Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland

The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69–44.01; p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01–0.37; p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02–0.59; p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.

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Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

Archives of Pathology & Laboratory Medicine ◽

10.5858/2002-126-1104-daccot ◽

2002 ◽

Vol 126 (9) ◽

pp. 1104-1105 ◽

Cited By ~ 4

Author(s):

Simonetta Piana ◽

Alberto Cavazza ◽

Corrado Pedroni ◽

Rosa Scotti ◽

Luigi Serra ◽

...

Keyword(s):

Salivary Gland ◽

Parotid Gland ◽

Cell Carcinoma ◽

Clinical Course ◽

Acinic Cell Carcinoma ◽

Low Grade ◽

High Grade ◽

Epithelial Proliferation ◽

Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

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Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland

Virchows Archiv ◽

10.1007/s004280050353 ◽

1999 ◽

Vol 434 (4) ◽

pp. 361-365 ◽

Cited By ~ 38

Author(s):

S. Di Palma ◽

Valentina Corletto ◽

Cinzia Lavarino ◽

Sarah Birindelli ◽

Silvana Pilotti

Keyword(s):

Parotid Gland ◽

Cell Carcinoma ◽

Acinic Cell Carcinoma ◽

Low Grade ◽

Acinic Cell

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ACINIC CELL CARCINOMA OF PAROTID GLAND – A CASE REPORT

10.36106/gjra/6812340 ◽

2020 ◽

pp. 66-67

Author(s):

J. Priyadharisini ◽

Partho Protim Barman ◽

U. Bharathi

Keyword(s):

Differential Diagnosis ◽

Salivary Gland ◽

Parotid Gland ◽

Cell Carcinoma ◽

Histopathological Examination ◽

Acinic Cell Carcinoma ◽

Low Grade ◽

Diagnostic Dilemma ◽

Gold Standard Method ◽

Acinic Cell

Acinic cell carcinoma (ACC) is a rare type of tumor which accounts for only 1–3% of the salivary gland tumors. Majority of which occurs in the parotid gland. ACC can be misinterpreted as benign because of its low grade histology. Radiological imaging techniques have low sensitivity in detecting malignancy of parotid glands. Guided FNAC can prove to be reliable diagnostic modality that can help in differential diagnosis of salivary gland neoplasms. Aspirates from these tumors can be diagnostically challenging. The lesions that have to be considered in the differential diagnosis include a wide variety of nonneoplastic as well as neoplastic conditions and pose a serious diagnostic dilemma cytologically. Hence histopathological examination is the gold standard method of choice for diagnosing these tumors. Here we report a case of Acinic cell carcinoma of parotid gland which had cytological diagnostic dilemma and confirmed diagnosis following histopathology examination.

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UNUSUAL PRESENTATION OF ACINIC CELL CARCINOMA OF THE RIGHT PAROTID GLAND WITH LOCOREGIONAL LYMPH NODE METASTASIS IN A 18 YEARS OLD MALE: A CASE REPORT WITH REVIEW OF LITERATURE

International Journal of Medical and Biomedical Studies ◽

10.32553/ijmbs.v3i6.337 ◽

2019 ◽

Vol 3 (6) ◽

Author(s):

Dr. Anuradha Kusum ◽

Dr. Sushil Kumar Shukla ◽

Dr. Nadia Shirazi ◽

Dr. Dushyant Singh Gaur ◽

Dr. S.S. Bisht

Keyword(s):

Parotid Gland ◽

Lymph Nodes ◽

Cell Carcinoma ◽

Secretory Granules ◽

Main Tool ◽

Acinic Cell Carcinoma ◽

Pathological Examination ◽

Low Grade ◽

Acinic Cell ◽

Slow Growing

Acinic cell carcinoma (ACC) is a slow growing and low grade epithelial neoplasm of the salivary glands, in which few tumor cells exhibiting acinar cell differentiation that is characterized by presence of cytoplasmic zymogen secretory granules in the tumor cell. Most frequently ACC occur in parotid gland with the initial presentation somewhat at younger age than other parotid gland neoplasms and preferentially more in female with female: male ratio is 3:2 and median age at time of presentation is 52 years. “Fine needle aspiration cytology (FNAC)” examination may also be useful tool for confirmation of the diagnosis. The treatment of tumor is essentially by surgical excision of the gland. In histo-pathological examination; the most common presentation of tumor is solid sheet and nesting pattern of the growth followed by microcystic, papillary-cystic and follicular pattern . The purpose of the present case is to present the clinical, cytological and histopathological features of of ACC of the parotid glands of 18 years old male child which initially present as a benign cystic lesion of parotid gland than finally diagnosed as ACC with metastasized to regional lymph nodes. To conclude, ACC is frequently arising in parotid gland and metastasis to the intra-salivary gland lymph nodes is a very rare finding in young male. Intra-operative frozen section might be helpful in the diagnosis of parotid gland ACC because of low specificity and sensitivity of CT scan and FNAC examination of ACC. The histo-morphological examination of paraffin embedded H/E stained section is the main tool to explain the microscopic findings of ACC and to classify ACC of parotid gland. Specail stain like PAS, PAS-D and IHC examination might useful for diagnosis of ACC. Surgery with adjuvant post-operative radiation therapy is acceptable for final outcome of disease and the tumor should be managed uncompromisingly, despite of its slow growing and low malignant behaviour, due to its metastatic prospective which usually confirmed by distant metastasis and recurrence. Hence, these tumors require a long-term follow-up. Key words: ACC: Acinic cell carcinoma

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