scholarly journals Visual Acuity and Number of Amniotic Membrane Layers as Indicators of Efficacy in Amniotic Membrane Transplantation for Corneal Ulcers: A Multicenter Study

2021 ◽  
Vol 10 (15) ◽  
pp. 3234
Author(s):  
Javier Lacorzana ◽  
Antonio Campos ◽  
Marina Brocal-Sánchez ◽  
Juan Marín-Nieto ◽  
Oswaldo Durán-Carrasco ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Success Rate ◽  
Amniotic Membrane ◽  
Multicenter Study ◽  
Amniotic Membrane Transplantation ◽  
Entire Cohort ◽  
Corneal Ulcers ◽  
Eyelid Malposition ◽  
Retrospective Multicenter Study ◽  
Better Than

Background: To evaluate new indicators in the efficacy of amniotic membrane transplantation (AMT) for non-healing corneal ulcers (NHCUs). Methods: Retrospective, multicenter study. In total, 223 AMTs for NHCU in 191 patients were assessed. The main outcomes studied were the success rate of AMT (complete re-epithelization), postoperative visual acuity (VA) gain, and number of AM layers transplanted. Results: The overall AMT success rate was 74.4%. In 92% of our patients VA stability or improvement. Postoperative VA was significantly higher than preoperative VA in the entire cohort (p < 0.001) and in all etiological groups of ulcers (post-bacterial, p ≤ 0.001; post-herpetic, p ≤ 0.0038; neurotrophic ulcers, p ≤ 0.014; non-rheumatic peripheral, p ≤ 0.001; and ulcers secondary to lagophthalmos and eyelid malposition or trauma, p ≤ 0.004). Most participants (56.5%) presented a preoperative VA equal to or less than counting fingers (≤0.01). Of these, 13.5% reached a postoperative VA equal to or better than legal blindness (≥0.05) after AMT. A higher success rate was observed in the monolayer than in the multilayer AMT (79.5% and 64.9%, respectively; p = 0.018). No statistically significant values were found between the number of layers transplanted and VA gain (p = 0.509). Conclusion: AMT is not only beneficial in achieving complete re-epithelialization in NHCUs but also in improving postoperative VA; these improvements are independent of etiologies of ulcers. Furthermore, the use of monolayer AMT seems to be a more appropriate option than multilayer AMT for NHCU since the multilayer AMT did not present better outcomes (success rate and VA gain) compared to monolayer AMT in the different types of ulcers studied.

scholarly journals Comparison of amniotic membrane transplantation with and without cultured limbal epithelium for persistent corneal ulcers

2021 ◽  
Vol 35 (1) ◽  
pp. 739-745
Author(s):  
Rozaliya Hristova ◽  
Yani Zdravkov ◽  
Georgi Markov ◽  
Davide Borroni ◽  
Alexander Oscar ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers ◽  
Limbal Epithelium

Role of multilayered amniotic membrane transplantation for the treatment of resistant corneal ulcers in North India

2013 ◽  
Vol 34 (3) ◽  
pp. 485-491 ◽  
Author(s):  
Shalini Mohan ◽  
Ina Budhiraja ◽  
Amit Saxena ◽  
Perwez Khan ◽  
S. K. Sachan
Keyword(s):  
Amniotic Membrane ◽  
North India ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

Sutureless “Contact Lens Sandwich” Technique for Amniotic Membrane Therapy of Central Corneal Ulcers

2021 ◽  
pp. 112067212110490
Author(s):  
Saverio V. Luccarelli ◽  
Edoardo Villani ◽  
Stefano Lucentini ◽  
Francesco Bonsignore ◽  
Matteo Sacchi ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Contact Lens ◽  
Low Cost ◽  
Healing Time ◽  
Amniotic Membrane Transplantation ◽  
Recurrence Rates ◽  
Sandwich Technique ◽  
Corneal Ulcers ◽  
Bandage Contact Lens ◽  
Ring Complex

Purpose To describe a new technique for sutureless and glue-free amniotic membrane transplantation (AMT) and to investigate its effectiveness to treat corneal persistent epithelial defects (PEDs), compared to bandage contact lens (BCL) application alone. Methods We performed AMT with “contact lens sandwich technique” (CLS-AMT) in 8 consecutive patients with central/para-central (up to 4.00 mm from the geometrical centre) PED/ulceration and we retrospectively compared the results with 11 BCL procedures. Results The procedures were performed successfully with no complications. CLS-AMT showed significantly shorter healing time than BCL (24.0  ±  19.1 vs 42.9  ±  14.6 days; P < 0.05, Mann-Whitney test). Recurrence rates were 12% and 27% for CLS-AMT and BCL, respectively. Conclusion CLS-AMT technique, based on the suction effect due to the superposition of a bandage contact lens on the AM-ring complex, represents a quick, low cost, easy to perform and nearly non-invasive AMT technique. This approach is able to provide adequate fixation of AM, and it seems to be a safe and effective treatment for patients with PEDs.

A multicenter retrospective study on cryopreserved amniotic membrane transplantation for the treatment of complicated corneal ulcers in the dog

2019 ◽  
Vol 22 (5) ◽  
pp. 695-702 ◽  
Author(s):  
Daniel Costa ◽  
Marta Leiva ◽  
Fernando Sanz ◽  
Victoria Espejo ◽  
Javier Esteban ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

scholarly journals Efficacy of Amniotic Membrane Transplantation for the Treatment of Corneal Ulcers

Cornea ◽  
2020 ◽  
Vol 39 (4) ◽  
pp. 479-483 ◽  
Author(s):  
Kaspar Schuerch ◽  
Andrea Baeriswyl ◽  
Beatrice E. Frueh ◽  
Christoph Tappeiner
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

scholarly journals Active Pedicle Epithelial Flap Transposition Combined with Amniotic Membrane Transplantation for Treatment of Nonhealing Corneal Ulcers

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Ting Zhang ◽  
Yuexin Wang ◽  
Yanni Jia ◽  
Dongle Liu ◽  
Suxia Li ◽  
...  
Keyword(s):  
Confocal Microscopy ◽  
Amniotic Membrane ◽  
Ulcer Healing ◽  
Laser Scanning ◽  
Corneal Ulcer ◽  
Anterior Segment ◽  
Healing Time ◽  
Stevens Johnson Syndrome ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

Introduction. The objective was to evaluate the efficacy of active pedicle epithelial flap transposition combined with amniotic membrane transplantation (AMT) in treating nonhealing corneal ulcers.Material and Methods. Eleven patients (11 eyes) with nonhealing corneal ulcer who underwent the combined surgery were included. Postoperatively, ulcer healing time was detected by corneal fluorescein staining. Visual acuity, intraocular pressure, surgical complications, and recurrence were recorded. Corneal status was inspected by the laser scanning confocal microscopy and anterior segment optical coherence tomography (AS-OCT).Results. The primary diseases were herpes simplex keratitis (8 eyes), corneal graft ulcer (2 eyes), and Stevens-Johnson syndrome (1 eye). All epithelial flaps were intact following surgery, without shedding or displacement. Mean ulcer healing time was10.8±3.1days, with a healing rate of 91%. Vision significantly improved from 1.70 to 0.82 log MAR (P=0.001). A significant decrease in inflammatory cell infiltration and corneal stromal edema was revealed 2 months postoperatively by confocal microscopy and AS-OCT. Corneal ulcer recurred in 1 eye. None of the patients developed major complications.Conclusion. Active pedicle epithelial flap transposition combined with AMT is a simple and effective treatment for nonhealing corneal ulcers.

Amniotic Membrane Transplantation in Refractory Neurotrophic Corneal Ulcers

Cornea ◽  
2005 ◽  
Vol 24 (6) ◽  
pp. 654-660 ◽  
Author(s):  
Sudarshan Khokhar ◽  
Tanie Natung ◽  
Parul Sony ◽  
Namrata Sharma ◽  
Nutan Agarwal ◽  
...  
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Corneal Ulcers

scholarly journals Characteristics of New Onset Herpes Simplex Keratitis after Keratoplasty

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaolin Qi ◽  
Miaolin Wang ◽  
Xiaofeng Li ◽  
Yanni Jia ◽  
Suxia Li ◽  
...  
Keyword(s):  
Visual Acuity ◽  
Herpes Simplex ◽  
Amniotic Membrane ◽  
Antiviral Treatment ◽  
Corneal Thickness ◽  
Clinical Manifestations ◽  
Corneal Graft ◽  
Amniotic Membrane Transplantation ◽  
Herpes Simplex Keratitis ◽  
New Onset

Purpose. To observe clinical characteristics and treatment outcomes of new onset herpes simplex keratitis (HSK) after keratoplasty. Methods. Among 1,443 patients (1,443 eyes) who underwent keratoplasty (excluding cases of primary HSK) in Shandong Eye Hospital, 17 patients suffered postoperative HSK. The clinical manifestations, treatment regimens, and prognoses of the patients were evaluated. Results. The incidence of new onset HSK after keratoplasty was 1.18%. Epithelial HSK occurred in 10 eyes, with dendritic epithelial infiltration in 6 eyes and map-like epithelial defects in 4 eyes. Nine eyes had lesions at the junction of the graft and recipient. Stromal necrotic and endothelial HSK occurred in 7 eyes, presenting map-shaped ulcers in the entire corneal graft and recipient (two eyes) or at the graft-recipient junction (five eyes). Confocal microscopy revealed infiltration of a large number of dendritic cells at the junction of the lesion and transparent cornea. All 10 eyes with epithelial lesions and two eyes suffering stromal lesions of ≤1/3 corneal thickness healed after systematic and local antiviral treatment. Best-corrected visual acuity and corneal graft transparency were restored. For stromal HSK with an ulcer of >1/3 corneal thickness, amniotic membrane transplantation was performed, and visual acuity and graft transparency decreased significantly. Conclusion. New onset HSK after keratoplasty primarily resulted in epithelial and stromal lesion, involving both the graft and recipient. Effective treatments included antiviral medications and amniotic membrane transplantation. Delayed treatment may lead to aggravated graft opacification.

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