The Influence of Hepatitis C Virus Infection on ORAL Health-Related Quality of Life in Patients with Oral Lichen Planus

Background: oral lichen planus (OLP) is a mucocutaneous disease that affects about 4% of the global population. Hepatitis C virus (HCV) was linked to lichen planus. The current study aimed to assess the impact of OLP associated or not with HCV infection on the oral health-related quality of life (OHRQoL). Methods: The study included patients diagnosed with OLP who filled in the Romanian version of OHIP-14 questionnaire at their first appointment and 6 months later, after the OLP treatment. A control group of OLP-free subjects similar as age and sex was also included in the study. Results: 68 patients with OLP and 46 controls were included in the study. The OHIP scores are significantly higher on OLP group than controls (p-value < 0.0001) and significantly reduced at 6-month follow-up (p-values: < 0.0001 pre- vs. post-treatment in OLP group). Patients with and without HCV associated with OLP demonstrated a similar oral quality of life (p-values > 0.05). Conclusions: the OHRQoL for patients suffering from OLP is compromised but is improved after treatment. The HCV associated with OLP did not influence the overall OHRQoL, but the patients who associate HCV reported more frequently aching in the mouth and discomfort eating food at six-month follow-up.

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Oral health–related quality of life in different clinical forms of oral lichen planus

Clinical Oral Investigations ◽

10.1007/s00784-019-02951-8 ◽

2019 ◽

Vol 24 (1) ◽

pp. 301-308 ◽

Cited By ~ 5

Author(s):

Ioanina Parlatescu ◽

Mihaela Tovaru ◽

Carmen Larisa Nicolae ◽

Ruxandra Sfeatcu ◽

Andreea Cristiana Didilescu

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Health Related Quality ◽

Clinical Forms ◽

Related Quality ◽

Health Related ◽

Oral Lichen

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Effect of personality traits on the oral health-related quality of life in patients with oral lichen planus undergoing treatment

Clinical Oral Investigations ◽

10.1007/s00784-020-03561-5 ◽

2020 ◽

Author(s):

Dvorak Gabriella ◽

Rappersberger Klemens ◽

Rausch-Fan Xiao-hui ◽

Bruckmann Corinna ◽

Hofmann Eva

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Personality Traits ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Oral Lichen

Abstract Objectives The aim of this study was to evaluate the relationship between personality traits and perceived treatment success in oral lichen planus. Material and methods A total of 53 patients with diagnosed oral lichen planus were evaluated at the time of diagnosis and along the course of their treatment. The visual analogue scale (VAS) was used for evaluating pain and burning sensation, along with an evaluation of the oral health-related quality of life (OHIP) and the clinical severity. In order to determine the personality trait, the NEO-FFI questionnaire was applied. Data were assessed with the statistical software Stata by a multiple linear regression. Results A significant relationship between the two personality traits: “conscientiousness” and “extraversion” and a perceived improvement in oral lichen planus could be observed. The higher the “conscientiousness,” the better the perceived oral health-related quality of life. Furthermore, “extraversion” had a significant influence on the improvement in clinical severity index (P < 0.05). Conclusions Personality traits, especially conscientiousness and extraversion, have a significant impact on the perception of therapeutic intervention in oral lichen planus. Clinical relevance As personalized patient management is gaining importance and psychosocial factors play a significant role in mucosal diseases, the patient’s psychological profile should be considered in the oral lichen planus management.

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Gender aspects in oral health-related quality of life of oral lichen planus patients

international journal of stomatology & occlusion medicine ◽

10.1007/s12548-015-0123-9 ◽

2015 ◽

Vol 8 (2) ◽

pp. 33-40 ◽

Cited By ~ 1

Author(s):

Gabriella Dvorak ◽

Babak Monshi ◽

Markus Hof ◽

Thomas Bernhart ◽

Corinna Bruckmann ◽

...

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Gender Aspects ◽

Oral Lichen

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Does the Clinical Form of Oral Lichen Planus (OLP) Influence the Oral Health–Related Quality of Life (OHRQoL)?

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph17186633 ◽

2020 ◽

Vol 17 (18) ◽

pp. 6633

Author(s):

Linda Daume ◽

Constance Kreis ◽

Lauren Bohner ◽

Johannes Kleinheinz ◽

Susanne Jung

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Health Related Quality ◽

Physical Pain ◽

Related Quality ◽

Health Related ◽

Oral Lichen

(1) Background: The aim of the study was to investigate the oral health–related quality of life (OHRQoL) of patients with oral lichen planus (OLP) and to evaluate differences between the various clinical forms of OLP. Specifically, the differences in OHRQoL, physical pain levels and eating restriction were assessed; (2) Methods: One hundred and twelve patients with clinical and histological features of OLP from the Department of Cranio-Maxillofacial Surgery of the Münster University Hospital participated in this prospective study. OHRQoL was analysed by using the German short version of the Oral Health Impact Profile (OHIP-14). Physical pain levels and restriction in eating were rated on visual analogue scales (VAS). The statistical analysis was performed using the Mann–Whitney U-Test and the chi-squared test with a significance level at p = 0.05; (3) Results: Group 1 consisted of patients with reticular OLP (n = 50) and group 2 of patients with atrophic, erosive-ulcerative or bullous OLP (n = 62). The average OHIP-14 score was 13.54 points and differed significantly between the two groups. There were significant differences in the domains “physical pain”, “psychological discomfort”, “physical disability” and “social disability”. The VAS “physical pain” score and “restriction in eating” score varied significantly between the clinical forms. Positive correlations were found between the OHIP-14 total scores and the VAS scores; (4) Conclusion: The OHRQoL is significantly limited in patients with OLP; especially, patients with erosive-ulcerative OLP are affected.

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Impact of Oral Lichen Planus on Oral Health-Related Quality of Life: A Systematic Review and Meta-Analysis

Clinics and Practice ◽

10.3390/clinpract11020040 ◽

2021 ◽

Vol 11 (2) ◽

pp. 272-286

Author(s):

Monal Yuwanati ◽

Shailesh Gondivkar ◽

Sachin C. Sarode ◽

Amol Gadbail ◽

Gargi S. Sarode ◽

...

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

The Impact ◽

Oral Lichen

Oral health-related quality of life (OR-QoL) measurement in patients with oral lichen planus (OLP) can provide valuable information for the optimal management of their clinical conditions. The main objective of the present study was to assess the OR-QoL of patients with OLP as measured by the short-form Oral Health Impact profile-14 (OHIP-14) questionnaire. PubMed/MEDLINE, ISI/Web of Science, clinical trial registry, Embase, Scopus, and grey literature (via Google Scholar and Scilit) were searched. Reviewers independently screened titles/abstracts, assessed full-text articles, extracted data, and appraised their quality. Random effect analysis along with subgroup analysis for age, gender, and clinical type was performed. Seventeen studies were included. Mean overall OH-QoL was 15.20, [95% CI 12.176, 18.231]; a higher OHIP-14 score was seen in OLP patients, resulting in poor OH-QoL. The impact of OLP on OH-QoL life was moderate as compared to healthy subjects. However, medical treatment of the disease improved the OH-QoL and thus reduced the impact of OLP on it. OH-QoL among patients with OLP is generally poor. Clinicians and physicians should consider the OH-QoL of these patients as part of patients’ evaluation and modulate the administered treatment based on the OH-QoL response.

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Assessment of oral health- related quality of life in patients with lichen planus during the course of treatment, using “Chronic Oral Mucosal Disease Questionnaire”

Brazilian Dental Science ◽

10.14295/bds.2021.v24i3.2461 ◽

2021 ◽

Vol 24 (3) ◽

Author(s):

Maryam Baharvand ◽

Maryam Jaberi ◽

Parisa Hajighasem ◽

Azadeh Ahmadieh

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Healing Process ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Oral Lichen

Objective: The aim of this study was to assess the oral health related quality of life in patients with oral lichen planus, using a Chronic Oral Mucosal Diseases Questionnaire (COMDQ) during a course of standard medical treatment. Material and Methods: In this experimental study, fifteen patients with oral lichen planus were entered the study and the COMDQ (a self reported questionnaire assessing different aspects of quality of life in individuals with chronic oral mucosal diseases), ), was used to assess the level of “Pain and functional limitation”, “Medication and treatment”, “Social emotional” and “Patient support” during the course of standard treatment. A data collection form including demographic information, type and location of the lesions, patients’ symptoms and level of healing process was completed. Patients were evaluated weekly during four weeks of treatment and COMDQ scores were documented. Data were analyzed, using ANOVA and Friedman statistical tests. Results: The mean score of the COMDQ questionnaire in lichen planus patients who completed the course of treatment, showed significant improvement (P < 0.001) after each week of therapy. Oral symptoms and the healing process of oral lesions showed improvement without any statistically significant changes among different weeks of therapy. “Pain and functional limitation”, “Medication and treatment” and “Patient Support” improved significantly during the treatment period (P<001); however, the “Social and emotional” aspect did not show significant changes over the course of medical management. Conclusion: Oral health-related quality of life in patients with oral lichen planus improved significantly during the course of medical treatment. Keywords Oral Lichen Planus; COMDQ; Quality of Life; Oral Health.

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Clinical characteristics of oral lichen planus and its causal context with dental restorative materials and oral health-related quality of life

BMC Oral Health ◽

10.1186/s12903-021-01622-z ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Linda Daume ◽

Constance Kreis ◽

Lauren Bohner ◽

Susanne Jung ◽

Johannes Kleinheinz

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Lichen Planus ◽

Oral Lichen Planus ◽

Health Related Quality ◽

Restorative Materials ◽

Related Quality ◽

Health Related ◽

Oral Lichen

Abstract Background The aim of this study was to investigate the influence of clinical characteristics and dental restorative materials on oral health-related quality of life in patients with oral lichen planus. In particular, the influences of amalgam and metals were investigated. Methods A total of 112 patients with clinical and histological features of oral lichen planus from the Department of Cranio-Maxillofacial Surgery at the University Hospital of Münster participated in this prospective study. Clinical parameters of oral lichen planus and the dental restorative materials used were evaluated. Oral health-related quality of life was investigated by using the short form of the German version of the Oral Health Impact Profile (OHIP-14). In addition, physical pain was rated on a visual analogue scale. Results The average OHIP-14 score was 13.54. A high correlation was seen between OHIP and pain. Likewise, higher OHIP-values were seen for male patients, and such as for those patients with non-reticular forms of oral lichen planus (OLP). A local form of OLP is more often seen on female patients, such as with the presence of reticular lichen. In regard to the restorations, the presence of composite restorations is correlated with a local lichen, whereas the presence of gold restorations is often seen with a generalized lichen. Furthermore, the grading of strength of association between mucosal lesion and amalgam/metal was tested. No significant differences revealed the analysis of the relationship between gender, clinical form of OLP, age, and presentation form between the 4 gradings of Thornhill. Conclusions The oral health-related quality of life is significantly limited in patients with oral lichen planus. But these OHIP scores are not influenced by the restorative materials. Here, pain severity is the most important aspect. We found no statistical differences in the clinical parameters between patients with amalgam or metal restoration and patients without these restorations. It is not necessary to replace amalgam fillings that are not in direct contact with mucosal surfaces.

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Association between Clinical Signs of Oral Lichen Planus and Oral Health-Related Quality of Life: A Preliminary Study

Dentistry Journal ◽

10.3390/dj8040113 ◽

2020 ◽

Vol 8 (4) ◽

pp. 113

Author(s):

Sasirin Yiemstan ◽

Sudaduang Krisdapong ◽

Pornpan Piboonratanakit

Keyword(s):

Quality Of Life ◽

Oral Health ◽

Oral Lichen Planus ◽

Clinical Severity ◽

Health Related Quality ◽

Related Quality ◽

Health Related ◽

Oral Lichen ◽

Oral Impacts

Subjective patient’s symptoms and Oral Health-Related Quality of Life (OHRQoL) are recommended to be involved in oral lichen planus (OLP) studies. This study aims to assess the OHRQoL of OLP patients, and their associations with pain and OLP in Thai patients. Sixty-nine patients were interviewed using the Numeric Rating Scale (NRS) for pain perception and Oral Impacts on Daily Performance (OIDP) index. OLP signs examined included localization, types, number of affected sides and clinical severity using the Thongprasom sign scoring system. There were significant associations (rs = 0.490, p < 0.001) between clinical severity and the intensity of oral impacts as well as pain (rs = 0.298, p = 0.013). The intensity of oral impacts and pain increased according to the increasing OLP clinical severity, except for the white striae lesions (Thongprasom sign score 1). The erosive/ulcerative OLP lesions (Thongprasom sign scores 4 and 5) were the most painful symptom and had the highest degree of oral impacts (p < 0.001). No significant associations were found between the number of affected lesion sides and OHRQoL (p = 0.316) and pain (p = 0.284). OHRQoL was associated with OLP type and clinical severity but not with the number of affected sides.

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