Complex Liver Resections for Intrahepatic Cholangiocarcinoma

The only curative treatment option for intrahepatic cholangiocarcinoma (iCCA) is liver resection. Due to central tumor localization and vascular invasion, complex liver resections play an important role in curative treatment. However, the long-term outcomes after complex liver resection are not known. Methods: A retrospective cohort study was conducted for all patients undergoing liver surgery for iCCA. Complex liver resections included ante situm resections, associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) and major liver resection with vascular reconstructions. Results: Forty-nine patients (34%) received complex liver resection, 66 patients (46%) received conventional liver resection and 28 patients (20%) were not resectable during exploration. Preoperative characteristics were not different between the groups, except for Union for International Cancer Control (UICC) stages. The postoperative course for complex liver resections was associated with more complications and perioperative mortality. However, long-term survival was not different between complex and conventional resections. Independent risk factors for survival were R0 resections and UICC stage. Four patients underwent ante situm resection without any mortality. Conclusions: Complex liver resections are justified in selected patients and survival is comparable with conventional liver resections. Survival in iCCA is affected by UICC stage or resections margins and not by the complexity of the case.

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A novel online prognostic tool to predict long‐term survival after liver resection for intrahepatic cholangiocarcinoma: The “metro‐ticket” paradigm

Journal of Surgical Oncology ◽

10.1002/jso.25480 ◽

2019 ◽

Cited By ~ 2

Author(s):

Kota Sahara ◽

Diamantis I. Tsilimigras ◽

Rittal Mehta ◽

Fabio Bagante ◽

Alfredo Guglielmi ◽

...

Keyword(s):

Liver Resection ◽

Intrahepatic Cholangiocarcinoma ◽

Term Survival ◽

Long Term Survival ◽

Prognostic Tool

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Conditional Probability of Long-term Survival After Liver Resection for Intrahepatic Cholangiocarcinoma

JAMA Surgery ◽

10.1001/jamasurg.2015.0219 ◽

2015 ◽

Vol 150 (6) ◽

pp. 538 ◽

Cited By ~ 53

Author(s):

Gaya Spolverato ◽

Yuhree Kim ◽

Aslam Ejaz ◽

Sorin Alexandrescu ◽

Hugo Marques ◽

...

Keyword(s):

Liver Resection ◽

Conditional Probability ◽

Intrahepatic Cholangiocarcinoma ◽

Term Survival ◽

Long Term Survival

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Liver Resections for Metastases from Intraabdominal Leiomyosarcoma

HPB Surgery ◽

10.1155/1999/67324 ◽

1999 ◽

Vol 11 (4) ◽

pp. 261-264 ◽

Cited By ~ 3

Author(s):

Antonio Nocchi Kalil ◽

Bianca De Lourdes Pereira ◽

Marcia Cristina Lima Brenner ◽

Luiz Pereira-Lima

Keyword(s):

Liver Resection ◽

Liver Metastases ◽

Surgical Indication ◽

Extrahepatic Disease ◽

Term Survival ◽

Long Term Survival ◽

Liver Resections

This paper discusses liver resection for intraabdominal leiomyosarcoma metastases as a therapy for carefully selected patients. Of the 83 hepatectomies performed from 1992 to 1996, five were resections for liver metastases due to intraabdominal leiomyosarcoma, in 3 patients. The surgical indication was single liver metastases, without any evidence of extrahepatic disease. No mortality occurred during surgery and the longest survival was 38 months. We concluded that liver resection for leiomyosarcoma metastases can be performed, allowing a long term survival in an occasional patient.

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Liver and Pancreatic Resection in the Elderly

HPB Surgery ◽

10.1155/1997/84160 ◽

1997 ◽

Vol 10 (4) ◽

pp. 259-261 ◽

Cited By ~ 2

Author(s):

O. J. Garden

Keyword(s):

Survival Rate ◽

Liver Resection ◽

Mortality Rate ◽

Elderly Patients ◽

Complication Rate ◽

Pancreatic Resection ◽

The Elderly ◽

Term Survival ◽

Pancreatic Resections

Background: Liver resection, or pancreaticoduodenectomy, has traditionally been thought to have a high morbidity and. mortality rate among the elderly. Recent improvements in surgical and anesthetic techniques, an increasing number of elderly patients, and an increasing need to justify use of limited health care resources prompted an assessment of recent surgical outcomes.Methods: Five hundred seventy-seven liver resections (July 1985–July 1994) performed for metastatic colorectal cancer and 488 pancreatic resections (October 1983–July 1994) performed for pancreatic malignancies were identified in departmental data bases. Outcomes of patients younger than age 70 years were compared with those of patients age 70 years or older.Results: Liver resection for 128 patients age 70 years or older resulted in a 4% perioperative. mortality rate and a 42% complication rate. Median hospital stay was 13 days, and 8% of the patients required admission to the intensive care unit (ICU). Median survival was 40 months, and the 5-year survival rate was 35%. No difference were found between results for the elderly and those for younger patients who had undergone liver resection, except for a minimally shorter hospital stay fortheyoungerpatients (median, 12 days vs. 13 days p=0.003). Pancreatic resection for 138 elderly patients resulted in a mortality rate of 6% and a complication rate of 45%. Median stay was 20 days, and 19% of the patients required ICU admission, results identical to those for the younger cohort. Long-term survival was poorer for the elderly patients, with a 5-year survival rate of 21% compared with 29% for the younger cohort (p=0.03).Conclusions: Major liver or pancreatic resections can be performed for the elderly with acceptable morbidity and mortality rates and possible long-term survival. Chronologic age alone is not a contraindication to liver or pancreatic resection for malignancy.

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P-166 Re-hepatectomy is a predictor of long-term survival in patients that recur after liver resection of colorectal liver metastases

Annals of Oncology ◽

10.1093/annonc/mdw199.160 ◽

2016 ◽

Vol 27 ◽

pp. ii49

Author(s):

M. Marques ◽

H.S. de Castro Ribeiro ◽

W.L. Costa ◽

A.L. Diniz ◽

A. Godoy ◽

...

Keyword(s):

Liver Resection ◽

Liver Metastases ◽

Colorectal Liver Metastases ◽

Term Survival ◽

Long Term Survival

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The relationship between postoperative complications and long-term survival after liver resection of hepatocellular carcinoma

European Journal of Gastroenterology & Hepatology ◽

10.1097/meg.0000000000000966 ◽

2017 ◽

Vol 29 (11) ◽

pp. 1314-1315 ◽

Cited By ~ 1

Author(s):

Zheng Wang ◽

Yi-Sheng Huang ◽

Jun Han ◽

Chao Li ◽

Tian Yang

Keyword(s):

Hepatocellular Carcinoma ◽

Liver Resection ◽

Postoperative Complications ◽

Term Survival ◽

Long Term Survival ◽

The Relationship

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Impact of postoperative complications on long-term survival of hepatocellular carcinoma patients after liver resection

International Surgery ◽

10.9738/intsurg-d-21-00010.1 ◽

2021 ◽

Author(s):

Susumu Mochizuki ◽

Hisashi Nakayama ◽

Yutaka Midorikawa ◽

Tokio Higaki ◽

Masamichi Moriguchi ◽

...

Keyword(s):

Hepatocellular Carcinoma ◽

Overall Survival ◽

Liver Resection ◽

Pleural Effusion ◽

Postoperative Complications ◽

Recurrence Free Survival ◽

Term Survival ◽

Free Survival ◽

Long Term Survival

Objective The effect of postoperative complications including red blood transfusion (BT) on long-term survival for hepatocellular carcinoma (HCC) is unknown. The purpose of this study was to define the relationship between postoperative complications and long-term survival in patients with HCC. Methods Postoperative complications of 1251 patients who underwent curative liver resection for HCC were classified, and their recurrence-free survival (RFS) and cumulative overall survival (OS) were investigated. Results Any complications occurred in 503 patients (40%). Five-year RFS and 5-year OS in the complication group were 21% and 56%, respectively, significantly lower than the respective values of 32% ( p < 0.001) and 68% ( p < 0.001) in the no-complication group (n=748). Complications related to RFS were postoperative BT [Hazard ratio (HR): 1.726, 95% confidence interval (CI): 1.338–2.228, p < 0.001], pleural effusion [HR: 1.434, 95% CI: 1.200–1.713, p < 0.001] using Cox-proportional hazard model. Complications related to OS were postoperative BT [HR: 1.843, 95%CI: 1.380-2.462, p < 0.001], ascites [HR: 1.562, 95% CI: 1.066–2.290 p = 0.022], and pleural effusion [HR: 1.421, 95% CI: 1.150–1.755, p = 0.001). Conclusions Postoperative complications were factors associated with poor long-term survival. Postoperative BT and pleural effusion, were noticeable complications that were prognostic factors for both recurrence-free survival and overall survival.

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The impact of the recurrent laryngeal nerve injury on prognosis after McKeown esophagectomy for ESCC

10.21203/rs.3.rs-88872/v1 ◽

2020 ◽

Author(s):

Rirong Qu ◽

Dehao Tu ◽

Wei Ping ◽

Qi Wang ◽

Ni Zhang ◽

...

Keyword(s):

Risk Factors ◽

Recurrent Laryngeal Nerve ◽

Recurrent Laryngeal Nerve Injury ◽

Laryngeal Nerve ◽

Term Survival ◽

Laryngeal Nerve Injury ◽

Independent Risk Factors ◽

Mckeown Esophagectomy ◽

The Impact

Abstract Background: The objective of this study was to assess the impact of the recurrent laryngeal nerve injury (RLNI) after esophagectomy on prognosis.Methods: Retrospectively collected data from 297 patients with esophageal squamous cell carcinoma who underwent McKeown esophagectomy at our department from April 2014 to May 2018, were analyzed.Results: RLNI occurred in 31.9% of the patients. Left-side RLNI occurred 2.8 times more often than right-side RLNI. Among the cases in which assessment of the vocal cords was continued, 8.4% involved permanent injury. There were no significant differences among clinicopathological data between patients with RLNI and without. Compared with patients without RLNI,patients with RNLI have longer operation time,more number of bronchoscopy suctions, longer postoperation hospital stay, and higher incidence of postoperative complications. T stage, N stage, RLN LN metastasis were independent risk factors for the prognosis, but RLNI is not independent risk factors for long-term survival. Conclusion: RLNI is a serious complication that will affect the short-term prognosis of patients and reduce the quality of life of patients. It should be avoided as much as possible during surgery, but it may not have negative impact on the long-term survival.

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