scholarly journals Sex Hormone Receptor Signals in Human Malignancies

2019 ◽  
Vol 20 (11) ◽  
pp. 2677
Author(s):  
Hiroshi Miyamoto
Keyword(s):  
Transcription Factors ◽  
Nuclear Receptor ◽  
Reproductive System ◽  
Sex Steroids ◽  
Hormone Receptor ◽  
Hormone Receptors ◽  
Sex Hormone ◽  
Nuclear Receptor Superfamily ◽  
Sex Hormone Receptor

Sex steroids, including androgens, estrogens, and progestogens, are known to have widespread physiological actions beyond the reproductive system via binding to the sex hormone receptors, members of the nuclear receptor superfamily that function as ligand-inducible transcription factors [...]

scholarly journals Structure and Function of the Nuclear Receptor Superfamily and Current Targeted Therapies of Prostate Cancer

Cancers ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 1852 ◽  
Author(s):  
Baylee A. Porter ◽  
Maria A. Ortiz ◽  
Gennady Bratslavsky ◽  
Leszek Kotula
Keyword(s):  
Prostate Cancer ◽  
Transcription Factors ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Cell Permeability ◽  
Cancer Therapies ◽  
Functional Difference ◽  
Nuclear Receptor Superfamily ◽  
Functional Regulation ◽  
And Function

The nuclear receptor superfamily comprises a large group of proteins with functions essential for cell signaling, survival, and proliferation. There are multiple distinctions between nuclear superfamily classes defined by hallmark differences in function, ligand binding, tissue specificity, and DNA binding. In this review, we utilize the initial classification system, which defines subfamilies based on structure and functional difference. The defining feature of the nuclear receptor superfamily is that these proteins function as transcription factors. The loss of transcriptional regulation or gain of functioning of these receptors is a hallmark in numerous diseases. For example, in prostate cancer, the androgen receptor is a primary target for current prostate cancer therapies. Targeted cancer therapies for nuclear hormone receptors have been more feasible to develop than others due to the ligand availability and cell permeability of hormones. To better target these receptors, it is critical to understand their structural and functional regulation. Given that late-stage cancers often develop hormone insensitivity, we will explore the strengths and pitfalls of targeting other transcription factors outside of the nuclear receptor superfamily such as the signal transducer and activator of transcription (STAT).

scholarly journals Structure and Function of the Nuclear Receptor Superfamily and Current Targeted Therapies of Prostate Cancer

2019 ◽  
Author(s):  
Baylee Porter ◽  
Maria A. Ortiz ◽  
Gennady Bratslavsky ◽  
Leszek Kotula
Keyword(s):  
Prostate Cancer ◽  
Transcription Factors ◽  
Nuclear Receptor ◽  
Hormone Receptors ◽  
Cell Permeability ◽  
Cancer Therapies ◽  
Functional Difference ◽  
Nuclear Receptor Superfamily ◽  
Functional Regulation ◽  
And Function

The nuclear receptor superfamily comprises a large group of proteins with functions essential for cell signaling, survival and proliferation. There are multiple distinctions between nuclear superfamily classes defined by hallmark differences in function, ligand binding, tissue specificity, and DNA binding. In this review, we utilize the initial classification system, which defines subfamilies based on structure and functional difference. The defining feature of the nuclear receptor superfamily is that these proteins function as transcription factors. The loss of transcriptional regulation or gain of functioning of these receptors is a hallmark in numerous diseases. For example, in prostate cancer the androgen receptor is a primary target for current prostate cancer therapies. Targeted cancer therapies for nuclear hormone receptors have been more feasible than others to develop due to ligand availability and cell permeability of hormones. To better target these receptors, it is critical to understand their structural and functional regulation. Given that late-stage cancers often develop hormone insensitivity, we will explore the strengths and pitfalls of targeting other transcription factors outside of the nuclear receptor superfamily such as the signal transducer and activator of transcription (STAT).

The evolution of the nuclear receptor superfamily

2004 ◽  
Vol 40 ◽  
pp. 11-26 ◽  
Author(s):  
Héctor Escriva ◽  
Stéphanie Bertrand ◽  
Vincent Laudet
Keyword(s):  
Transcription Factors ◽  
Nuclear Receptors ◽  
Nuclear Receptor ◽  
Evolutionary History ◽  
Hormone Receptors ◽  
Nuclear Receptor Superfamily ◽  
Complete Genomes ◽  
High Degree ◽  
Animal Genomes

Nuclear receptors form a superfamily of ligand-activated transcription factors implicated in various physiological functions from development to homoeostasis. Nuclear receptors share a common evolutionary history revealed by their conserved structure and by their high degree of sequence conservation. Here we review the latest advances on the evolution of nuclear receptors by addressing the following questions. What is known about the appearance and diversification of nuclear hormone receptors? How did their different functional characteristics evolve? What can we infer from the analysis of complete genomes? In summary, the study of the evolution of nuclear receptors will be very important not only for understanding their functions in vivo but also for obtaining insights into the evolution of animal genomes as a whole.

Sex Hormone Receptor Expression in the Human Vocal Fold Subunits

2017 ◽  
Vol 31 (4) ◽  
pp. 476-482 ◽  
Author(s):  
Tolga Kirgezen ◽  
Ahmet Volkan Sunter ◽  
Ozgur Yigit ◽  
Gulben Erdem Huq
Keyword(s):  
Hormone Receptor ◽  
Vocal Fold ◽  
Sex Hormone ◽  
Receptor Expression ◽  
Sex Hormone Receptor ◽  
Hormone Receptor Expression

Sex hormone receptor levels in laryngeal carcinoma: a comparison between protein and RNA evaluations

2008 ◽  
Vol 265 (9) ◽  
pp. 1089-1094 ◽  
Author(s):  
Chiara Bianchini ◽  
Antonio Pastore ◽  
Stefano Pelucchi ◽  
Elena Torreggiani ◽  
Elisabetta Lambertini ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Laryngeal Carcinoma ◽  
Sex Hormone ◽  
Sex Hormone Receptor

scholarly journals Minireview: Nuclear Receptor-Controlled Steroid Hormone Synthesis and Metabolism

2010 ◽  
Vol 24 (1) ◽  
pp. 11-21 ◽  
Author(s):  
Jinhan He ◽  
Qiuqiong Cheng ◽  
Wen Xie
Keyword(s):  
Transcription Factors ◽  
Dna Binding ◽  
Steroid Hormones ◽  
Nuclear Receptor ◽  
Recent Progress ◽  
Hormone Receptors ◽  
Steroid Hormone ◽  
Etiological Factor ◽  
Hormone Synthesis

Abstract Steroid hormones are essential in normal physiology whereas disruptions in hormonal homeostasis represent an important etiological factor for many human diseases. Steroid hormones exert most of their functions through the binding and activation of nuclear hormone receptors (NRs or NHRs), a superfamily of DNA-binding and often ligand-dependent transcription factors. In recent years, accumulating evidence has suggested that NRs can also regulate the biosynthesis and metabolism of steroid hormones. This review will focus on the recent progress in our understanding of the regulatory role of NRs in hormonal homeostasis and the implications of this regulation in physiology and diseases.

Sign in / Sign up

Export Citation Format

Share Document