scholarly journals Activation of KCNQ4 as a Therapeutic Strategy to Treat Hearing Loss

2021 ◽  
Vol 22 (5) ◽  
pp. 2510
Author(s):  
John Hoon Rim ◽  
Jae Young Choi ◽  
Jinsei Jung ◽  
Heon Yung Gee
Keyword(s):  
Hearing Loss ◽  
Late Onset ◽  
Ion Homeostasis ◽  
Physiological Role ◽  
Voltage Gated ◽  
Age Related ◽  
Gated Channel ◽  
Pros And Cons ◽  
Age Related Hearing Loss

Potassium voltage-gated channel subfamily q member 4 (KCNQ4) is a voltage-gated potassium channel that plays essential roles in maintaining ion homeostasis and regulating hair cell membrane potential. Reduction of the activity of the KCNQ4 channel owing to genetic mutations is responsible for nonsyndromic hearing loss, a typically late-onset, initially high-frequency loss progressing over time. In addition, variants of KCNQ4 have also been associated with noise-induced hearing loss and age-related hearing loss. Therefore, the discovery of small compounds activating or potentiating KCNQ4 is an important strategy for the curative treatment of hearing loss. In this review, we updated the current concept of the physiological role of KCNQ4 in the inner ear and the pathologic mechanism underlying the role of KCNQ4 variants with regard to hearing loss. Finally, we focused on currently developed KCNQ4 activators and their pros and cons, paving the way for the future development of specific KCNQ4 activators as a remedy for hearing loss.

scholarly journals Association of Age-Related Hearing Loss with Cognitive Decline

2020 ◽  
Vol 63 (4) ◽  
pp. 145-153
Author(s):  
Juyong Chung
Keyword(s):  
Hearing Loss ◽  
Cognitive Decline ◽  
Cochlear Implants ◽  
Hearing Aids ◽  
Microvascular Disease ◽  
Single Mechanism ◽  
Hearing Aid Use ◽  
Age Related ◽  
Age Related Hearing Loss

A number of studies have demonstrated a significant association between age-related hearing loss (ARHL) and cognitive decline. However their relationship is not clear. In this review, we focused on the etiological mechanisms between ARHL and cognitive decline to explain the nature of this relationship: 1) causal mechanisms (e.g., cognitive load hypothesis, cascade hypothesis); 2) common cause mechanisms (e.g., microvascular disease); 3) overdiagnosis or harbinger hypothesis. We conclude that no single mechanism is sufficient and hearing and cognition related to each other in several different ways. In addition, we reviewed the effectiveness of hearing intervention (e.g., hearing aids and cochlear implants) on cognition function, and the role of hearing aid use and cochlear implant depends on the relevant mechanism.

Role of general practitioners in managing age‐related hearing loss

2010 ◽  
Vol 192 (1) ◽  
pp. 20-23 ◽  
Author(s):  
Julie M Schneider ◽  
Bamini Gopinath ◽  
Catherine M McMahon ◽  
Helena C Britt ◽  
Christopher M Harrison ◽  
...  
Keyword(s):  
Hearing Loss ◽  
General Practitioners ◽  
Age Related ◽  
Age Related Hearing Loss

scholarly journals The role of the General Practitioner in managing age-related hearing loss: Perspectives of General Practitioners, patients and practice staff

2020 ◽  
Author(s):  
Rebecca Jane Bennett ◽  
Susan Fletcher ◽  
Nicole Conway ◽  
Caitlin Barr
Keyword(s):  
Hearing Loss ◽  
General Practitioner ◽  
Concept Mapping ◽  
Practice Nurses ◽  
Online Portal ◽  
Age Related ◽  
Mapping Techniques ◽  
Age Related Hearing Loss ◽  
Instrumental Role

Abstract Background For people with hearing loss, the General Practitioner (GP) can play an instrumental role in early detection of hearing loss as well as guiding appropriate and timely choices for addressing hearing concerns. The aim of this study was to generate a conceptual framework for understanding the role of the GP in managing age-related hearing loss. Methods Concept mapping techniques were used to gather the perspectives of GPs (n = 8), adults with hearing loss (n = 22), and professionals working with GPs (n = 5), in Australia. Participants generated statements describing the role of the GP in managing age-related hearing loss, and then grouped the statements to identify key themes, via an online portal. Results Ninety-eight items describing the role of the GP in managing age-related hearing loss were identified across six concepts: 1) Determine - Diagnose - Discuss, 2) Ask - Assess - Act, 3) Know - Refer - Coordinate, 4) Inform - Advise - Partner, 5) Educate - Strategise - Encourage, 6) Reassure - Support - Empower. Conclusions The role of the GP in managing age-related hearing loss is multifaceted and requires partnership that motivates and empowers patients’ to overcome their hearing concerns. Enlisting the help of Practice Nurses, Practice Managers and local audiologists could help GPs improve their hearing loss detection and intervention rates.

The Role of the General Practitioner in Managing Age-Related Hearing Loss: A Scoping Review

2020 ◽  
Vol 29 (2) ◽  
pp. 265-289
Author(s):  
Rebecca J. Bennett ◽  
Nicole Conway ◽  
Susan Fletcher ◽  
Caitlin Barr
Keyword(s):  
Older Adults ◽  
Hearing Loss ◽  
General Practitioner ◽  
Bibliographic Databases ◽  
Research Activity ◽  
Screening Programs ◽  
Age Related ◽  
Number Of Patients ◽  
Age Related Hearing Loss

Purpose The purpose of this review was to examine the research activity relating to the role of the general practitioner (GP) in managing age-related hearing loss in older adults. Method A literature search of peer-reviewed journal articles published in English was conducted in online bibliographic databases using multiple variations of the keywords “general practitioner” and “hearing.” Results The search strategy identified 3,255 articles. The abstracts of all articles were screened with 124 full-text records subsequently assessed for eligibility. Forty-nine articles met the inclusion criteria and were included in this review. Conclusions For people with hearing loss, the GP can play an instrumental role in guiding appropriate and timely choices for addressing hearing concerns. There are a range of quick, easy, and sensitive methods available to GPs to assist the objective evaluation of hearing. The evidence suggests that implementing hearing screening programs targeting older adults will increase rates of hearing loss detection and subsequently increase the number of patients receiving hearing loss intervention. Education and training appear key to improving GPs’ screening, management, and referral of patients with hearing loss in the primary health care setting.

scholarly journals Role of melatonin in prevention of age-related hearing loss

PLoS ONE ◽  
2020 ◽  
Vol 15 (2) ◽  
pp. e0228943
Author(s):  
Lucieny Silva Martins Serra ◽  
Juliana Gusmão de Araújo ◽  
Ana Luiza Sarkis Vieira ◽  
Eduardo Magalhães da Silva ◽  
Rafael Rocha de Andrade ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Age Related ◽  
Age Related Hearing Loss

Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss

2007 ◽  
Vol 226 (1-2) ◽  
pp. 185-193 ◽  
Author(s):  
Tatsuya Yamasoba ◽  
Shinichi Someya ◽  
Chikako Yamada ◽  
Richard Weindruch ◽  
Tomas A. Prolla ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Mitochondrial Dna ◽  
Mitochondrial Dysfunction ◽  
Mitochondrial Dna Mutations ◽  
Dna Mutations ◽  
Age Related ◽  
Age Related Hearing Loss
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