Poorly Differentiated Thyroid Carcinoma: Single Centre Experience and Review of the Literature

There is controversy in the literature regarding a distinct subset of thyroid carcinoma whose histologically classification falls between well-differentiated and anaplastic carcinomas, previously identified as ‘poorly differentiated thyroid carcinoma’ (PDTC), or ‘insular carcinoma’, in view of the peculiar morphological characteristics of the cell groupings. The correct diagnosis and treatment of this entity have important prognostic and therapeutic significance. In this review, we describe the epidemiology, diagnosis, and management of PDTC and report our single centre experience to add to the limited evidence existing in the literature.

Download Full-text

Oncocytic variant of poorly differentiated thyroid carcinoma: “Is diagnosis possible by fine-needle aspiration?”

CytoJournal ◽

10.4103/1742-6413.192188 ◽

2016 ◽

Vol 13 ◽

pp. 23 ◽

Cited By ~ 5

Author(s):

Mine Onenerk ◽

Sule Canberk ◽

Pembegul Gunes ◽

Murat Erkan ◽

Gamze Z. Kilicoglu

Keyword(s):

Thyroid Carcinoma ◽

Needle Aspiration ◽

Differentiated Thyroid Carcinoma ◽

Rare Entity ◽

Fine Needle ◽

Poorly Differentiated Thyroid Carcinoma ◽

Oncocytic Variant ◽

Poorly Differentiated ◽

Characteristic Features ◽

Well Differentiated

Poorly differentiated thyroid carcinoma (PDTC) is a very rare entity, and the diagnosis can be made on histopathology specimens. However, recognition of characteristic features of PDTC is significant on fine-needle aspirations (FNAs) to differentiate this entity from well-differentiated and anaplastic thyroid carcinomas. Here, we present an FNA case concordant with “oncocytic variant of PDTC” and discuss whether definitive diagnosis can be given on FNAs to assess the prognosis in clinically inoperable patients.

Download Full-text

Papillary Thyroid Carcinoma with High-Grade Features Versus Poorly Differentiated Thyroid Carcinoma: An Analysis of Clinicopathologic and Molecular Features and Outcome

Thyroid ◽

10.1089/thy.2020.0668 ◽

2020 ◽

Author(s):

Kristine S Wong ◽

Fei Dong ◽

Milhan Telatar ◽

Jochen Lorch ◽

Erik K Alexander ◽

...

Keyword(s):

Papillary Thyroid Carcinoma ◽

Thyroid Carcinoma ◽

Differentiated Thyroid Carcinoma ◽

High Grade ◽

Papillary Thyroid ◽

Poorly Differentiated Thyroid Carcinoma ◽

Molecular Features ◽

Poorly Differentiated

Download Full-text

Unusual Finding on Ultrasonography of Follicular Thyroid Carcinoma Including Poorly Differentiated Thyroid Carcinoma

Thyroid ◽

10.1089/thy.2008.0060 ◽

2008 ◽

Vol 18 (9) ◽

pp. 1021-1022 ◽

Cited By ~ 1

Author(s):

Minoru Kihara ◽

Nobuyuki Amino ◽

Mitsuyoshi Hirokawa ◽

Fumio Matsuzuka ◽

Akira Miyauchi

Keyword(s):

Thyroid Carcinoma ◽

Follicular Thyroid Carcinoma ◽

Differentiated Thyroid Carcinoma ◽

Poorly Differentiated Thyroid Carcinoma ◽

Poorly Differentiated ◽

Unusual Finding

Download Full-text

Poorly Differentiated Thyroid Carcinoma with Adenoid-Cystic Like Cytomorphology: A Potential Diagnostic Pitfall

Journal of the American Society of Cytopathology ◽

10.1016/j.jasc.2021.07.094 ◽

2021 ◽

Vol 10 (5) ◽

pp. S55

Author(s):

Yazeed Alwelaie ◽

Doaa Alghamdi ◽

Ali Howaidi ◽

Moammar Muzzaffar ◽

Hisham Said

Keyword(s):

Thyroid Carcinoma ◽

Differentiated Thyroid Carcinoma ◽

Poorly Differentiated Thyroid Carcinoma ◽

Diagnostic Pitfall ◽

Adenoid Cystic ◽

Poorly Differentiated

Download Full-text

Abstract #1004276: Rapidly Progressive Disease Burden of Metastatic Poorly Differentiated Thyroid Carcinoma in a Patient with Familial Adenomatous Polyposis (FAP)

Endocrine Practice ◽

10.1016/j.eprac.2021.04.846 ◽

2021 ◽

Vol 27 (6) ◽

pp. S178

Author(s):

Anthony Chuang ◽

Kristen M. Gonzales ◽

Patricia L. Kapsner

Keyword(s):

Familial Adenomatous Polyposis ◽

Thyroid Carcinoma ◽

Disease Burden ◽

Progressive Disease ◽

Differentiated Thyroid Carcinoma ◽

Adenomatous Polyposis ◽

Poorly Differentiated Thyroid Carcinoma ◽

Poorly Differentiated

Download Full-text

Atypical Features Resembling Poorly Differentiated Thyroid Carcinoma Presenting Entirely within a Follicular Adenoma

Case Reports in Pathology ◽

10.1155/2018/7290343 ◽

2018 ◽

Vol 2018 ◽

pp. 1-4

Author(s):

Daniel Ching ◽

Connull Leslie

Keyword(s):

Thyroid Carcinoma ◽

Unusual Case ◽

Follicular Adenoma ◽

Differentiated Thyroid Carcinoma ◽

Follicular Neoplasm ◽

Poorly Differentiated Thyroid Carcinoma ◽

Biological Potential ◽

Poorly Differentiated ◽

High Mitotic Count ◽

Widely Invasive

Poorly differentiated thyroid carcinoma (PDTC) is rare and is usually widely invasive at presentation. Here we present an unusual case with a component meeting diagnostic criteria for PDTC by Turin consensus proposal arising within a follicular adenoma. A 44-year-old female was found to have an incidental right thyroid nodule that was suggestive of follicular neoplasm on FNA. Histological examination of hemithyroidectomy revealed an 11 mm focus with insular growth pattern, alteration in cell morphology, and high mitotic count meeting criteria for PDTC. In addition there were several regions showing trabecular architecture with increased mitotic activity but not meeting criteria for PDTC. The literature for such cases is sparse but suggests much better prognosis than conventional invasive PDTC, although a biological potential for aggressive behaviour may be possible.

Download Full-text