Involvement of FGFR4 Gene Variants on the Clinicopathological Severity in Urothelial Cell Carcinoma

Fibroblast growth factor receptor 4 (FGFR4) plays a prominent role in cell proliferation and cancer progression. This study explored the effect of FGFR4 single-nucleotide polymorphisms (SNPs) on the clinicopathological characteristics of urothelial cell carcinoma (UCC). This study was conducted to survey the possible correlation of the polymorphism of FGFR4 to the risk and clinicopathologic characteristics of UCC. Four loci of FGFR4 (rs2011077 T > C, rs351855 G > A, rs7708357 G>A, and rs1966265 A > G) were genotyped via the TaqMan allelic discrimination approach in 428 UCC cases and 856 controls. The results indicated that UCC subjects who carried the SNP rs2011077 TC+CC genotypes were significantly related to a higher tumor stage (odds ratio (OR): 1.751, 95% confidence interval (CI): 1.078–2.846), primary tumor size (OR: 1.637, 95% CI: 1.006–2.662), and histopathologic grading (OR: 1.919, 95% CI: 1.049–3.511). Moreover, the SNP rs1966265 AG+GG genotypes were prominently related to a higher tumor stage (OR: 1.769, 95% CI: 1.082–2.891), primary tumor size (OR: 1.654, 95% CI: 1.011–2.706), and histopathologic grading (OR: 2.006, 95% CI: 1.096–3.674) compared to individuals with AA homozygotes. In conclusion, our data reveal association of FGFR4 polymorphisms with UCC clinicopathologic characteristics. FGFR4 polymorphisms may serve as a marker or therapeutic target in UCC development.

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Impact of Long Non-Coding RNA HOTAIR Genetic Variants on the Susceptibility and Clinicopathologic Characteristics of Patients with Urothelial Cell Carcinoma

Journal of Clinical Medicine ◽

10.3390/jcm8030282 ◽

2019 ◽

Vol 8 (3) ◽

pp. 282 ◽

Cited By ~ 10

Author(s):

Min-Che Tung ◽

Yu-Ching Wen ◽

Shian-Shiang Wang ◽

Yung-Wei Lin ◽

Jyh-Ming Chow ◽

...

Keyword(s):

Bladder Cancer ◽

Survival Rate ◽

Cell Carcinoma ◽

Smoking Habit ◽

Tobacco Consumption ◽

Urothelial Cell ◽

Urothelial Cell Carcinoma ◽

Clinicopathologic Characteristics ◽

Allelic Discrimination ◽

Non Coding Rna

Increasing evidence shows that dysregulated expression of long non-coding (lnc)RNAs can serve as diagnostic or prognostic markers in urothelial cell carcinoma (UCC), the most common pathological type of bladder cancer. lncRNA HOX transcript antisense RNA (HOTAIR) was shown to promote tumor progression and be associated with a poor prognosis in multiple cancers including bladder cancer. Polymorphisms of HOTAIR were recently linked to a predisposition for diverse malignancies. Herein we conducted a case-control study to evaluate whether genetic polymorphisms of HOTAIR were associated with UCC risk and clinicopathologic characteristics. Four loci (rs920778 T>C, rs1899663 G>T, rs4759314 A>G, and rs12427129, C>T) of HOTAIR were genotyped by a TaqMan allelic discrimination method in 431 cases and 862 controls. We found that female patients who carried AG + GG genotype of rs4759314 were associated with an increased UCC risk after controlling for age and tobacco consumption (adjusted odds ratio (AOR) = 1.92, 95% confidence interval (CI): 1.01–3.64, p = 0.047) and a lower overall survival rate (p = 0.008). Moreover, patients with a smoking habit or younger age (≤65 years), who had at least one T allele of HOTAIR rs12427129 were at a higher risk of developing advance tumor T satge (p = 0.046), compared to those patients with CC homozygotes. In contrast, rs920778 C allele carriers were negatively correlated with the development of lymph node metastasis (OR = 0.51, 95% CI: 0.28–0.94, p = 0.031). Further analyses of clinical datasets revealed correlations of the expression of HOTAIR with tumor metastasis and a poor survival rate in patients with UCC. Our results verified the diverse impacts of HOTAIR variants on UCC susceptibility and clinicopathologic characteristics.

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Early Primary Tumor Size Reduction Is an Independent Predictor of Improved Overall Survival in Metastatic Renal Cell Carcinoma Patients Treated With Sunitinib

European Urology ◽

10.1016/j.eururo.2011.07.008 ◽

2011 ◽

Vol 60 (6) ◽

pp. 1273-1279 ◽

Cited By ~ 59

Author(s):

E. Jason Abel ◽

Stephen H. Culp ◽

Nizar M. Tannir ◽

Pheroze Tamboli ◽

Surena F. Matin ◽

...

Keyword(s):

Renal Cell Carcinoma ◽

Overall Survival ◽

Cell Carcinoma ◽

Metastatic Renal Cell Carcinoma ◽

Tumor Size ◽

Primary Tumor ◽

Renal Cell ◽

Independent Predictor ◽

Primary Tumor Size ◽

Early Primary

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Impact of RAGE gene polymorphisms on urothelial cell carcinoma clinicopathologic characteristics and long term survival

European Urology Supplements ◽

10.1016/s1569-9056(19)31052-8 ◽

2019 ◽

Vol 18 (1) ◽

pp. e1461

Author(s):

H. Sheng-Chun ◽

S-S. Wang ◽

J-R. Li ◽

C-S. Chen ◽

L.W. Chang ◽

...

Keyword(s):

Cell Carcinoma ◽

Gene Polymorphisms ◽

Urothelial Cell ◽

Urothelial Cell Carcinoma ◽

Clinicopathologic Characteristics ◽

Term Survival ◽

Long Term Survival

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Impact of Gene Polymorphisms in GAS5 on Urothelial Cell Carcinoma Development and Clinical Characteristics

Diagnostics ◽

10.3390/diagnostics10050260 ◽

2020 ◽

Vol 10 (5) ◽

pp. 260 ◽

Cited By ~ 1

Author(s):

Wei-Chun Weng ◽

Chih-Jung Chen ◽

Pei-Ni Chen ◽

Shian-Shiang Wang ◽

Ming-Ju Hsieh ◽

...

Keyword(s):

Cell Carcinoma ◽

Tumor Size ◽

Noncoding Rna ◽

Cohort Analysis ◽

Critical Role ◽

Growth Arrest ◽

Urothelial Cell ◽

Rank Test ◽

Urothelial Cell Carcinoma ◽

Female Patients

Urothelial cell carcinoma (UCC) is the commonest malignant tumor of the urinary tract and the second most common kidney cancer malignancy. Growth arrest-specific 5 (GAS5), a long noncoding RNA, is encoded by the GAS5 gene and plays a critical role in cellular growth arrest and apoptosis. In the current study, two single nucleotide polymorphisms (SNPs) in the GAS5 gene, rs145204276 and rs55829688, were selected to investigate correlations between these single SNPs and susceptibility to UCC. A total of 430 UCC cases and 860 ethnically matched healthy controls were included. SNP rs145204276 and SNP rs55829688 were determined using a TaqMan genotyping assay. Logistic regression models demonstrated that female patients with UCC carrying the rs145204276 GAS5 Ins/Del or Del/Del genotype had a 3.037-fold higher risk of larger tumor status (95% confidence interval 1.259–7.324) than did rs145204276 wild type (Ins/Ins) carriers (p = 0.011). The Cancer Genome Atlas validation cohort analysis demonstrated that the expression of GAS5 in female patients with bladder urothelial carcinoma (BLCA) with larger tumor size was much lower than that in patients with a smaller tumor size (p = 0.041). Kaplan-Meier curve analysis and the log–rank test revealed that female patients with BLCA and lower GAS5 expression had poorer overall survival than those with higher GAS5 expression. In conclusion, genetic variations in GAS5 rs145204276 may serve as a critical predictor of the clinical status of female patients with UCC.

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Impacts of ICAM-1 gene polymorphisms on urothelial cell carcinoma susceptibility and clinicopathologic characteristics in Taiwan

Tumor Biology ◽

10.1007/s13277-014-1934-9 ◽

2014 ◽

Vol 35 (8) ◽

pp. 7483-7490 ◽

Cited By ~ 2

Author(s):

Shian-Shiang Wang ◽

Ming-Ju Hsieh ◽

Yen-Chuan Ou ◽

Chuan-Shu Chen ◽

Jian-Ri Li ◽

...

Keyword(s):

Cell Carcinoma ◽

Gene Polymorphisms ◽

Urothelial Cell ◽

Urothelial Cell Carcinoma ◽

Clinicopathologic Characteristics

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Clinico-epidemiologic characteristics and patterns of care in Merkel cell carcinoma: Data from a single-institution series.

Journal of Clinical Oncology ◽

10.1200/jco.2017.35.15_suppl.e21049 ◽

2017 ◽

Vol 35 (15_suppl) ◽

pp. e21049-e21049

Author(s):

Michael Del Rosario ◽

Eric Anderson ◽

Yani Lu ◽

Stephanie Farrell ◽

Steven C. Plaxe ◽

...

Keyword(s):

Lymph Node ◽

Statistical Analysis ◽

Cell Carcinoma ◽

Lymph Node Dissection ◽

Merkel Cell Carcinoma ◽

Tumor Size ◽

Primary Tumor ◽

Merkel Cell ◽

Node Dissection ◽

Primary Tumor Size

e21049 Background: Merkel cell carcinoma (MCC) is associated with increased sun exposure. There is an average of 348 days of sunshine per year in our geographic area. Methods: With the IRB approval, we performed a retrospective chart review of all consecutive MCC patients seen at our institution between 2006-2017. Clinico-epidemiologic data such as age, gender, race, stage, tumor size, stage at presentation, and disease course were collected. Therapy and survival were analyzed. Using the surveillance, epidemiology, and end results program (SEER), we identified 4,256 patients with MCC from the years 2006-2013. We compared our data with the SEER findings . Statistical analysis: Chi-square and Fishers’ exact tests were used to assess the significance of associations in large and small populations, respectively. Survival analyses were performed using the Cox proportional hazards. Results: We identified 40 patients with MCC (n = 40) with a median age of 77. Compared to SEER data, our population was entirely Caucasian (100% vs. 95%; p = 0.11) and male predominant (75% vs. 63%; p = 0.11). The patients in our cohort were diagnosed more often with TNM stage I (50% vs. 39%; p = 0.00003) and found to have more often a primary tumor size < 2cm (58% vs. 34%; p < 0.01). Our patients were more frequently treated with lymph node dissection (70% vs. 63%, p = 0.002) and radiation therapy (60% vs. 50%; p = 0.24). Conclusions: Compared to the general population, MCC patients treated at our institution had similar mean age at diagnosis, gender and racial distribution and radiation treatment frequency (all p-values > 0.05). However, our patient population was significantly more likely to be diagnosed at stage I disease, have a primary tumor size less than 2 cm and receive lymph node dissection. Final statistical analysis, including survival analysis, and significance are to be discussed.

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