Peri-Implantitis: Application of a Protocol for the Regeneration of Deep Osseous Defects. A Retrospective Case Series

Background and aims: Peri-implantitis is a complex pathology, both in its diagnosis and in the identification of etiological causes. Although we have been studying more and more over the years to try to answer the many questions that remain regarding everything that circulates around this disease which affects implants, nothing has yet been taken as an official consensus regarding its surgical treatment. There are still many proposed protocols, each of which has been shown to have comforting results and promising prospects, but no total predictability. The aim of this case series is to assess the clinical outcomes of a mixed protocol for the regeneration of deep osseous defects. Materials and methods: The data and clinical records of 23 patients, with 29 implants affected by peri-implantitis treated surgically in private practice, were analyzed retrospectively. The method used for the surgical treatment was a mixed protocol of mechanical–chemical decontamination and bone regeneration with bovine xenograft. Results: All patients were followed for at least 2 years, averaging 28.9 months (a range of 24–38 months) with a reduction in the probing depth (PD) at one year from the initial 8.14 ± 1.156 mm to 3.72 ± 0.649 mm, and to 4.14 ± 1.093 mm at the final assessment. The differences between assessment time points were always statistically significant. The data regarding bleeding on probing (BoP) and suppuration also showed a statistically significant reduction at the final time point compared to the baseline. Only one patient, at 24 months, still showed BoP, suppuration, and a PD deeper than 5 mm, indicating a recurrence of the disease compared to the initial improvement of the PD (5 mm) at one year. Conclusions: In conclusion, within the limits of this retrospective analysis, it can be affirmed that this combined mechanical–chemical and regenerative decontamination therapy is effective in the treatment of peri-implantitis.

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Autotransplantation of mature impacted tooth to a fresh molar socket using a 3D replica and guided bone regeneration: two years retrospective case series

10.21203/rs.2.12324/v4 ◽

2019 ◽

Author(s):

Ye Wu ◽

Jiaming Chen ◽

Fuping Xie ◽

Huanhuan Liu ◽

Gang Niu ◽

...

Keyword(s):

Clinical Outcome ◽

Bone Regeneration ◽

Case Series ◽

Guided Bone Regeneration ◽

Third Molars ◽

Retrospective Case ◽

Impacted Tooth ◽

Probing Depth ◽

One Year

Abstract Background: The aim of this study was to evaluate the clinical outcome of autotransplantation of mature third molars to fresh molar extraction sockets using 3D replicas. Methods: Ten patients underwent teeth autotransplantation with or without GBR. We observed the mobility, percussion, radiography examination, the probing depth and the masticatory function of the transplanted teeth during two years following up, which were transplanted into fresh molar sockets by using 3D replicas, and GBR when it is necessary. Results: The average extra-oral time of donor tooth had been shortened to 1.65 min when used the 3D replica. Some probing depth of the transplanted tooth were deeper than 3 mm at 4 or 5 weeks temporarily. And one patient felt slight sensitive when chewing with soft food at 4 weeks, then disappeared. The clinical examination of the autotransplantation teeth during one year follow-up showed no sign of failure. Conclusions: The tooth autotransplantation using 3D replica with or without GBR is an effective method which can reduce the extra-oral time of the donor teeth and may result in less failure.

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Autotransplantation of mature impacted tooth to a fresh molar socket using a 3D replica and guided bone regeneration: two years retrospective case series

10.21203/rs.2.12324/v2 ◽

2019 ◽

Author(s):

Ye Wu ◽

Jiaming Chen ◽

Fuping Xie ◽

Huanhuan Liu ◽

Gang Niu ◽

...

Keyword(s):

Clinical Outcome ◽

Case Series ◽

Guided Bone Regeneration ◽

Third Molars ◽

Retrospective Case ◽

Impacted Tooth ◽

Probing Depth ◽

One Year ◽

It Success

Abstract Objective : The aim of this study was to evaluate the clinical outcome of autotransplantation of mature third molars to fresh molar extraction sockets using 3D replicas. Materials and Methods : Ten patients underwent teeth autotransplantation. We observed the mobility, percussion, radiography examination, the probing depth and the masticatory function of the transplanted teeth duringtwo yearsfollowing up, which were transplanted into fresh molar sockets by using 3D replicas, and GBR when it is necessary. Results : The average extra-oral time of donor tooth had been shortened to 1.65 min when used the 3D replica. Some probing depth of the transplanted tooth were deeper than 3 mm at 4 or 5 weeks temporarily. And one patient felt slight sensitive when chewing with soft food at 4 weeks, then disappeared. The clinical examination of the autotransplantation teeth during one year follow-up showed no sign of failure. Conclusions : The tooth autotransplantationusing 3D replica is an effective method which can reduce the extra-oral time of the donor teeth and may result in less failure. Clinical Relevance : The new 3D replica of donor tooth can make the surgery of tooth autotransplantation much easier, and improve it success rate.

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Autotransplantation of mature impacted tooth to a fresh molar socket using a 3D replica and guided bone regeneration: two years retrospective case series

10.21203/rs.2.12324/v3 ◽

2019 ◽

Author(s):

Ye Wu ◽

Jiaming Chen ◽

Fuping Xie ◽

Huanhuan Liu ◽

Gang Niu ◽

...

Keyword(s):

Clinical Outcome ◽

Bone Regeneration ◽

Case Series ◽

Guided Bone Regeneration ◽

Third Molars ◽

Retrospective Case ◽

Impacted Tooth ◽

Probing Depth ◽

One Year

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A review of malignant pleural mesothelioma in a large North East UK pleural centre

Pleura and Peritoneum ◽

10.1515/pp-2020-0144 ◽

2020 ◽

Vol 0 (0) ◽

Author(s):

Declan C. Murphy ◽

Alexander Mount ◽

Fiona Starkie ◽

Leah Taylor ◽

Avinash Aujayeb

Keyword(s):

Malignant Pleural Mesothelioma ◽

Survival Rates ◽

Case Series ◽

Pleural Mesothelioma ◽

Retrospective Case ◽

Pleural Thickening ◽

North East ◽

Total Cohort ◽

Anti Cancer ◽

One Year

AbstractObjectivesThe National Mesothelioma Audit 2020 showed Northumbria to have low rates of histopathological confirmation, treatment and one-year survival rates for malignant pleural mesothelioma (MPM). We hypothesized that an internal analysis over a 10-year period provides valuable insights into presentation, diagnosis, treatment and outcomes.MethodsA single-centre retrospective case series of all confirmed MPM patients between 1 January 2009 and 31 December 2019 was performed. Demographics, clinical, radiological and histopathological characteristics and outcomes were collected. Statistical analysis was performed using SPSS V26.0.ResultsA total of 247 patients had MPM. About 86% were male, mean age 75.7 years. Dyspnoea (77.4%) and chest pain (38.5%) were commonest symptoms. 64.9 and 71.4% had pleural thickening and effusion, respectively. About 86.8% had at least one attempt to obtain a tissue biopsy, but histopathological confirmation in only 108 (43.7%). About 66.3% with PS 0 and 1 (62.7% of total cohort) had at least one anti-cancer therapy. Death within 12 months was associated with disease progression within 6 months (p≤0.001). Chemotherapy (p≤0.001) and epithelioid histological subtype (p=0.01) were protective.ConclusionsThis study confirms known epidemiology of MPM, demonstrates variability in practices and highlights how some NMA recommendations are not met. This provides the incentive for a regional mesothelioma multi-disciplinary meeting.

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One-year Follow-Up Results with Hydrogel Implant in Therapy of Hallux Rigidus: Case Series with 44 Patients

Zeitschrift für Orthopädie und Unfallchirurgie ◽

10.1055/a-1365-9655 ◽

2021 ◽

Author(s):

Christoph Zanzinger ◽

Norbert Harrasser ◽

Oliver Gottschalk ◽

Patrick Dolp ◽

Florian Hinterwimmer ◽

...

Keyword(s):

Learning Algorithm ◽

Case Series ◽

Metatarsophalangeal Joint ◽

Hallux Rigidus ◽

Therapy Failure ◽

Retrospective Case ◽

Aofas Score ◽

Medium Level ◽

One Year

Abstract Background The Cartiva implant (CI) is being increasingly used in the surgical therapy of hallux rigidus. Despite a growing number of studies, numerous questions regarding patient selection remain unanswered. Patients and Methods As part of a retrospective case series with prospective follow-up (average follow-up period: 12 months), a total of 44 patients (male/female = 16/28; mean age at the time of surgery: 55.4 years) with 44 CI were analysed (VAS, EFAS-, AOFAS-score). Using a correlation analysis and a machine learning algorithm, risk factors for therapy failure were investigated. Results The overall survival rate of the CI was 93% at 12 months. The VAS, EFAS and AOFAS scores showed a significant improvement in comparison to the preoperative condition. The mobility of the metatarsophalangeal joint showed no increase. Patients with a medium osteoarthritis grade and a medium level of clinical restraint showed the greatest improvement in relation to their preoperative condition. Conclusion The CI can be seen as an effective therapy for hallux rigidus. Nonetheless, realistic patient expectations must be communicated.

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Modified Langenskiöld procedure for chronic, recurrent, and congenital patellar dislocation

Journal of Children s Orthopaedics ◽

10.1302/1863-2548.14.200044 ◽

2020 ◽

Vol 14 (4) ◽

pp. 318-329

Author(s):

Omar Ramos ◽

Corey Burke ◽

Molly Lewis ◽

Martin J. Morrison ◽

Dror Paley ◽

...

Keyword(s):

Knee Flexion ◽

Patellar Dislocation ◽

Case Series ◽

Retrospective Case ◽

Level Of Evidence ◽

Full Extension ◽

Chronic Group ◽

Patellar Maltracking ◽

Kujala Score ◽

One Year

Purpose Langenskiöld described a reconstructive soft-tissue procedure for irreducible lateral congenital patellar dislocations. Paley further detailed the technique in the surgical management of congenital femoral deficiency. The aim of this study was to evaluate the outcomes of patients with congenital, chronic and recurrent patellar dislocations treated with the modified Langenskiöld procedure. Methods This is a retrospective case series. Between 2011 and 2018, 18 knees in 13 patients (mean age 15.8 years (sd 4.4; 12 to 29.9), nine female) with diagnoses of recurrent (six patients, eight knees), chronic (four patients, six knees) and congenital (three patients, four knees) patellar dislocations were treated with the modified Langenskiöld procedure. Results There were no recurrent lateral dislocations in the congenital or recurrent groups. One of the patients in the congenital group had an overcorrection with some medial patellar maltracking but until this time has not required any further surgery. In the chronic group two of the six knees developed further dislocations; these were both on the same patient, who had no dislocations until one year after surgery. Mean Kujala score was 83.7 (sd 17; 47 to 100) for all groups. In spite of preoperative knee flexion contractures of up to 30° in three patients (six knees), all patients had full extension postoperatively. Eight patients reported being satisfied with their outcome, one was somewhat satisfied, two were very dissatisfied, and two did not respond. Conclusion The modified Langenskiöld reconstruction provides a powerful correction for challenging cases of congenital and recurrent patellar dislocations. Re-dislocation as well as overcorrection can occasionally occur. Level of Evidence Level IV

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One‐year results of a nonsurgical treatment protocol for peri‐implantitis. A retrospective case series

Clinical Oral Implants Research ◽

10.1111/clr.13456 ◽

2019 ◽

Vol 30 (7) ◽

pp. 702-712 ◽

Cited By ~ 6

Author(s):

Ruth Estefanía‐Fresco ◽

Ana M. García‐de‐la‐Fuente ◽

Aitor Egaña‐Fernández‐Valderrama ◽

Manuel Bravo ◽

Luis Antonio Aguirre‐Zorzano

Keyword(s):

Treatment Protocol ◽

Case Series ◽

Nonsurgical Treatment ◽

Retrospective Case ◽

Retrospective Case Series ◽

One Year

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P0258EVALUATION OF ACUTE - PHASE REACTANTS IN MONITORING DISEASE ACTIVITY AND RESPONSE TO IMMUNOSUPPRESSIVE THERAPY IN IDIOPATHIC RETROPERITONEAL FIBROSIS

Nephrology Dialysis Transplantation ◽

10.1093/ndt/gfaa142.p0258 ◽

2020 ◽

Vol 35 (Supplement_3) ◽

Author(s):

Katarina Obrencevic ◽

Marijana Petroviä‡ ◽

Nemanja Rancic ◽

Jelena Tadiä‡ ◽

Neven Vavic ◽

...

Keyword(s):

Retroperitoneal Fibrosis ◽

Case Series ◽

Immunosuppressive Drugs ◽

Obstructive Nephropathy ◽

Mass Reduction ◽

Retrospective Case ◽

Idiopathic Retroperitoneal Fibrosis ◽

Acute Phase Reactants ◽

Case Series Study ◽

One Year

Abstract Background and Aims Idiopathic retroperitoneal fibrosis (IRF) is a rare disease characterized by fibroinflammatory periaortic tissue that affects the ureters, causing obstructive nephropathy and impairment of renal function. Findings strongly suggest an autoimmune etiology. Medical treatment includes immunosuppressive drugs, but the optimal treatment has not been established. Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) represent markers of active inflammation in the early phase of the disease, and hence could be sensitive predictors of the treatment response. Method This retrospective case series study includes patients with IRF treated with two different protocols: corticosteroids in combination with mycophenolate mofetil (MMF) and corticosteroids combined with azathioprine (AZA). The total number of 28 patients (13 in the first group and 15 in the second group) were treated and followed in the Clinic of nephrology in Military Medical Academy. Results At presentation 92.3% of patients had elevated levels of ESR and CRP, and 67.8% of them had acute renal insufficiency. Systemic symptoms resolved after four weeks in all patients. The kidney function improved significantly in both groups after first moth of treatment, although the creatinine level was higher in the MMF group because of the disease recurrence in 23% of the patients. In MMF group was observed faster reduction in the periaortic mass after six months and 53.8% of patients achieve 100% of the mass reduction at the end of the treatment while 33.3% in AZA group. The levels of ESR and CRP after one month of treatment in AZA group correlated with the fibrotic mass reduction after six months and after one year. In MMF group, only the CRP level after one month correlated with the fibrotic mass reduction achieved after one year. Conclusion MMF had more rapid and complete effect in hydrnephrosis withdrawal and total reduction of the fibrotic tissue, comparing with AZA whose effect was slower and without complete mass reduction. CRP strongly correlated with the remission of the disease in both therapeutic protocols.

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Evaluation of Metatarsal Head Resurfacing Hemiarthroplasty in the Surgical Treatment of Hallux Rigidus: A Retrospective Study and Mid- to Long-Term Follow-up

Foot & Ankle Specialist ◽

10.1177/1938640017695864 ◽

2017 ◽

Vol 11 (1) ◽

pp. 22-31 ◽

Cited By ~ 1

Author(s):

Musa Uğur Mermerkaya ◽

Erkan Alkan ◽

Mehmet Ayvaz

Keyword(s):

Surgical Treatment ◽

Case Series ◽

Metatarsophalangeal Joint ◽

Metatarsal Head ◽

Treatment Method ◽

Hallux Rigidus ◽

Retrospective Case ◽

First Metatarsophalangeal Joint

Background. The aim of this study was to evaluate the mid- to long-term outcomes of metatarsal head resurfacing hemiarthroplasty in the surgical treatment of advanced-stage hallux rigidus. Methods. We performed a retrospective review of 57 consecutive patients (25 [43.9%] males, 32 [56.1%] females; mean age, 61.0 ± 6.4 years) who underwent first metatarsal head resurfacing hemiarthroplasty (HemiCAP) for hallux rigidus between August 2007 and September 2010. Sixty-five implantations were performed in 57 patients; 8 patients underwent bilateral procedures. All patients were clinically rated prior to surgery and at the final follow-up visit using the American Orthopaedic Foot and Ankle Society (AOFAS) hallux metatarsophalangeal-interphalangeal scale and first metatarsophalangeal joint range of motion (MTPJ ROM). Results. The median follow-up duration was 81 (range = 8-98) months. The median preoperative AOFAS score was 34 (range = 22-59) points, which had increased to 83 (range = 26-97) points at the final follow-up visit (P < .001). The median preoperative first MTPJ ROM was 25° (range = 15° to 40°), which had increased to 75° (range = 30° to 85°) at the final follow-up visit (P < .001). Conclusions. First MTPJ hemiarthroplasty is an effective treatment method that recovers toe function and first MTPJ ROM, and provides good mid- to long-term functional outcomes. Levels of Evidence: Level IV: Retrospective case series

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Accelerated Corneal Collagen Cross-Linking Using Topography-Guided UV-A Energy Emission: Preliminary Clinical and Morphological Outcomes

Journal of Ophthalmology ◽

10.1155/2016/2031031 ◽

2016 ◽

Vol 2016 ◽

pp. 1-10 ◽

Cited By ~ 14

Author(s):

Cosimo Mazzotta ◽

Antonio Moramarco ◽

Claudio Traversi ◽

Stefano Baiocchi ◽

Alfonso Iovieno ◽

...

Keyword(s):

Anterior Segment ◽

Case Series ◽

Cross Linking ◽

Optic Coherence Tomography ◽

Retrospective Case ◽

One Year ◽

Coma Aberration ◽

Topographic Astigmatism ◽

Corneal Collagen

Purpose. To assess the clinical and morphological outcomes of topography-guided accelerated corneal cross-linking. Design. Retrospective case series. Methods. 21 eyes of 20 patients with progressive keratoconus were enrolled. All patients underwent accelerated cross-linking using an ultraviolet-A (UVA) exposure with an energy release varying from 7.2 J/cm2 up to 15 J/cm2, according to the topographic corneal curvature. Uncorrected (UDVA) and corrected (CDVA) distance visual acuity, topography, in vivo confocal microscopy (IVCM), and anterior segment optic coherence tomography (AS-OCT) were evaluated preoperatively and at the 1, 3, 6, and 12 months postoperatively. Results. 12 months after surgery UDVA and CDVA did not significantly vary from preoperative values. The average topographic astigmatism decreased from -4.61±0.74 diopters (D) to -3.20±0.81 D and coma aberration improved from 0.95 ± 0.03 μm to 0.88 ± 0.04 μm after surgery. AS-OCT and IVCM documented differential effects on the treated areas using different energies doses. The depths of demarcation line and keratocyte apoptosis were assessed. Conclusions. Preliminary results show correspondence between the energy dose applied and the microstructural stromal changes induced by the cross-linking at various depths in different areas of treated cornea. One year after surgery a significant reduction in the topographic astigmatism and comatic aberration was detected. None of the patients developed significant complications.

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