

2017 ◽  
Vol 33 (3) ◽  
pp. 158-165
Author(s):  
Natalia Calvo ◽  
Naia Sáez-Francàs ◽  
Sergi Valero ◽  
Jesús Castro-Marrero ◽  
José Alegre Martín ◽  
...  
Keyword(s):  
Personality Disorder ◽  
Chronic Fatigue Syndrome ◽  
Personality Assessment ◽  
Chronic Fatigue ◽  
Specific Pattern ◽  
Harm Avoidance ◽  
Assessment Instrument ◽  
Compulsive Disorder ◽  
Fatigue Syndrome ◽  
Self Transcendence

Abstract. The study examines the relationship between a categorical and a dimensional personality assessment instrument in patients with Chronic Fatigue Syndrome (CFS). A total of 162 CFS patients were included in the study (91.4% women; mean age 47.5 years). All subjects completed the Spanish versions of the Personality Diagnostic Questionnaire-4+ (PDQ-4+) and the Temperament and Character Inventory-Revised (TCI-R). Results: 78 (48.1%) of the patients presented a Personality Disorder (PD), the most frequent being Cluster C, specifically Obsessive-compulsive disorder, followed by Avoidant disorder. PDs showed a specific pattern of correlation with temperament scales. All PD clusters correlated positively with Harm Avoidance and Self-Transcendence, and negatively with Reward Dependence, Self-Directedness, and Cooperativeness. In a logistic regression analysis, Self-Directedness and Cooperativeness predicted PD presence. The findings are consistent with previous studies in non-CFS samples and suggest that the combination of the Temperament and Character dimensions (low Self-Directedness and Cooperativeness and high Harm Avoidance and Self-Transcendence) correlates with PD severity, and that Self-Directedness and Cooperativeness are associated with PD presence in CFS patients. The integration of these two perspectives expands the current comprehension of personality pathology in CFS patients.

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