Dry Eye Disease and Tear Cytokine Levels—A Meta-Analysis

Background—It is recognized that inflammation is an underlying cause of dry eye disease (DED), with cytokine release involved. We systematically reviewed literature with meta-analyses to quantitatively summarize the levels of tear cytokines in DED. Methods—The PubMed, Embase, Web of Science, Ovid, Cochrane, and Scopus databases were reviewed until September 2019, and original articles investigating tear cytokines in DED patients were included. Differences of cytokines levels of DED patients and controls were summarized by standardized mean differences (SMD) using a random effects model. Study quality was assessed by applying Newcastle-Ottawa-Scale and the GRADE quality score. Methods of analytical procedures were included as covariate. Results—Thirteen articles investigating 342 DED patients and 205 healthy controls were included in the meta-analysis. The overall methodological quality of these studies was moderate. Systematic review of the selected articles revealed that DED patients had higher tear levels of interleukin (IL)-1β, IL-6, chemokine IL-8, IL-10, interferon-γ, IFN-γ, and tumor necrosis factor-α, TNF-α as compared to controls. Evidence was less strong for IL-2 and IL-17A. Conclusions—Data show that levels of tear cytokines in DED and control display a great variability, and further studies of higher quality enrolling a higher number of subjects are needed, to define a cut-off value.

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A bibliometric analysis of systematic review/meta-analysis on dry eye disease

10.21203/rs.2.19572/v1 ◽

2019 ◽

Author(s):

Yonggang Zhang ◽

An Ping ◽

Shuyuan Lyu

Keyword(s):

Systematic Review ◽

Dry Eye ◽

Systematic Reviews ◽

Core Collection ◽

Meta Analysis ◽

Dry Eye Disease ◽

Eye Disease ◽

Evidence Based ◽

Meta Analyses ◽

Number Of Citations

Abstract Background There was no citation analysis about systematic review/meta-analysis published on dry eye disease (DED). The objective of this study was to identify the citations of systematic review/meta-analysis published on DED and to provide information on the achievement and development of evidence-based dry eye research.Methods Web of Knowledge Core Collection was searched for all systematic review/meta-analysis relevant to DED. The number of citations, authorship, year, journal, country, and institution were analyzed for each study.Results A total of 29 systematic reviews/meta-analyses on DED published between 2009 and 2017 were included. The number of citations ranged from 0 to 63, with a medium of 8 citations. These systematic reviews/meta-analyses were from 10 countries, and 15 of them were from China. They were published in 21 journals. Ocular Surface published most studies (n =4), followed by International Journal of Ophthalmology (n =3). The journal with highest impact factor was Nutrition Reviews (IF=5.291 in 2016).Conclusion The citations of systematic reviews/meta-analyses on DED are still low. Further systematic reviews/meta-analyses are needed for providing more evidence for DED.

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Dry eye disease and psychiatric disorders: A systematic review and meta-analysis

European Journal of Ophthalmology ◽

10.1177/11206721211060963 ◽

2021 ◽

pp. 112067212110609

Author(s):

Amy Basilious ◽

Cathy Y Xu ◽

Monali S Malvankar-Mehta

Keyword(s):

Dry Eye ◽

Meta Analysis ◽

Depression Scale ◽

Signs And Symptoms ◽

Dry Eye Disease ◽

Eye Disease ◽

Depression And Anxiety ◽

Random Effects Models ◽

Newcastle Ottawa Scale ◽

Eye Symptoms

The association between dry eye disease (DED) and psychiatric conditions is a highly researched topic. This work reviews the literature on this relationship, examining the prevalence and correlations of depression and anxiety with dry eye signs and symptoms. A comprehensive literature search of MEDLINE, EMBASE, PsycINFO, and gray literature was conducted, with keywords for dry eye and mood disorders, depression, anxiety, and suicide. Eligible studies underwent quality assessment using the Newcastle-Ottawa Scale. Meta-analysis was performed using STATA 15.0. Fixed- and random-effects models were computed based on the presence of heterogeneity. Thirty-two studies were included, with 31 reporting on depression and 19 on anxiety. Meta-analysis results found a depression prevalence of 40% (CI: [0.29, 0.52]) in DED patients, with 1.81 times higher odds of prevalence compared to controls (CI: [1.61, 2.02]). Prevalence of anxiety was 39% (CI: [0.15, 0.64]), with 2.32 times higher odds of prevalence compared to controls (CI: [1.67, 3.23]). Depression scores were significantly higher in patients with DED in all studies. Anxiety scores were significantly higher in DED patients in studies using all scales except the Hospital Anxiety and Depression Scale-Anxiety Subscale. DED symptom scores were significantly associated with depression (ES = 0.43; CI: [0.31, 0.55]) and anxiety (ES = 0.41; CI: [0.32, 0.50]) scores. In conclusion, depression and anxiety are more prevalent and severe in DED patients and are correlated with dry eye symptoms but not signs. These findings highlight the interrelationship between these disorders and have important implications for providing appropriate care to these patients.

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Oxidative and antioxidative stress markers in dry eye disease: A systematic review and meta‐analysis

Acta Ophthalmologica ◽

10.1111/aos.14892 ◽

2021 ◽

Author(s):

Valentin Navel ◽

Vincent Sapin ◽

Fanny Henrioux ◽

Loïc Blanchon ◽

Antoine Labbé ◽

...

Keyword(s):

Systematic Review ◽

Dry Eye ◽

Meta Analysis ◽

Dry Eye Disease ◽

Eye Disease ◽

Stress Markers ◽

Antioxidative Stress

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An Association Rule Analysis of Combined Acupoints for the Treatment of Patients with Dry Eye Disease

Complementary Medicine Research ◽

10.1159/000512674 ◽

2020 ◽

pp. 1-8

Author(s):

Ya-Hsuan Lin ◽

Hsein-Chang Wu ◽

Po-Chun Hsieh ◽

I-Shiang Tzeng ◽

Shu-Ya Wu ◽

...

Keyword(s):

Dry Eye ◽

Association Rule ◽

Binary Data ◽

Meta Analysis ◽

Poor Quality ◽

Dry Eye Disease ◽

Eye Disease ◽

Film Instability ◽

Breakup Time

Background: Dry eye disease (DED) has a higher incidence in old age and is seen predominantly in females worldwide. Neurosensory abnormalities, ocular surface inflammation and damage, film instability, and hyperosmolarity are major and proven pathologies responsible for a poor quality of life. Tear breakup time and Schirmer’s I test are predominantly used for the evaluation of primary outcomes in patients undergoing conventional treatment. A previous meta-analysis of some relevant studies proved that combination of acupoints could be more effective than single acupoint treatment. Objectives: The present study aimed to undertake association rule mining and examined the potential kernel acupoint combination in DED treatment constructed from the extracted randomized controlled trials (RCTs) based on a previous meta-analysis. Methods: We summarized 32 acupoints as binary data from the 12 eligible RCTs and analyzed them based on the Apriori algorithm. Results: TE23, BL2, ST2, ST1, EX-HN5, BL1, LI4, ST36, SP6, and KI3 were the 10 most frequently selected acupoints. The major associated rules in combination of acupoints were {TE23, LI4} ≥ {ST1} and {TE23, ST1} ≥ {LI4}, as inferred from 23 association rules. Conclusions: For acupuncture treatment of DED, combined TE23, LI4, and ST1 acupoints could be settled as the kernel of acupoint combination.

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