scholarly journals Association between Blood Mercury Levels and Non-Alcoholic Fatty Liver Disease in Non-Obese Populations: The Korean National Environmental Health Survey (KoNEHS) 2012–2014

2021 ◽  
Vol 18 (12) ◽  
pp. 6412
Author(s):  
Yun-Jung Yang ◽  
Eun-Jung Yang ◽  
Kyoungjin Park ◽  
Subin Oh ◽  
Taehyen Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Environmental Health ◽  
Health Survey ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Blood Mercury ◽  
Obese Subjects ◽  
National Environmental ◽  
Alcoholic Fatty Liver Disease

Mercury is widely distributed in the environment, and a plausible association between mercury exposure and hepatic damage has been reported. Non-alcoholic fatty liver disease (NAFLD), which comprises a spectrum of liver diseases, has recently been recognized in non-obese subjects. However, there have been no studies on the relationship between internal mercury levels and NAFLD in non-obese individuals. Therefore, we investigated the association between blood mercury levels and NAFLD in non-obese subjects. Cross-sectional data (n = 5919) were obtained from the Korean National Environmental Health Survey (2012–2014). NAFLD was defined using the hepatic steatosis index (HSI). Blood mercury levels were log-transformed and divided into quartiles based on a weighted sample distribution. The association between blood mercury levels and NAFLD was analyzed using a multivariate logistic analysis after body mass index stratification. The geometric mean of blood mercury in the overweight group was significantly higher than that of the non-obese group (p < 0.001). The weighted frequencies of patients with NAFLD based on the HSI were 3.0–7.2% for the non-obese subjects and 52.3–63.2% for the overweight subjects. In the multivariate analysis, blood mercury levels were positively associated with NAFLD for both the overweight and non-obese groups (all p for trend < 0.001). Increased blood mercury levels are closely associated with NAFLD. In particular, mercury could be a risk factor for NAFLD in the non-obese population.

scholarly journals Urinary Phthalate Levels Associated with the Risk of Nonalcoholic Fatty Liver Disease in Adults: The Korean National Environmental Health Survey (KoNEHS) 2012–2014

2021 ◽  
Vol 18 (11) ◽  
pp. 6035
Author(s):  
Yun-Jung Yang ◽  
Taehyen Kim ◽  
Yeon-Pyo Hong
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Environmental Health ◽  
Nonalcoholic Fatty Liver Disease ◽  
Health Survey ◽  
Fatty Liver Disease ◽  
Experimental Studies ◽  
Nonalcoholic Fatty Liver ◽  
Korean Adults ◽  
National Environmental

The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Recent experimental studies suggested that phthalates might induce NAFLD. Therefore, this study aimed to investigate the relationship between phthalates metabolites and NAFLD in the human population. This cross-sectional analysis was performed using data from the Korean National Environmental Health Survey II (2012–2014) among Korean adults (n = 5800). NAFLD was diagnosed using the hepatic steatosis index (HSI) in the absence of other causes of chronic liver diseases. Among the participants (mean age 46 years, 47.5% male), the prevalence of NAFLD was associated with urinary levels of mono(2-ethyl-5-hydroxyhexyl) phthalate (MEHHP), mono-(2-ethyl-5-oxohexyl) phthalate, mono-(2-ethyl-5-carboxypentyl) phthalate, mono-benzyl phthalate (MBzP), and mono-n-butyl phthalate (MnBP) compared to the reference group. In the multivariate model, the odds ratios (ORs), 95% confidence interval (CI) for NAFLD were 1.33 (1.00–1.78) and 1.39 (1.00–1.92) in the 3rd and 4th quartile of MEHHP, respectively. Based on the study findings, high levels of urinary phthalates are associated with the prevalence of NAFLD in Korean adults. Further investigation is required to elucidate the causal relationship.

scholarly journals The association between urinary bisphenol A levels and nonalcoholic fatty liver disease in Korean adults: Korean National Environmental Health Survey (KoNEHS) 2015-2017

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Sang Joon An ◽  
Eun-Jung Yang ◽  
Subin Oh ◽  
Kyong Jin Park ◽  
Taehyen Kim ◽  
...  
Keyword(s):  
Liver Disease ◽  
Bisphenol A ◽  
Fatty Liver ◽  
Environmental Health ◽  
Nonalcoholic Fatty Liver Disease ◽  
Health Survey ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Diseases ◽  
National Environmental

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is becoming a global health problem. Bisphenol A (BPA), one of most widely used environmental chemicals, is suspected to be a contributor to the development NAFLD. This study was performed to examine the relationship between human BPA levels and risk of NAFLD. Methods The data (n = 3476 adults: 1474 men and 2002 women) used in this study were obtained from the Korean National Environmental Health Survey III (2015-2017). BPA levels were measured in urine samples. NAFLD was defined using hepatic steatosis index after exclusion of other causes of hepatic diseases. Results There was a significant linear relationship between the elevated urinary BPA concentrations and risk of NAFLD. In a univariate analysis, odds ratio (OR) of the highest quartile of urinary BPA level was 1.47 [95% confidence interval (CI) 1.11-1.94] compared to the lowest quartile. After adjusted with covariates, the ORs for NAFLD in the third and fourth quartiles were 1.31 [95% CI 1.03-1.67] and 1.32 [95% CI 1.03–1.70], respectively. Conclusions Urinary BPA levels are positively associated with the risk of NAFLD in adults. Further experimental studies are needed to understand the molecular mechanisms of BPA on NAFLD prevalence.

scholarly journals THE ROLE OF ZONULIN IN THE DEVELOPMENT OF LIVER FIBROSIS IN OBESE ADOLESCENTS

2021 ◽  
Vol 74 (1) ◽  
pp. 77-82
Author(s):  
Liudmyla K. Parkhomenko ◽  
Larysa A. Strashok ◽  
Margaryta A. Khomenko
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Ultrasound Examination ◽  
Model Assessment ◽  
Alcoholic Fatty Liver ◽  
Obese Adolescents ◽  
Obese Subjects ◽  
Alcoholic Fatty Liver Disease

The aim: To study the relationship between zonulin level and PNFI (pediatric non-alcoholic fatty liver disease fibrosis index) in obese adolescents. Material and methods: A total of fifty-nine obese subjects aged 12-17 years and thirteen healthy subjects were included in the study. Clinical, biochemical parameters, including serum zonulin, were examined and abdominal ultrasound examination was performed. For the assessment of liver fibrosis PNFI was calculated. Results: According to ultrasound examination 71,2% of obese adolescents had non-alcoholic fatty liver disease (NAFLD). Calculation of PNFI showed that 25,4% of obese subjects had fibrotic processes in the liver. Obese adolescents had significantly higher zonulin levels compared to normal weight peers – 91,8±3,1 vs 15,9±5,1 respectively (р<0,01). A significant positive correlation was established between zonulin levels and such parameters as body mass index, waist circumference / height ratio, triglycerides, very low-density lipoprotein cholesterol, insulin, homeostasis model assessment of insulin resistance, PNFI (p<0,05). Conclusions: The level of zonulin increases with an increase of the index for evaluating liver fibrosis (PNFI) in obese adolescents. This may indicate the effect of the state of the intestinal barrier on the development and progression of obesity-related liver pathology, namely NAFLD, in obese adolescents.

scholarly journals Difference in lifestyle and metabolic profile of non-alcoholic fatty liver disease with raised alanine amino-transferases between obese and non-overweight subjects

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mithun Sharma ◽  
Anand Kulkarni ◽  
Pramod Kumar ◽  
Vijay Bhaskar Nori ◽  
Nitin Jagtap ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Metabolic Profile ◽  
Significant Proportion ◽  
Obese Group ◽  
Alcoholic Fatty Liver ◽  
Obese Subjects ◽  
Alcoholic Fatty Liver Disease

Abstract A significant proportion of patients with non-alcoholic fatty liver disease (NAFLD) in Asian sub-continent are non-overweight and may have different underlying risk factors, lifestyles and metabolic profiles. Seven hundred fifty patients of NAFLD with raised alanine-amino-transferase (ALT) were divided into non-overweight and obese group based on their body mass index (BMI). Detailed dietary and lifestyle history were obtained through questionnaires and a detailed assessment of metabolic profile and liver stiffness was done. Normal BMI (< 23 kg/m2) was found in 6.6% patients, of which 69.5% had raised ALT. Though the intake of dietary fat and exercise pattern were not different amongst these groups, yet the amount of aerated drinks was higher in obese subjects (12 ± 17 vs. 7 ± 7.5 p = 0.005). Serum low-density lipoprotein (111 ± 25.6 vs. 127.7 ± 32.7 p = 0.04) and insulin resistance based on HOMA-IR > 2 were significantly higher in obese group (4.1 ± 0.36 vs. 2.0 ± 0.15 p = 0.001). Insulin resistance and dyslipidemia were prevalent in 12% and 25% non-overweight patients respectively. Metabolic syndrome was more common in obese subjects. In addition, magnetic resonance elastography showed higher mean liver fat in the obese group with similar hepatic fibrosis. Non-overweight patients with NAFLD had lower insulin resistance and prevalence of dyslipidaemia at similar dietary and exercise pattern.

scholarly journals Expression of NALPs in adipose and the fibrotic progression of non-alcoholic fatty liver disease in obese subjects

2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Rohini Mehta ◽  
Arpan Neupane ◽  
Lei Wang ◽  
Zachary Goodman ◽  
Ancha Baranova ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Obese Subjects ◽  
Alcoholic Fatty Liver Disease
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