scholarly journals Translocator Protein-18 kDa (TSPO) Positron Emission Tomography (PET) Imaging and Its Clinical Impact in Neurodegenerative Diseases

2017 ◽  
Vol 18 (4) ◽  
pp. 785 ◽  
Author(s):  
Anne-Claire Dupont ◽  
Bérenger Largeau ◽  
Maria Santiago Ribeiro ◽  
Denis Guilloteau ◽  
Claire Tronel ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Neurodegenerative Diseases ◽  
Pet Imaging ◽  
Clinical Impact ◽  
Translocator Protein ◽  
Emission Tomography ◽  
Positron Emission ◽  
Translocator Protein 18 Kda

Positron emission tomography imaging in evaluation of MS pathology in vivo

2018 ◽  
Vol 24 (11) ◽  
pp. 1399-1412 ◽  
Author(s):  
Heidi Högel ◽  
Eero Rissanen ◽  
Anna Vuorimaa ◽  
Laura Airas
Keyword(s):  
Positron Emission Tomography ◽  
Pet Imaging ◽  
Human Subjects ◽  
Positron Emission Tomography Imaging ◽  
Translocator Protein ◽  
Emission Tomography ◽  
Amyloid Pet ◽  
Positron Emission ◽  
Density Evaluation

Positron emission tomography (PET) gives an opportunity to quantitate the expression of specific molecular targets in vivo and longitudinally in brain and thus enhances our possibilities to understand and follow up multiple sclerosis (MS)-related pathology. For successful PET imaging, one needs a relevant target molecule within the brain, to which a blood–brain barrier–penetrating specific radioligand will bind. 18-kDa translocator protein (TSPO)-binding radioligands have been used to detect activated microglial cells at different stages of MS, and remyelination has been measured using amyloid PET. Several PET ligands for the detection of other inflammatory targets, besides TSPO, have been developed but not yet been used for imaging MS patients. Finally, synaptic density evaluation has been successfully tested in human subjects and gives opportunities for the evaluation of the development of cortical and deep gray matter pathology in MS. This review will discuss PET imaging modalities relevant for MS today.

[18F]FPBMP: – a potential new positron emission tomography radioligand for imaging of translocator protein (18 kDa) in peripheral organs of rats

RSC Advances ◽  
2015 ◽  
Vol 5 (123) ◽  
pp. 101447-101454 ◽  
Author(s):  
Anjani K. Tiwari ◽  
Joji Yui ◽  
Yiding Zhang ◽  
Masayuki Fujinaga ◽  
Tomoteru Yamasaki ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Translocator Protein ◽  
Emission Tomography ◽  
Peripheral Tissues ◽  
Activated Microglia ◽  
Peripheral Organs ◽  
Positron Emission ◽  
Translocator Protein 18 Kda ◽  
Lung And Kidney

The five transmembrane translocator protein (18 kDa, TSPO) is abundantly expressed in the mitochondria of activated microglia (brain) and peripheral tissues, including those of the heart, lung and kidney.

Synthesis of two novel [18F]fluorobenzene-containing radiotracers via spirocyclic iodonium ylides and positron emission tomography imaging of translocator protein (18 kDa) in ischemic brain

2018 ◽  
Vol 16 (37) ◽  
pp. 8325-8335 ◽  
Author(s):  
Masayuki Fujinaga ◽  
Katsushi Kumata ◽  
Yiding Zhang ◽  
Akiko Hatori ◽  
Tomoteru Yamasaki ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Positron Emission Tomography Imaging ◽  
Translocator Protein ◽  
Emission Tomography ◽  
Ischemic Brain ◽  
Tomography Imaging ◽  
Positron Emission ◽  
Translocator Protein 18 Kda ◽  
Iodonium Ylides ◽  
The Brain

A new radiotracer for imaging TSPO: Ki, 0.70 nM and no radiolabeled metabolite in the brain.

Sign in / Sign up

Export Citation Format

Share Document