scholarly journals Determinants of Increased Serum Calprotectin in Patients with Type 2 Diabetes Mellitus

2020 ◽  
Vol 21 (21) ◽  
pp. 8075
Author(s):  
Milou M. Oosterwijk ◽  
Stephan J.L. Bakker ◽  
Tom Nilsen ◽  
Gerjan Navis ◽  
Gozewijn D. Laverman
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Vascular Inflammation ◽  
Strong Association ◽  
Median Serum ◽  
Potential Biomarker ◽  
Calprotectin Level ◽  
Peripheral Artery Diseases

Circulating calprotectin is a potential biomarker for endovascular inflammation in type 2 diabetes mellitus (T2DM). We investigated the determinants of calprotectin and its relationship with the presence of cardiovascular disease (CVD) in 362 T2DM patients included in the Diabetes and Lifestyle Cohort Twente-1 (DIALECT-1) study. Lifestyle exposures, including nutrition, were determined by validated questionnaires. CVD was defined as coronary artery diseases, strokes, and peripheral artery diseases. Median serum calprotectin levels were 1.04 mg/L [IQR: 0.73–1.46 mg/L] and were higher in women (1.11 mg/L) than men (0.96 mg/L, p = 0.007). Current smoking was a major independent determinant of circulating calprotectin, with a 51% higher calprotectin compared to never smoking (p < 0.001). Albuminuria (p = 0.011), former smoking (p = 0.023), and intake of mono- and disaccharides (p = 0.005) also contributed independently to circulating calprotectin. Each incremental increase in calprotectin level was associated with 1.36-times higher odds for CVD (95% CI 1.04–1.77, p = 0.026). In the current study, calprotectin was the only inflammatory parameter significantly associated with CVD. The strong association of circulating calprotectin with smoking, a well-known direct cause of vascular inflammation, and also with CVD, stresses the urge for further research to define its role as a biomarker in T2DM.

scholarly journals Associations of Salivary BPIFA1 Protein in Chronic Periodontitis Patients with Type 2 Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Yue Guo ◽  
Lin-Na Guo ◽  
Jun-Fei Zhu ◽  
Chen-Yi Tang ◽  
Yun-Zhi Feng ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chronic Periodontitis ◽  
Demographic Data ◽  
Fasting Blood Glucose ◽  
Pocket Depth ◽  
Potential Biomarker ◽  
Severe Periodontitis

Aims. To explore the differences in salivary BPI fold containing family A, member 1 (BPIFA1) concentration among type 2 diabetes mellitus (T2DM) subjects with various severities of chronic periodontitis and to determine whether BPIFA1 in saliva can be used as a potential biomarker of T2DM. Methods. Unstimulated saliva samples were collected from 44 subjects with T2DM and 44 without T2DM (NDM). Additionally, demographic data and general health parameters, including fasting blood glucose (FBG) and body mass index (BMI), were collected. We also detected full-mouth clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), bleeding index (BI), and plaque index (PLI). Salivary BPIFA1, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) concentrations were also detected. Results. BPIFA1 in saliva was detected at relatively high levels. T2DM subjects had decreased salivary BPIFA1 concentrations (P=0.031). In T2DM subjects with nonperiodontitis or severe periodontitis, the level of BPIFA1 was significantly lower compared with that of NDM. Salivary TNF-α concentration displayed a similar trend to BPIFA1 in the NDM group. Conclusions. BPIFA1 protein is rich in saliva and might be used as a potential predictive biomarker of T2DM, especially in patients with severe periodontitis and nonperiodontitis. This trial is registered with ChiCTR-ROC-17010310.

scholarly journals Plasma microRNA-192 expression as a potential biomarker of diabetic kidney disease in patients with type 2 diabetes mellitus

2020 ◽  
Vol 9 (6) ◽  
pp. 454-460
Author(s):  
Talaat Abd El Fattah Abdelaty ◽  
Eman Yousef Morsy ◽  
Eman Tayae El-Sayed ◽  
Shimaa Mohamed El-Rahmany ◽  
Sameh Aldesoky Anwar Lashen
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Kidney Disease ◽  
Diabetic Kidney Disease ◽  
Diabetic Kidney ◽  
Potential Biomarker ◽  
Plasma Microrna

scholarly journals Soluble LRIG2 is a potential biomarker for type 2 diabetes mellitus

2021 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Ji Min Kim ◽  
Kyong Hye Joung ◽  
Jun Choul Lee ◽  
Sorim Choung ◽  
Seon Mee Kang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Potential Biomarker

scholarly journals Influence of GSTT1 and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Retinopathy Risk in The Chinese Population: A Case Control Study

2020 ◽  
Author(s):  
Xinqian Geng ◽  
Ling Zha ◽  
Taicheng Zhou ◽  
Yuxin Xiong ◽  
Fan Xu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Chinese Population ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Gstt1 Null Genotype ◽  
Potential Biomarker

Abstract Background: Studies have revealed the association of glutathione S-transferases (GSTM1 and GSTT1) deletion (null) polymorphism with the risks of developing type 2 diabetes mellitus (T2DM) and its complications. The present study aimed to investigate the relationship between GSTT1/ GSTP1 gene polymorphisms and the risks of T2DM and diabetic retinopathy (DR) in a Chinese population.Methods: A total of 336 subjects with T2DM and a defined ophthalmologic status were recruited from the Second People’s Hospital of Yunnan Province between June 2014 and October 2016. Seventy-two age-matched healthy controls were also enrolled. Physical examinations and laboratory tests were performed. The frequencies of GSTT1 and GSTP1 genotypes in all participants were determined by PCR and PCR-restriction fragment length polymorphisms (PCR–RFLP), respectively.Results: Compared with healthy controls, the GSTT1-null genotype was significantly more common in diabetic patients with or without DR (all P < 0.05). However, the frequency of the GSTP1 genotype (AA, GA, GG) was comparable between the two groups. Furthermore, neither the GSTP1 nor GSTT1 genetic polymorphism was associated with the development of DR. In the present study, the risk of developing T2DM was significantly higher in subjects carrying the combined heterozygous GSTP1 (AG) and null GSTT1 genotypes (OR=0.40, 95% CI=0.21-0.74, P=0.02).Conclusions: The deletion of the GSTT1 genotype was associated with a higher risk of developing T2DM, whether alone or in combination with GSTP1, indicating that the null genotype of GSTT1 may serve as a potential biomarker for T2DM in the Chinese population, which is helpful for clinicians to make more effective risk-based decisions.

scholarly journals Influence of GSTT1 and GSTP1 Polymorphisms on Type 2 Diabetes Mellitus and Diabetic Retinopathy Risk in the Chinese Population: A Case Control Study

2020 ◽  
Author(s):  
Xinqian Geng ◽  
Ling Zha ◽  
Taicheng Zhou ◽  
Yixin Xiong ◽  
Fan Xu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
Chinese Population ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Gstt1 Null Genotype ◽  
Potential Biomarker

Abstract Background: Studies have revealed the association of glutathione S-transferases (GSTM1 and GSTT1) deletion (null) polymorphism with the risks of developing type 2 diabetes mellitus (T2DM) and its complications. The present study aimed to investigate the relationship between GSTT1/ GSTP1 gene polymorphisms and the risks of T2DM and diabetic retinopathy (DR) in a Chinese population.Methods: A total of 336 subjects with T2DM and a defined ophthalmologic status were recruited from the Second People’s Hospital of Yunnan Province between June 2014 and October 2016. Seventy-two age-matched healthy controls were also enrolled. Physical examinations and laboratory tests were performed. The frequencies of GSTT1 and GSTP1 genotypes in all participants were determined by PCR and PCR-restriction fragment length polymorphisms (PCR–RFLP), respectively.Results: Compared with healthy controls, the GSTT1-null genotype was significantly more common in diabetic patients with or without DR (all P < 0.05). However, the frequency of the GSTP1 genotype (AA, GA, GG) was comparable between the two groups. Furthermore, neither the GSTP1 nor GSTT1 genetic polymorphism was associated with the development of DR. In the present study, the risk of developing T2DM was significantly higher in subjects carrying the combined heterozygous GSTP1 (AG) and null GSTT1 genotypes (OR=0.40, 95% CI=0.21-0.74, P=0.02).Conclusions: The deletion of the GSTT1 genotype was associated with a higher risk of developing T2DM, whether alone or in combination with GSTP1, indicating that the null genotype of GSTT1 may serve as a potential biomarker for T2DM in the Chinese population, which is helpful for clinicians to make more effective risk-based decisions.

scholarly journals Skinfold thickness and the incidence of type 2 diabetes mellitus and hypertension: an analysis of the PERU MIGRANT study

2019 ◽  
Vol 23 (1) ◽  
pp. 63-71 ◽  
Author(s):  
Andrea Ruiz-Alejos ◽  
Rodrigo M Carrillo-Larco ◽  
J Jaime Miranda ◽  
Robert H Gilman ◽  
Liam Smeeth ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Body Fat ◽  
Strong Association ◽  
Skinfold Thickness ◽  
Fat Percentage ◽  
Urban Migrants ◽  
Incidence Analysis

AbstractObjective:To determine the association between excess body fat, assessed by skinfold thickness, and the incidence of type 2 diabetes mellitus (T2DM) and hypertension (HT).Design:Data from the ongoing PERU MIGRANT Study were analysed. The outcomes were T2DM and HT, and the exposure was skinfold thickness measured in bicipital, tricipital, subscapular and suprailiac areas. The Durnin–Womersley formula and SIRI equation were used for body fat percentage estimation. Risk ratios and population attributable fractions (PAF) were calculated using Poisson regression.Setting:Rural (Ayacucho) and urban shantytown district (San Juan de Miraflores, Lima) in Peru.Participants:Adults (n 988) aged ≥30 years (rural, rural-to-urban migrants, urban) completed the baseline study. A total of 785 and 690 were included in T2DM and HT incidence analysis, respectively.Results:At baseline, age mean was 48·0 (sd 12·0) years and 47 % were males. For T2DM, in 7·6 (sd 1·3) years, sixty-one new cases were identified, overall incidence of 1·0 (95 % CI 0·8, 1·3) per 100 person-years. Bicipital and subscapular skinfolds were associated with 2·8-fold and 6·4-fold risk of developing T2DM. On the other hand, in 6·5 (sd 2·5) years, overall incidence of HT was 2·6 (95 % CI 2·2, 3·1) per 100 person-years. Subscapular and overall fat obesity were associated with 2·4- and 2·9-fold risk for developing HT. The PAF for subscapular skinfold was 73·6 and 39·2 % for T2DM and HT, respectively.Conclusions:We found a strong association between subscapular skinfold thickness and developing T2DM and HT. Skinfold assessment can be a laboratory-free strategy to identify high-risk HT and T2DM cases.

scholarly journals Role of Stress in Newly Detected Type 2 Diabetes Mellitus and Hypertension

2017 ◽  
Vol 6 (2) ◽  
pp. 1493
Author(s):  
Bavneet Kaur ◽  
Upneet Bedi
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Relative Risk ◽  
Life Events ◽  
Stressful Life Events ◽  
Linear Trend ◽  
Strong Association

<p><strong>Background:</strong> Type 2 diabetes mellitus and hypertension are chronic diseases whose prevalence is increasing globally. Cardiovascular disease is a major cause of mortality and morbidity in diabetes and hypertension, and lifestyle and clinical risk factor do not fully account for the link between the conditions.</p><p><strong>Objective:</strong> This study provides an overview of the evidences concerning the role of stressful life events as contributors of increasing the risk of developing type 2 diabetes mellitus and hypertension in the population.</p><p><strong>Material and Methods:</strong> Prospective cross-sectional study comprising of 80 random cases of newly detected type 2 diabetes and hypertension. Strength of association with the outcome endurance of diabetes mellitus and hypertension with stress levels grouped as slight risk, moderate risk and at risk was evaluated and reported as RR (relative risk) with corresponding 95% confidence interval (CI) x^2 used for trend, p-value of &lt;0.05 was considered as statistically significant.</p><p><strong>Results:</strong> Strong association found between exposure to stress and development of type 2 diabetes mellitus (RR=1.51, 95% CI=1.09-2.10) (p=0.02). A positive linear trend was observed between hypertension and stress. For SBP (x^2 for trend=18.5, df=2, p=0.0001 highly significant). DBP 7 times more risk of developing hypertension (RR=7.36, 95% CI=1.27-4.94), p=0.0006 (highly significant).</p><p><strong>Conclusion:</strong> Strong association was found between stress and development of hypertension and type 2 diabetes mellitus. In hypertensive's a positive linear trend was seen between the two variables. In the diabetics, the relative risk with stress was 1.5 times. Stressful life events increase the risk of developing Type2 diabetes and hypertension.</p>

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