New Targets for PET Imaging of Myeloma

Hemato ◽  
2021 ◽  
Vol 2 (4) ◽  
pp. 727-738
Author(s):  
Mona-Elisabeth Revheim ◽  
Caroline Stokke ◽  
Jakob Nordberg Nørgaard ◽  
Hilde Feiring Phillips ◽  
Alexander Gul Sherwani ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Residual Disease ◽  
Imaging Modality ◽  
Ct Imaging ◽  
New Targets ◽  
Pet Tracer ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Recent advances in the treatment of multiple myeloma (MM) have increased the need for accurate diagnosis and detection of minimal residual disease (MRD), disease characterization and localization, and response evaluation and prognostication. Positron emission tomography (PET)/computed tomography (CT) imaging combines molecular and morphological information and has been shown to be especially valuable in this disease. The most frequently used PET tracer in MM is the glucose analog 18F-fluorodeoxyglucose ([18F]FDG). [18F]FDG PET/CT has a sensitivity for detection of MM between 80% to 100% and is currently the main imaging modality for assessing treatment response and for determining MRD. However, 18F-FDG PET/CT has some limitations, and imaging with alternative tracers that may overcome these constraints should be further explored. This article discusses new targets for PET/CT imaging in the assessment of MM.

Time-Related Aortic Inflammatory Response, As Assessed With 18F-FDG PET/CT, in Patients Hospitalized With Severe or Critical COVID-19 The COVAIR Study

2021 ◽  
Author(s):  
Charalambos Vlachopoulos ◽  
Dimitrios Terentes - Printzios ◽  
Paraskevi Katsaounou ◽  
Eirini Solomou ◽  
Vassiliki Gardikioti ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Control Group ◽  
Prior History ◽  
Fdg Uptake ◽  
Positron Emission ◽  
Pet Ct ◽  
Arterial Inflammation ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract AimArterial involvement has been implicated in the coronavirus disease of 2019 (COVID-19). 18F-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) imaging is a valuable tool for the assessment of disease severity in different types of vasculitis and is a predictor of outcome. We sought to prospectively assess the presence of aortic inflammation and its time-dependent trend by measuring the 18-FDG uptake in PET/CT in patients with severe or critical COVID-19.Methods In this pilot case control study, we recruited 20 patients, who were admitted with severe or critical COVID-19 illness. Patients underwent imaging between 20 to 120 days after hospital admission. Ten age- and sex-matched individuals with prior history of malignancy but free of active disease served as the control group. Arterial inflammation was assessed by measuring 18-FDG uptake in PET/CT and calculating aortic target to blood ratio (TBR).ResultsThere was a significant correlation between aortic TBR values and time distance from diagnosis to 18F-FDG PET/CT scan (-rho- =0.547, p=0.015) even after adjustment for confounders (p=0.002). Patients who were scanned less than 60 days (median) from diagnosis had significantly higher TBR values compared to patients examined more than 60 days post-diagnosis (1.55 [1.47-1.61] vs 1.40 [1.33-1.45], respectively, p=0.013).ConclusionThis is the first study suggesting that 18 FDG PET/CT imaging could be used for assessment of arterial inflammation in patients with severe/critical COVID-19. These findings may have important implications for the understanding of the pathophysiology and the course of the disease and for improving our preventive and therapeutic strategies.

scholarly journals 18F-FDG PET/CT imaging findings of multiple solitary fibrous tumor

Medicine ◽  
2019 ◽  
Vol 98 (32) ◽  
pp. e16743
Author(s):  
Xiaofei Liu ◽  
Wenhua Zhu ◽  
Xiaohong Zhou ◽  
Hao Yao ◽  
Jiagui Su ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Imaging Findings ◽  
Pet Ct ◽  
18F Fdg ◽  
Fibrous Tumor ◽  
Fdg Pet Ct

scholarly journals Hibernoma: 18F FDG PET/CT Imaging

2007 ◽  
Vol 2 (6) ◽  
pp. 569-570 ◽  
Author(s):  
Rathan M. Subramaniam ◽  
Amy C. Clayton ◽  
Dimitrios Karantanis ◽  
Douglas A. Collins
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

Low positive yield from routine inclusion of the brain in whole-body 18F-FDG PET/CT imaging for noncerebral malignancies

2013 ◽  
Vol 34 (6) ◽  
pp. 540-543 ◽  
Author(s):  
Kuruva Manohar ◽  
Anish Bhattacharya ◽  
Bhagwant R. Mittal
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Whole Body ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
The Brain

scholarly journals 18F-FDG PET/CT Imaging In Oncology

2011 ◽  
Vol 31 (1) ◽  
pp. 3-13 ◽  
Author(s):  
Ahmad Almuhaideb ◽  
Nikolaos Papathanasiou ◽  
Jamshed Bomanji
Keyword(s):  
Fdg Pet ◽  
Ct Imaging ◽  
Pet Ct ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Pulmonary Findings of [18F]FDG PET/CT Images on Asymptomatic COVID-19 Patients

Pathogens ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 839
Author(s):  
Tzu-Chuan Ho ◽  
Chin-Chuan Chang ◽  
Hung-Pin Chan ◽  
Ying-Fong Huang ◽  
Yi-Ming Arthur Chen ◽  
...  
Keyword(s):  
Systematic Review ◽  
Fdg Pet ◽  
Standardized Uptake Value ◽  
Fdg Uptake ◽  
Asymptomatic Patients ◽  
Positron Emission ◽  
Pet Ct ◽  
18F Fdg ◽  
Maximal Standardized Uptake Value ◽  
Fdg Pet Ct

During the coronavirus disease 2019 (COVID-19) pandemic, several case studies demonstrated that many asymptomatic patients with COVID-19 underwent fluorine-18 fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT) examination for various indications. However, there is a lack of literature to characterize the pattern of [18F]FDG PET/CT imaging on asymptomatic COVID-19 patients. Therefore, a systematic review to analyze the pulmonary findings of [18F]FDG PET/CT on asymptomatic COVID-19 patients was conducted. This systematic review was performed under the guidelines of PRISMA. PubMed, Medline, and Web of Science were used to search for articles for this review. Articles with the key words: “asymptomatic”, “COVID-19”, “[18F]FDG PET/CT”, and “nuclear medicine” were searched for from 1 January 2020 to 20 May 2021. Thirty asymptomatic patients with COVID-19 were included in the eighteen articles. These patients had a mean age of 62.25 ± 14.85 years (male: 67.71 ± 12.00; female: 56.79 ± 15.81). [18F]FDG-avid lung lesions were found in 93.33% (28/30) of total patients. The major lesion was [18F]FDG-avid multiple ground-glass opacities (GGOs) in the peripheral or subpleural region in bilateral lungs, followed by the consolidation. The intensity of [18F]FDG uptake in multiple GGOs was 5.605 ± 2.914 (range from 2 to 12) for maximal standardized uptake value (SUVmax). [18F]FDG-avid thoracic lymph nodes (LN) were observed in 40% (12/40) of the patients. They mostly appeared in both mediastinal and hilar regions with an SUVmax of 5.8 ± 2.93 (range from 2.5 to 9.6). The [18F]FDG uptake was observed in multiple GGOs, as well as in the mediastinal and hilar LNs. These are common patterns in PET/CT of asymptomatic patients with COVID-19.

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