scholarly journals Veno-Venous Extracorporeal Membrane Oxygenation in COVID-19—Where Are We Now?

Author(s):  
Zbigniew Putowski ◽  
Anna Szczepańska ◽  
Marcelina Czok ◽  
Łukasz J. Krzych

The recent development in extracorporeal life support (ECLS) has created new therapeutic opportunities for critically ill patients. An interest in extracorporeal membrane oxygenation (ECMO), the pinnacle of ECLS techniques, has recently increased, as for the last decade, we have observed improvements in the survival of patients suffering from severe acute respiratory distress syndrome (ARDS) while on ECMO. Although there is a paucity of conclusive data from clinical research regarding extracorporeal oxygenation in COVID-19 patients, the pathophysiology of the disease makes veno-venous ECMO a promising option.

2021 ◽  
Vol 5 (10) ◽  
pp. 953-960
Author(s):  
Dini Ardiyani ◽  
Zen Ahmad

Acute lung injury and acute respiratory distress syndrome are characterized by rapid-onset respiratory failure following a variety of direct and indirect insults to the parenchyma or vasculature of the lungs. Extracorporeal membrane oxygenation is a form of extracorporeal life support where an external artificial circulator carries venous blood from the patient to a gas exchange device (oxygenator) where blood becomes enriched with oxygen and has carbon dioxide removed. This blood then re-enters the patients circulation. The potential advantages of ECMO over conventional manajement may extend beyond its role in supporting patients with ARDS. ECMO may facilitate and enhance the application of lung-protective ventilation by minimizing ventilator-induced lung injury.


2021 ◽  
Vol 5 (4) ◽  
pp. 890-897
Author(s):  
Dini Ardiyani ◽  
Zen Ahmad

Acute lung injury and acute respiratory distress syndrome are characterized by rapid-onset respiratory failure following a variety of direct and indirect insults to the parenchyma or vasculature of the lungs. Extracorporeal membrane oxygenation is a form of extracorporeal life support where an external artificial circulator carries venous blood from the patient to a gas exchange device (oxygenator) where blood becomes enriched with oxygen and has carbon dioxide removed. This blood then re-enters the patients circulation. The potential advantages of ECMO over conventional manajement may extend beyond its role in supporting patients with ARDS. ECMO may facilitate and enhance the application of lung-protective ventilation by minimizing ventilator-induced lung injury.


Author(s):  
Cara Agerstrand ◽  
Andrew Pellet

This chapter explains the utilization of venovenous extracorporeal membrane oxygenation (ECMO) for acute respiratory distress syndrome (ARDS). Venovenous ECMO provides respiratory support and is the most common ECMO configuration used during ARDS. Patient selection is of the utmost importance for successful use of ECMO. Patients being considered for venovenous ECMO for ARDS should meet criteria for severe ARDS. Best guidance can be taken from the Extracorporeal Life Support Organization recommendations and the multicenter Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome trial. The main contraindication to ECMO is any condition or organ dysfunction that would limit the overall benefit of ECMO, such as severe brain injury, metastatic cancer, or decompensated cirrhosis. Once the ECMO circuit is operational, ventilator settings must be optimized to protect the injured lungs by adhering to an ultra-lung-protective “lung rest” strategy.


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