scholarly journals Fecal Levels of Lactic, Succinic and Short-Chain Fatty Acids in Patients with Ulcerative Colitis and Crohn Disease: A Pilot Study

2021 ◽  
Vol 10 (20) ◽  
pp. 4701
Author(s):  
Olga Kaczmarczyk ◽  
Agnieszka Dąbek-Drobny ◽  
Michał Woźniakiewicz ◽  
Paweł Paśko ◽  
Justyna Dobrowolska-Iwanek ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fatty Acids ◽  
Organic Acids ◽  
Disease Activity ◽  
Organic Acid ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Control Group ◽  
Biological Drugs ◽  
Chain Fatty Acids

Intestinal dysbiosis plays a crucial role in the development of inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC). The importance of bacterial metabolites, such as short-chain fatty acids (SCFAs), succinic and lactic acids, as well as environmental factors that affect their production in the course of IBD, remains unclear. The aim of this study was to evaluate a profile of organic acids in the stool of CD and UC patients with different disease activity. We assessed a correlation between used medications, patient’s diet, and SCFA levels. A total of 35 adult patients were included in the study. We did not observe significant differences in the levels of organic acids between the CD and UC groups, irrespective of disease activity, and a control group. However, propionic acid levels were higher in IBD patients who received trimebutine vs. those who did not (p = 0.031). Higher isobutyric acid levels were observed in patients treated with biological drugs compared with those without such treatment (p = 0.014). No significant correlations were found between organic acid levels and the frequency of dietary fiber consumption. Our results reveal a new link between medication use and organic acid levels in patients with IBD.

Short-chain fatty acids and distal ulcerative colitis: A meta-analysis study

2001 ◽  
Vol 33 ◽  
pp. A68
Author(s):  
A. D'Arienzo ◽  
R. Bennato ◽  
F. Manguso ◽  
G. Vicinanza ◽  
M. Sanges ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fatty Acids ◽  
Meta Analysis ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Analysis Study ◽  
Distal Ulcerative Colitis ◽  
Chain Fatty Acids

scholarly journals Fecal Bile Acids and Fecal Short Chain Fatty Acids in Patients with Irritable Bowel Syndrome and Control Volunteers

2018 ◽  
Vol 1 (1) ◽  
Author(s):  
Chirag Patel ◽  
Carolyn Lockett ◽  
Huiping Xu ◽  
Andrea Shin
Keyword(s):  
Fatty Acids ◽  
Irritable Bowel Syndrome ◽  
Organic Acids ◽  
Bile Acids ◽  
Short Chain Fatty Acids ◽  
Small Sample ◽  
Short Chain ◽  
Fecal Bile Acids ◽  
Irritable Bowel ◽  
Chain Fatty Acids

Background and Aims: Fecal bile acids (BAs), short chain fatty acids (SCFAs), and gut microbiome may be implicated in irritable bowel syndrome (IBS) pathophysiology. Our aim was to compare fecal organic acids between IBS with constipation (IBS-C), IBS with diarrhea (IBS-D), and controls.   Methods: Stool samples were collected from 17 controls, 5 IBS-C, and 5 IBS-D volunteers during a 4-day high fat diet. Aliquots were stored for future analysis of the fecal microbiota. Fecal SCFA and BA analyses were conducted at the Metabolite Profiling Facility at Purdue University and Laboratory Medicine and Pathology at Mayo Clinic. We compared SCFA and BA levels among groups using the Wilcoxon rank sum test. Gamma and linear regression were used to compare SCFAs and BAs adjusting for age and body mass index (BMI).  Results: Fecal acetate levels (mean+SD, µg/mg) were higher in IBS-C (11.3±7) than in controls (6.1±3.3) or IBS-D (7.7±2), although not statistically significant (p=0.19). Total fecal BAs (median [IQR], %) were higher in IBS-D (675 [484-778]) than in controls (342 [130-640]) or IBS-C (321.5 (34.5-718); however, differences were not significant. No significant differences were observed in BAs or SCFAs between groups in multivariate analyses.  Conclusion: We are unable to show significant differences in organic acid levels in IBS and controls. Lack of association may be due to small sample size. Future investigation of larger patient numbers with incorporation of transit and microbiome analyses may shed further light on the role of organic acids in IBS to identify new biomarkers and treatment targets.

scholarly journals Inulin-type fructans improve active ulcerative colitis associated with microbiota changes and increased short-chain fatty acids levels

Gut Microbes ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 334-357 ◽  
Author(s):  
Rosica Valcheva ◽  
Petya Koleva ◽  
Inés Martínez ◽  
Jens Walter ◽  
Michael G. Gänzle ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Active Ulcerative Colitis ◽  
Chain Fatty Acids

Synbiotics impact on dominant faecal microbiota and short-chain fatty acids production in sows

2019 ◽  
Vol 366 (13) ◽  
Author(s):  
Katarzyna Śliżewska ◽  
Agnieszka Chlebicz
Keyword(s):  
Fatty Acids ◽  
Intestinal Microbiota ◽  
High Performance ◽  
Anaerobic Bacteria ◽  
Short Chain Fatty Acids ◽  
Feed Additives ◽  
Short Chain ◽  
Control Group ◽  
The Impact ◽  
Chain Fatty Acids

ABSTRACT The aim of this study was to estimate the influence of synbiotics on intestinal microbiota and its metabolism in sows. Three different synbiotics were administered with feed to animals from three experimental groups. Two groups of sows were given commercially available probiotics (BioPlus 2B®, Cylactin® LBC) as forage additives for comparison. The control group of sows was given unmodified fodder. The study was conducted for 48 days (10 days before farrowing, and continued 38 days after) and faeces samples were collected four times. The scope of this work was to designate the dominant microbiota in sows’ faeces. Therefore, the total number of anaerobic bacteria, Bifidobacterium sp., Lactobacillus sp., Bacteroides sp., Clostridium sp., Enterococcus sp., Enterobacteriaceae, Escherichia coli and yeast was determined, using the plate method. Changes in the concentration of lactic acid, short-chain fatty acids (SCFAs) and branched-chain fatty acids (BCFAs) were also determined in correlation with the feed additives administered to the sows using high-performance liquid chromatography analysis (HPLC). Our results allowed us to conclude that synbiotics have a beneficial effect on intestinal microbiota of sows and its metabolism. We observed that the impact of the synbiotics on the microbiota was more significant than the one induced by probiotics.

Rectal irrigation with short-chain fatty acids for distal ulcerative colitis

1991 ◽  
Vol 36 (2) ◽  
pp. 185-187 ◽  
Author(s):  
Richard I. Breuer ◽  
Stephen K. Buto ◽  
Miriam L. Christ ◽  
Judy Bean ◽  
Piero Vernia ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Fatty Acids ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Distal Ulcerative Colitis ◽  
Chain Fatty Acids
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