Hybrid Imaging in Head and Neck Sarcoidosis

To determine the prevalence of head and neck sarcoidosis (HNS) and evaluate the role of hybrid molecular imaging in HNS. Between 2010 and 2018, 222 patients with chronic sarcoidosis and presence of prolonged symptoms of active disease were referred to FDG PET/CT. Active disease was found in 169 patients, and they were all screened for the presence of HNS. All patients underwent MDCT and assessment of the serum ACE level. Follow-up FDG PET/CT examination was done 19.84 ± 8.98 months after the baseline. HNS was present in 38 out of 169 patients. FDG uptake was present in: cervical lymph nodes (38/38), submandibular glands (2/38), cerebrum (2/38), and bone (1/38). The majority of patients had more than two locations of disease. After FDG PET/CT examination, therapy was changed in most patients. Fourteen patients returned to follow-up FDG PET/CT examination in order to assess the therapy response. PET/CT revealed active disease in 12 patients and complete remission in two patients. Follow-up ACE levels had no correlation with follow-up SUVmax level (ρ = −0.18, p = 0.77). FDG PET/CT can be useful in the detection of HNS and in the evaluation of the therapy response. It may replace the use of non-purposive mounds of insufficiently informative laboratory and radiological procedures.

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Hybrid Imaging in Evaluation of Abdominal Sarcoidosis

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405614666180531111616 ◽

2018 ◽

Vol 15 (1) ◽

pp. 26-31 ◽

Cited By ~ 1

Author(s):

Isidora Grozdic Milojevic ◽

Dragana Sobic-Saranovic ◽

Nebojsa Petrovic ◽

Slobodanka Beatovic ◽

Marijana Tadic ◽

...

Keyword(s):

Fdg Pet ◽

Therapy Response ◽

Ct Examination ◽

Abdominal Disease ◽

Pet Ct ◽

Fdg Pet Ct ◽

Total Remission ◽

Active Disease

Objective: To determine the prevalence of abdominal involvement, distribution pattern and evaluate role of hybrid molecular imaging in patients with abdominal sarcoidosis. Methods: Between January 2010 and December 2011, 98 patients with chronic sarcoidosis and presence of prolonged symptoms or other findings suggestive of active disease were referred to FDG PET/CT examination. Active disease was found in 82 patients, and they all were screened for the presence of abdominal sarcoidosis on FDG PET/CT. All patients also underwent MDCT and assessment of serum ACE level. Follow up FDG PET/CT examination was done 12.3±5.4 months after the baseline. Results: Abdominal sarcoidosis was present in 31/82 patients with active sarcoidosis. FDG uptake was present in: retroperitoneal lymph nodes (77%), liver (26%), spleen (23%), adrenal gland (3%). Majority of patients had more than two locations of disease. Usually thoracic disease was spread into the extrathoracic localizations, while isolated abdominal sarcoidosis was present in 10% of patients. After first FDG PET/CT examination therapy was changed in all patients. Eleven patients came to the follow up examination where SUVmax significantly decreased in the majority of them. Three patients had total remission, three had absence of abdominal disease but discrete findings in thorax and others had less spread disease. ACE levels did not correlate with SUVmax level. Conclusion: FDG PET/CT can be a useful tool for detection of abdominal sarcoidosis and in the evaluation of therapy response in these patients. Awareness of the presence of intra-abdominal sarcoidosis is important in order to prevent long-standing unrecognized disease.

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Combined Evaluation of FDG-PET/CT and CT Imaging Characteristics of Cervical Lymph Nodes to Increase the Interpretation Accuracy for Nodal Metastatic Involvement in Head and Neck Cancer

otolaryngology ◽

10.4172/2161-119x.1000213 ◽

2015 ◽

Vol 05 (06) ◽

Author(s):

Richard A Marshall ◽

Peter M Som ◽

Livnat Uliel

Keyword(s):

Head And Neck Cancer ◽

Lymph Nodes ◽

Head And Neck ◽

Neck Cancer ◽

Fdg Pet ◽

Cervical Lymph Nodes ◽

Imaging Characteristics ◽

Pet Ct ◽

Metastatic Involvement ◽

Fdg Pet Ct

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18F-FDG PET/CT and MRI in the follow-up of head and neck squamous cell carcinoma

Contrast Media & Molecular Imaging ◽

10.1002/cmmi.425 ◽

2011 ◽

Vol 6 (4) ◽

pp. 260-266 ◽

Cited By ~ 11

Author(s):

Rose Ghanooni ◽

Isabelle Delpierre ◽

Michèle Magremanne ◽

Catherine Vervaet ◽

Nicolas Dumarey ◽

...

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Fdg Pet ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct ◽

Ct And Mri

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Incidental Findings on FDG PET/CT in Head and Neck Cancer

Otolaryngology ◽

10.1177/0194599817742579 ◽

2017 ◽

Vol 158 (3) ◽

pp. 484-488 ◽

Cited By ~ 9

Author(s):

Christopher J. Britt ◽

Austin M. Maas ◽

Tabassum A. Kennedy ◽

Gregory K. Hartig

Keyword(s):

Head And Neck Cancer ◽

Head And Neck ◽

Neck Cancer ◽

Fdg Pet ◽

Incidental Findings ◽

Ct Imaging ◽

Additional Patient ◽

Pet Ct ◽

Fdg Pet Ct

Objective 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG PET/CT) imaging is common in head and neck cancer and often identifies incidental findings that necessitate additional patient evaluations. Our goal was to assess the frequency and nature of these incidental imaging findings on FDG-PET/CT. Study Design Retrospective cohort study. Setting Tertiary medical center. Subjects and Methods All patients with head and neck cancer who had undergone FDG-PET/CT imaging between January 2014 and June 2015 at our institution were evaluated for incidental findings. Results A total of 293 patients met criteria; more than one-third (n = 103) had at least 1 finding unrelated to their head and neck cancer, for a total of 134 incidental findings. Incidental findings within the head and neck (33.5% of all) excluding the thyroid were most common: 35% incidental findings were concerning for malignancy; of these, 25.5% were malignant with further workup. Recommendations were given by the head and neck radiologist on 72 (53.7%) findings: 74.5% of potentially malignant findings and 42.5% of benign findings had recommendations for follow-up. Significantly more patients with findings described as malignant were given recommendations for follow-up ( P = .0004). Conclusion Incidental findings on FDG-PET/CT are present in more than one-third of patients with head and neck cancer. More than one-third of incidental findings were concerning for malignancy. This study illustrates how the incidental findings discovered on FDG PET/CT frequently necessitate additional evaluations unrelated to the index head and neck cancer. The impact of these additional assessments on the cost and quality of health care warrants future evaluation.

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18F-FDG-PET/CT-guided radiotherapy of cervical lymph nodes in head and neck squamous cell carcinoma

10.20517/2394-4722.2021.55 ◽

2021 ◽

Author(s):

Maurice C. Cox ◽

Sven van den Bosch ◽

Tim Dijkema ◽

Johannes H.A.M. Kaanders

Keyword(s):

Squamous Cell Carcinoma ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Head And Neck ◽

Fdg Pet ◽

Cervical Lymph Nodes ◽

Ct Guided ◽

Pet Ct ◽

18F Fdg ◽

Fdg Pet Ct

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Comparison of subjective evaluation versus objective algorithm in the interpretation of follow-up FDG-PET/CT scans after radiochemotherapy in head and neck cancer patients

Nuklearmedizin ◽

10.1055/a-0859-6518 ◽

2019 ◽

Vol 58 (02) ◽

pp. 93-100 ◽

Cited By ~ 1

Author(s):

Alexander Kohler ◽

Steffen Löck ◽

Steffen Appold ◽

Anna Bandurska-Luque ◽

Sebastian Hoberück ◽

...

Keyword(s):

Diagnostic Accuracy ◽

Head And Neck ◽

Fdg Pet ◽

Distant Metastases ◽

Ct Scans ◽

Experienced Observer ◽

Pet Ct ◽

Objective Classification ◽

Fdg Pet Ct

Abstract Aim Retrospective evaluation of serial FDG-PET/CT scans in head and neck squamous cell cancer (HNSCC) patient’s follow-up after primary radiochemotherapy (RCTx), to assess the diagnostic accuracy of an experienced observer vs. an objective classification compared to standard clinical follow-up examinations. Methods Sixty-nine patients with locally advanced HNSCC were included, who received curative RCTx. Follow-up included serial FDG-PET/CT at the following time intervals t1: ≤ 270 d, t2: 271–540 d, t3: > 540 d after curative RCTx. The likelihood to detect local recurrences, nodal and distant metastases were compared between (i) experienced observer, (ii) an objective classification system by Zundel et al. 25, and (iii) routine clinical follow-up examinations. Results Twenty-two local recurrences, 7 nodal and 17 distant metastases were recorded during the follow-up. The diagnostic accuracy for local recurrence of the experienced observer vs. objective classification was 78 % vs. 77 % for t1, 83 % vs. 79 % for t2 and 100 % vs. 84 % for t3.The classification (ii) and the conventional follow-up (iii) resulted in a relatively high amount of equivocal findings reducing the diagnostic accuracy. Conclusion Evaluation of FDG-PET/CT by an experienced observer in follow-up of HNSCC patients after curative RCTx resulted in the highest diagnostic accuracy in comparison to an objective classification and to routine clinical examination.HNSCC is a malignant tumor with a high likelihood of recurrence, especially in the first two years after curative RCTx. Early detection of recurrence is of high clinical importance, since there are several effective second line therapies that may have curative potential in some patients.

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Role of follow-up (FU) FDG-PET/CT (FU-FDG-PET/CT) in patients with locoregionally advanced squamous cell carcinoma of the head and neck (LA-HNSCC) treated with chemotherapy and radiotherapy (RT), either concurrent (CRT) or sequential (ST)

Annals of Oncology ◽

10.1093/annonc/mdz252.045 ◽

2019 ◽

Vol 30 ◽

pp. v467

Author(s):

B. Van Den Heuvel ◽

C. Van Laer ◽

P.M.C. Specenier

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Squamous Cell ◽

Fdg Pet ◽

Advanced Squamous Cell Carcinoma ◽

Pet Ct ◽

Fdg Pet Ct

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FDG-PET/CT in the Assessment of Treatment Response after Oncologic Treatment of Head and Neck Squamous Cell Carcinoma

Clinical Medicine Insights Ear Nose and Throat ◽

10.4137/cment.s16399 ◽

2014 ◽

Vol 7 ◽

pp. CMENT.S16399 ◽

Cited By ~ 6

Author(s):

Harri Keski-Säntti ◽

Timo Mustonen ◽

Jukka Schildt ◽

Kauko Saarilahti ◽

Antti A. Mäkitie

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Head And Neck ◽

Treatment Response ◽

Predictive Value ◽

Fdg Pet ◽

Residual Disease ◽

Pet Ct ◽

Fdg Pet Ct

Background In many centers, 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG–PET/CT) is used to monitor treatment response after definitive (chemo)radiotherapy [(C)RT] for head and neck squamous cell carcinoma (HNSCC), but its usefulness remains somewhat controversial. We aimed at assessing the accuracy of FDG-PET/CT in detecting residual disease after (C)RT. Method All HNSCC patients with FDG-PET/CT performed to assess treatment response 10–18 weeks after definitive (C)RT at our institution during 2008–2010 were included. The patient charts were reviewed for FDG-PET/CT findings, histopathologic findings, and follow-up data. The median follow-up time for FDG-PET/CT negative patients was 26 months. Results Eighty-eight eligible patients were identified. The stage distribution was as follows: I, n = 1; II, n = 15; III, n = 17; IV, n = 55. The negative predictive value, positive predictive value, specificity, sensitivity, and accuracy of FDG-PET/CT in detecting residual disease were 87%, 81%, 94%, 65%, and 85%, respectively. The corresponding specific figures for the primary tumor site were 91%, 71%, 94%, 59%, and 86% and for the neck 93%, 100%, 100%, 75%, and 94%, respectively. Conclusions In patients who have received definitive (C)RT for HNSCC, post-treatment FDG-PET/CT has good potential to guide clinical decision-making. Patients with negative scan can safely be followed up clinically only, while positive scan necessitates tissue biopsies or a neck dissection to rule out residual disease.

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