scholarly journals Photoirradiation of Polycyclic Aromatic Hydrocarbons with UVA Light – A Pathway Leading to the Generation of Reactive Oxygen Species, Lipid Peroxidation, and DNA Damage

2006 ◽  
Vol 3 (4) ◽  
pp. 348-354 ◽  
Author(s):  
Hongtao Yu ◽  
Qingsu Xia ◽  
Jian Yan ◽  
Diogenes Herreno-Saenz ◽  
Yuh-Shen Wu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Lipid Peroxidation ◽  
Dna Damage ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Uva Light ◽  
Polycyclic Aromatic

scholarly journals Genotoxicity of ortho-quinones: reactive oxygen species versus covalent modification

2017 ◽  
Vol 6 (6) ◽  
pp. 740-754 ◽  
Author(s):  
Trevor M. Penning
Keyword(s):  
Reactive Oxygen Species ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Aromatic Hydrocarbons ◽  
Reactive Oxygen ◽  
Covalent Modification ◽  
Oxygen Species ◽  
Polycyclic Aromatic ◽  
Synthetic Estrogens ◽  
Natural And Synthetic

o-Quinones are formed metabolically from natural and synthetic estrogens as well as upon exposure to polycyclic aromatic hydrocarbons (PAH) and contribute to estrogen and PAH carcinogenesis by genotoxic mechanisms.

Photoirradiation of representative polycyclic aromatic hydrocarbons and twelve isomeric methylbenz[a]anthracene with UVA light: formation of lipid peroxidation

2006 ◽  
Vol 22 (4) ◽  
pp. 147-156 ◽  
Author(s):  
Qingsu Xia ◽  
Ming W Chou ◽  
Jun J Yin ◽  
Paul C Howard ◽  
Hongtao Yu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Polycyclic Aromatic Hydrocarbons ◽  
Free Radical ◽  
Methyl Linoleate ◽  
Aromatic Hydrocarbons ◽  
Lipid Peroxide ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Uva Light ◽  
Polycyclic Aromatic

Polycyclic aromatic hydrocarbons (PAHs) are widespread genotoxic environmental pollutants, which require metabolic activation in order to exert biological activities, including mutagenicity and carcinogenicity. Photoactivation is another activation pathway that can lead to PAH genotoxicity. In this paper, we demonstrate that photoirradiation of a series of representative PAHs, with and without bearing a methyl substituent, with UVA light in the presence of methyl linoleate resulted in the formation of methyl linoleate hydroperoxides (a lipid peroxide). The lipid peroxide formation was inhibited by dithiothreitol (DTT) (free radical scavenger), NaN3 (singlet oxygen and free radical scavenger), and superoxide dismutase (SOD) (superoxide scavenger), but was enhanced by the presence of deuterium oxide (D2O) (extends singlet oxygen lifetime). These results suggest that photoirradiation of PAHs by UVA light generates reactive oxygen species (ROS), which induce lipid peroxidation.

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