scholarly journals The Use of Two-Dimensional Shear Wave Elastography in People with Obesity for the Assessment of Liver Fibrosis in Non-Alcoholic Fatty Liver Disease

2020 ◽  
Vol 10 (1) ◽  
pp. 95
Author(s):  
Ritesh Chimoriya ◽  
Milan K Piya ◽  
David Simmons ◽  
Golo Ahlenstiel ◽  
Vincent Ho
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Severe Obesity ◽  
Shear Wave Elastography ◽  
Two Dimensional ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

Obesity is associated with significant comorbidities, including non-alcoholic fatty liver disease (NAFLD). Given its potential to progress to advanced liver disease, monitoring the extent and progress of liver fibrosis and assessing its fibrosis stage are essential. Although liver biopsy is considered to be the gold standard for liver fibrosis staging, it is an invasive procedure with risk of complications. Considering the rising prevalence of obesity and NAFLD globally, developing non-invasive diagnostic methods is a priority. Transient elastography (TE) is increasingly being used to assess the severity of liver disease. However, in the presence of severe obesity, the increased thickness of subcutaneous adipose tissue and changes in anatomy may affect its diagnostic accuracy. Two-dimensional shear wave elastography (2D-SWE) assesses the liver stiffness in real time along with simultaneous anatomic B-mode ultrasound imaging and allows selection of the region of interest. This would suggest that 2D-SWE has several advantages over TE in patients with severe obesity. The purpose of this review is to examine the current literature addressing the use of 2D-SWE in the assessment of liver fibrosis in patients with NAFLD. This review also examines the evidence on the use of 2D-SWE in patients with obesity and NAFLD and compares it to TE as a novel and non-invasive method of assessing liver fibrosis.

scholarly journals Hepatocellular Carcinoma and Non-Alcoholic Fatty Liver Disease: A Step Forward for Better Evaluation Using Ultrasound Elastography

Cancers ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 2778
Author(s):  
Monica Lupsor-Platon ◽  
Teodora Serban ◽  
Alexandra-Iulia Silion ◽  
Alexandru Tirpe ◽  
Mira Florea
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Shear Wave Elastography ◽  
Ultrasound Elastography ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

The increasing prevalence of non-alcoholic fatty liver disease (NAFLD) in the general population prompts for a quick response from physicians. As NAFLD can progress to liver fibrosis, cirrhosis, and even hepatocellular carcinoma (HCC), new non-invasive, rapid, cost-effective diagnostic methods are needed. In this review, we explore the diagnostic performance of ultrasound elastography for non-invasive assessment of NAFLD and NAFLD-related HCC. Elastography provides a new dimension to the conventional ultrasound examination, by adding the liver stiffness quantification in the diagnostic algorithm. Whilst the most efficient elastographic techniques in staging liver fibrosis in NAFLD are vibration controlled transient elastography (VCTE) and 2D-Shear wave elastography (2D-SWE), VCTE presents the upside of assessing steatosis through the controlled attenuation parameter (CAP). Hereby, we have also critically reviewed the most important elastographic techniques for the quantitative characterization of focal liver lesions (FLLs), focusing on HCC: Point shear wave elastography (pSWE) and 2D-SWE. As our paper shows, elastography should not be considered as a substitute for FLL biopsy because of the stiffness values overlap. Furthermore, by using non-invasive, disease-specific surveillance tools, such as US elastography, a subset of the non-cirrhotic NAFLD patients at risk for developing HCC can be detected early, leading to a better outcome. A recent ultrasomics study exemplified the wide potential of 2D-SWE to differentiate benign FLLs from malignant ones, guiding the clinician towards the next steps of diagnosis and contributing to better long-term disease surveillance.

scholarly journals Non-invasive markers associated with liver fibrosis in non-alcoholic fatty liver disease

Gut ◽  
2006 ◽  
Vol 55 (11) ◽  
pp. 1650-1660 ◽  
Author(s):  
I N Guha ◽  
J Parkes ◽  
P R Roderick ◽  
S Harris ◽  
W M Rosenberg
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

scholarly journals Non-invasive diagnosis of non-alcoholic fatty liver disease in children: role of shear-wave elastography and steatometry

2020 ◽  
Vol 15 (6) ◽  
pp. 409-419
Author(s):  
Yu.M. Stepanov ◽  
N.Yu. Zavhorodnia ◽  
O.Yu. Zavhorodnia ◽  
I.S. Konenko ◽  
V.B. Yagmur ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Shear Wave ◽  
Fatty Liver Disease ◽  
Shear Wave Elastography ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

scholarly journals Diagnostic accuracy of point shear wave elastography and transient elastography for staging hepatic fibrosis in patients with non-alcoholic fatty liver disease: a meta-analysis

BMJ Open ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. e021787 ◽  
Author(s):  
Weixi Jiang ◽  
Sirun Huang ◽  
Hua Teng ◽  
Peipei Wang ◽  
Meng Wu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Shear Wave ◽  
Fatty Liver Disease ◽  
Transient Elastography ◽  
Shear Wave Elastography ◽  
Advanced Fibrosis ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

ObjectiveThis study aimed to assess the accuracy of staging liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) usingpoint shear wave elastography (pSWE) and transient elastography (TE).SettingRelevant records on NAFLD were retrieved from PubMed, Embase, Web of Science and the China National Knowledge Infrastructure databases up to 20 December 2017. A bivariate mixed-effects model was conducted to combine sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and area under the summary receiver operating characteristic curve (AUC) between pSWE and TE. A sensitivity analysis was implemented to explore the source of heterogeneity.ParticipantsPatients with NAFLD who had a liver stiffness measurement using pSWE and TE before liver biopsy were enrolled according to the following criteria: 2×2 contingency tables can be calculated via the reported number of cases; sensitivity and specificity were excluded according to the following criteria: history of other hepatic damage, such as chronic hepatitis C, concurrent active hepatitis B infection, autoimmune hepatitis, suspicious drug usage and alcohol abuse.ResultsNine pSWE studies comprising a total of 982 patients and 11 TE studies comprising a total of 1753 patients were included. For detection of significant fibrosis, advanced fibrosis and cirrhosis, the summary AUC was 0.86 (95% CI 0.83 to 0.89), 0.94 (95% CI 0.91 to 0.95) and 0.95 (95% CI 0.93 to 0.97) for pSWE, and the summary AUC was 0.85 (95% CI 0.82 to 0.88), 0.92 (95% CI 0.89 to 0.94) and 0.94 (95% CI 0.93 to 0.97) for TE, respectively. The proportion of failure measurement was over tenfold as common with TE using an M probe compared with pSWE.ConclusionpSWE and TE, providing precise non-invasive staging of liver fibrosis in NAFLD, are promising techniques, particularly for advanced fibrosis and cirrhosis.

Non-invasive markers to predict the liver fibrosis in non-alcoholic fatty liver disease

2006 ◽  
Vol 26 (7) ◽  
pp. 864-871 ◽  
Author(s):  
Helen Lydatakis ◽  
Ieronymos Philippos Hager ◽  
Eyaggelia Kostadelou ◽  
Stavros Mpousmpoulas ◽  
Stavros Pappas ◽  
...  
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Fatty Liver Disease ◽  
Alcoholic Fatty Liver ◽  
Non Invasive ◽  
Alcoholic Fatty Liver Disease

scholarly journals Correlation Between Point Shear Wave Elastography and Liver Function Tests as A Predictor of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease

2021 ◽  
Vol 15 (6) ◽  
pp. 1990-1994
Author(s):  
Shahla Mohammed Saeed Rasul ◽  
Ali Khalaf Salim ◽  
Hiwa Abubakr Hussein
Keyword(s):  
Liver Disease ◽  
Liver Fibrosis ◽  
Fatty Liver ◽  
Shear Wave ◽  
Fatty Liver Disease ◽  
Shear Wave Elastography ◽  
Liver Function Tests ◽  
Fibrosis Score ◽  
Alcoholic Fatty Liver ◽  
Alcoholic Fatty Liver Disease

Aim: of this study is to correlate between point shear wave elastography(pSWE) and liver function tests (LFTs) to predict liver fibrosis in patients with non-alcoholic fatty liver disease (NAFLD). Materials and methods: this study is a cross sectional study conducted in Ultrasound Clinic in Suleymaniya city. The duration of the study was through the period from 1st of November, 2018 to 30th of June, 2019 on 50 NAFLD patients. After confirming NAFLD diagnosis, the patients were referred to Ultrasound Clinic to complete Point Shear Wave Elastography (PSWE). Results: showed a mean PSWE of NAFLD patient was 4.12±0.87 Kpa; 18% of them had high PSWE (> 4.6). Elastography fibrosis score was distributed to F0 (82%), F1 (6%), F2 (8%) and F3 (4%). The Aspartate Aminotransferase Platelet Ratio Index (APRI) fibrosis scores were distributed to F0 (48%), F1-3 (48%) and F4 (4%), There was a highly significant association between elastography fibrosis score and APRI fibrosis score of NAFLD patients (p<0.001), There was no significant association between elastography fibrosis score and Aspartate Aminotransferase/Alanine Aminotransferase (AST/ALT) values of NAFLD patients (p=0.5). Conclusion: this study showed that the point shear wave elastography is a valuable noninvasive diagnostic technique for predicting significant liver fibrosis among patients with non-alcoholic liver fatty diseases and there is significant correlation between APRI score and pSWE score. The current gold standard in the diagnosis and staging of liver fibrosis is liver biopsy. Point shear wave elastography is among the noninvasive procedures to assess liver fibrosis. Keywords: Non-alcoholic fatty liver disease, Point shears wave elastography, Liver fibrosis.

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