scholarly journals Effects of Rare Earth Elements on Blood Pressure and Their Exposure Biomarkers: Evidence from Animal Experiments

Author(s):  
Yiming Pang ◽  
Jianjun Jiang ◽  
Kexin Li ◽  
Lailai Yan ◽  
Yanqiu Feng ◽  
...  

Solid fuel combustion is an important source of the release of rare earth elements (REEs) into the ambient environment, resulting in potential adverse effects on human cardiovascular health. Our study aimed to identify reliable exposure biomarkers of REE intake and their potential role in blood pressure change. A total of 24 rats were administered with 14 REE chlorides at four doses (six rats per group). Fur samples were collected both before and after administration. Blood samples were collected after 12 weeks of REE intake. The REE concentrations in rat fur and blood samples were measured by inductively coupled plasma mass spectrometry. For each week, blood pressure, as well as heart rate and pulse pressure, were measured. The linear mixed-effect model was used to analyze the relationship between REE administration dose and blood pressure change. We found that the REE concentration in fur, but not blood, samples exhibited significant dose–response relationships with administration dose. It suggested that hair samples are a more efficient matrix for indicating the exposure level of a population to REEs than blood samples. However, there was no dose–response relationships between the administration dose and blood pressure change of rats, or with heart rate and pulse pressure for the 14 REEs. We also did not find a dose–response relationship between REE administration levels and plasma concentration of 8-hydroxy-2’-deoxyguanosine, as an important DNA oxidative stress damage biomarker. In conclusion, hair samples are more suitable as a sample type to reliably assess exposure to REEs than blood samples, and REEs did not have a direct adverse effect on blood pressure in our rat model.

1965 ◽  
Vol 43 (1) ◽  
pp. 9-18 ◽  
Author(s):  
K. I. Melville ◽  
R. A. Gillis ◽  
P. Sekelj

Changes in left circumflex coronary flow, femoral blood pressure, and heart rate (ECG-Lead II) were recorded simultaneously in pentobarbitalized artificially respired open-chest dogs. A gated sine wave electromagnetic flowmeter was used for coronary flow measurements. After intravenous nitroglycerin (glyceryl trinitrate) administration in six satisfactory experiments, changes in dose–response patterns were studied. (1) Doses of 0.1 μg/kg were ineffective; doses of 1.0, 10, and 100 μg/kg induced in 10 to 15 seconds maximal increases in mean coronary flow averaging 22, 65, and 100%, respectively; blood pressure concurrently decreased showing a maximum fall (in 20 to 25 seconds) associated with reflex tachycardia; a transient initial increase in pulse pressure also occurred. (2) Coronary flow subsequently decreased, reaching below-control values; the magnitude of this decrease appeared to be related to the degree of fall in blood pressure and to the reflex tachycardia; and pulse pressure markedly decreased below the control values. (3) After intravenous injections of pentobarbitone sodium (1 and 10 mg/kg) brief initial (within 10 seconds) dose-related increases in coronary flow were also observed but associated with less-marked blood pressure decreases and no significant changes in either heart rate or pulse pressure.


Neurology ◽  
2011 ◽  
Vol 77 (14) ◽  
pp. e84-e84 ◽  
Author(s):  
K.- J. Park ◽  
N.- C. Choi ◽  
S.- K. Kim ◽  
H. Kang ◽  
O.- Y. Kwon ◽  
...  

2000 ◽  
Vol 39 (02) ◽  
pp. 200-203
Author(s):  
H. Mizuta ◽  
K. Yana

Abstract:This paper proposes a method for decomposing heart rate fluctuations into background, respiratory and blood pressure oriented fluctuations. A signal cancellation scheme using the adaptive RLS algorithm has been introduced for canceling respiration and blood pressure oriented changes in the heart rate fluctuations. The computer simulation confirmed the validity of the proposed method. Then, heart rate fluctuations, instantaneous lung volume and blood pressure changes are simultaneously recorded from eight normal subjects aged 20-24 years. It was shown that after signal decomposition, the power spectrum of the heart rate showed a consistent monotonic 1/fa type pattern. The proposed method enables a clear interpretation of heart rate spectrum removing uncertain large individual variations due to the respiration and blood pressure change.


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