scholarly journals Carotid Artery Plaque Progression: Proposal of a New Predictive Score and Role of Carotid Intima-Media Thickness

2022 ◽  
Vol 19 (2) ◽  
pp. 758
Author(s):  
Nicoletta Brunelli ◽  
Claudia Altamura ◽  
Carmelina Maria Costa ◽  
Riccardo Altavilla ◽  
Paola Palazzo ◽  
...  
Keyword(s):  
Real Life ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Predictive Score ◽  
Plaque Progression ◽  
Carotid Artery Plaque ◽  
Plaque Score ◽  
Media Thickness

Background: We aimed to investigate if the carotid intima-media thickness (IMT) at baseline and the HAD2S score, composed of the sum of single risk factors (hypertension, age ≥ 75 years, diabetes, dyslipidemia, smoking), were predictive of plaque progression. Methods: We performed a retrospective analysis on real-life prospectively collected data from patients with any detectable carotid plaque at follow up. The plaque score, calculated at baseline (T0) and at a median follow up of 36.6 months (IQR 39.6–34.3) (T3), was defined as 0: no plaque or stenosis < 30%; 1: stenosis in the range 30–49%; 2: in the range 50–69%; 3: in the range 70–99% and 4: occlusion. Carotid IMT was measured at T0 and T3; HAD2S score was calculated at baseline. Results: We included 340 patients with a mean age of 69.9 (9.1) years and 25.3% subjects had plaque progression. Individuals with progression had a median HAD2S score of 3 (1) while those without progression had 2 (1). Patients with progression had a mean baseline IMT of 0.86 (0.17) while those without progression had 0.77 (0.18) (p < 0.0001). A correlation between progression and baseline IMT was found (p = 0.002). Conclusion: Baseline IMT could be considered a predictor of progression. Patients with progression had an HAD2S score higher than those without evolution.

Carotid artery plaque progression: Proposal of a new predictive score and role of carotid intima-media thickness

2021 ◽  
Vol 429 ◽  
pp. 117656
Author(s):  
Nicoletta Brunelli ◽  
Claudia Altamura ◽  
Carlemina Maria Costa ◽  
Riccardo Altavilla ◽  
Paola Palazzo ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Predictive Score ◽  
Plaque Progression ◽  
Carotid Artery Plaque ◽  
Media Thickness

P1535Clinical impact of carotid plaque score rather than carotid intima-media thickness on atherosclerotic cardiovascular disease

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
H Tada ◽  
T Nakagawa ◽  
H Okada ◽  
T Nakahashi ◽  
M Mori ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Disease ◽  
Carotid Plaque ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Plaque Burden ◽  
Atherosclerotic Cardiovascular Disease ◽  
Plaque Score ◽  
Media Thickness

Abstract Background Carotid intima-media thickness (cIMT) assessed by ultrasound has been widely accepted as a surrogate marker of atherosclerotic cardiovascular disease. On the other hand, carotid plaque score (cPS) reflecting throughout the carotid artery plaque burden may be better marker. Methods We retrospectively examined 2,035 patients who underwent carotid ultrasonography between January 2006 and December 2015 at our University Hospital. Median follow-up period was 4 years. We used Cox models that adjusted for established risk factors of ASCVD, including age, gender, hypertension, diabetes, smoking, and serum lipids to assess the association of cIMT as well as cPS with major adverse cardiac events (MACE). MACE was defined as all-cause mortality or rehospitalization for a cardiovascular-related illness Results During follow-up, 243 participants experienced MACE. After adjustment for established risk factors, cPS was associated with MACE (hazard ratio [HR] = 3.38 for top quintile vs. bottom quintile of cPS; 95% confidence interval [CI] 1.82 to 6.27; P-trend = 1.4×10–8), while cIMT was not (HR = 0.88, P=0.57). Addition of the cPS to established risk factors significantly improved risk discrimination (C-index 0.726 vs. 0.746; P=0.017) Conclusion As a marker, cPS, rather than cIMT can identify 20% of individuals who are at more than three-fold increased risk for MACE. Targeting diagnostic or therapeutic interventions to this subset may prove clinically useful.

scholarly journals Risk factors for changes in carotid intima media thickness and plaque over 5 years in women with systemic lupus erythematosus

2021 ◽  
Vol 8 (1) ◽  
pp. e000548
Author(s):  
Apinya Lertratanakul ◽  
Julia Sun ◽  
Peggy W Wu ◽  
Jungwha Lee ◽  
Alan Dyer ◽  
...  
Keyword(s):  
Risk Factors ◽  
Waist Circumference ◽  
Lupus Erythematosus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Plaque Progression ◽  
Carotid Imt ◽  
Media Thickness ◽  
The Mean

ObjectiveTo investigate the occurrence of and risk factors for progression of carotid intima media thickness (IMT) and plaque in women with and without SLE.MethodsA cohort of 149 women with SLE and 126 controls participated in SOLVABLE (Study of Lupus Vascular and Bone Long-term Endpoints). Demographics, cardiovascular and SLE factors, and laboratory assessments were collected at baseline. Carotid IMT and plaque were measured using B-mode ultrasound at baseline and at 5-year follow-up. Regression models were used to identify predictors of progression in carotid IMT and plaque; multivariate models were adjusted for age, hypertension and total cholesterol to high-density lipoprotein ratio.ResultsThe mean±SD follow-up time was 5.35±0.60 years in cases and 5.62±0.66 years in controls. The mean IMT change per year was 0.008±0.015 mm in cases and 0.005±0.019 mm in controls (p=0.24). At follow-up, 31.5% of cases and 15% of controls had plaque progression, with a relative risk for plaque progression of 2.09 (95% CI 1.30 to 3.37). In SLE cases, higher fasting glucose and lower fibrinogen were associated with IMT progression after adjustment. Larger waist circumference and non-use of hydroxychloroquine were associated with plaque progression after adjustment.ConclusionPotential modifiable risk factors for carotid IMT and plaque progression in women with SLE were identified, suggesting that monitoring of glucose and waist circumference and use of hydroxychloroquine may be beneficial.

Carotid intima-media thickness and bone turnover: the role of C-terminal telopeptide of type I collagen

2010 ◽  
Vol 5 (2) ◽  
pp. 127-134 ◽  
Author(s):  
Christian Leli ◽  
Leonella Pasqualini ◽  
Gaetano Vaudo ◽  
Stefano Gaggioli ◽  
Anna Maria Scarponi ◽  
...  
Keyword(s):  
Bone Turnover ◽  
Type I Collagen ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Type I ◽  
Media Thickness

Common Carotid Intima-media Thickness in Patients with Late Rheumatoid Arthritis; What Is the Role of Gender?

2011 ◽  
Vol 14 (16) ◽  
pp. 812-816 ◽  
Author(s):  
Abolhassan Shakeri ◽  
Mohammad Babaei Bazzaz ◽  
Alireza Khabbazi ◽  
Rohollah Fadaei Fouladi
Keyword(s):  
Rheumatoid Arthritis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Media Thickness

scholarly journals Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China

BMJ Open ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. e030721
Author(s):  
Haiyu Pang ◽  
Yicong Ye ◽  
Faming Ding ◽  
Mengtao Li ◽  
Xinglin Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systemic Lupus Erythematosus ◽  
Informed Consent ◽  
Lupus Erythematosus ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Systemic Lupus ◽  
Media Thickness ◽  
Artery Disease

IntroductionAccelerated atherosclerosis is a major complication of systemic lupus erythematosus (SLE), and it leads to increased cardiovascular morbidity and mortality in patients with SLE. This study aimed to investigate the natural progression of carotid intima-media thickness (CIMT), and to examine the risk factors for progression of CIMT and atherosclerotic plaques based on a Chinese SLE cohort.Methods and analysisParticipants were continuously enrolled as outpatients of the Department of Rheumatology in Peking Union Medical College Hospital (PUMCH) from October 2013 to December 2016. Inclusion criteria were as follows: (1) age ≥18 years, (2) fulfilment of clinical classification criteria of SLE and (3) provision of signed written informed consent. Patients with clinically overt coronary artery disease, a history of cardiovascular disease (previous stroke, heart failure, myocardial infarction, angina or symptomatic peripheral artery disease) and malignancy, and pregnant/lactating women were excluded. The primary outcome is progression of CIMT from baseline. A total of 440 patients with SLE will be enrolled. Participants will receive follow-up surveys ~5 years after their baseline visit. A standard structural survey form, including demographic data, medical history, clinical and laboratory assessments and CIMT measurement, is planned for data collection at baseline and follow-up. The risk prediction model for progression of CIMT will be created by using a mixed effect model.Ethics and disseminationThe study protocol was approved by the institutional review board of PUMCH (S-599). Informed consent was obtained from all participants according to the Declaration of Helsinki on Biomedical Research Involving Human Studies. All data will be managed confidentially according to guidelines and legislation. Dissemination will include publication of scientific papers and/or presentations of the study findings at international conferences.

scholarly journals The association between carotid intima-media thickness and new-onset hypertension in a Chinese community-based population

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Long Zhang ◽  
Fangfang Fan ◽  
Litong Qi ◽  
Jia Jia ◽  
Ying Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Strong Association ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Incidence Rates ◽  
Community Based ◽  
Media Thickness ◽  
The Mean ◽  
New Onset

Abstract Background Hypertension and arterial vasculopathy may be mutual causes and effects. It is unknown whether carotid intima-media thickness (cIMT) is reliably predictive of the presence of newly developed hypertension in the Chinese population. This study evaluated the impacts of cIMT on new-onset hypertension in a community-based population without hypertension at baseline in China. Methods A total of 672 Chinese subjects who had complete data for demographics, baseline and follow-up blood pressure measurements, and cIMT measurements at baseline were included in our study. Baseline cIMT was obtained under standardized procedures using the GE Vivid 7 ultrasound system equipped with an 8-MHz linear array vascular probe (GE Medical Systems, Milwaukee, Wl, USA). The outcome was the incidence of hypertension at follow-up. Multivariate regression models were used to access the association between baseline cIMT and the risk of new-onset hypertension. Results Subjects were 51.5 ± 4.7 years old, and 32.0% were male. The mean baseline systolic blood pressure (SBP) was 122.5 ± 10.0 mmHg. The mean baseline diastolic blood pressure (DBP) was 72.4 ± 7.5 mmHg. The number of subjects with thickened cIMT (maximum ≥0.9 mm) at baseline was 198 (29.5%). After 2.3 years of follow-up, the rate of new-onset hypertension was 12.6%. The incidence rates of hypertension in the groups with thickened cIMT and normal cIMT were 19.2 and 9.9%, respectively. In the multivariable logistic regression analyses, both the average (OR = 1.69, 95% CI: 1.30–2.19, P = 0.0001) and maximum (OR = 1.55, 95% CI: 1.23–1.95, P = 0.0002) cIMT were significantly associated with new-onset hypertension after adjustment for various confounders. The group with thickened cIMT showed a higher risk for the incidence of hypertension, with an OR of 1.82 (95% CI: 1.07–3.10, P = 0.0270), compared to the normal group. Conclusion Thickened cIMT has a strong association with incident hypertension risk in a community-based population without hypertension at baseline in China.

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