scholarly journals Dedifferentiated Acinic Cell Carcinoma of the Parotid Gland With Myoepithelial Features

2002 ◽  
Vol 126 (9) ◽  
pp. 1104-1105 ◽  
Author(s):  
Simonetta Piana ◽  
Alberto Cavazza ◽  
Corrado Pedroni ◽  
Rosa Scotti ◽  
Luigi Serra ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Clinical Course ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
High Grade ◽  
Epithelial Proliferation ◽  
Acinic Cell

Abstract Dedifferentiated acinic cell carcinoma of the salivary gland is an uncommon variant of acinic cell carcinoma, characterized by the coexistence of both an usual low-grade acinic cell carcinoma and a high-grade dedifferentiated component, as well as by an accelerated clinical course. We describe a case of acinic cell carcinoma of the parotid gland in a 67-year-old woman, which recurred 4 times after surgery and radiotherapy. The recurrences consisted of residual foci of acinic cell carcinoma intermingled with a high-grade epithelial proliferation; the latter was focally constituted by cells with morphologic and immunohistochemical features of myoepithelium.

scholarly journals ACINIC CELL CARCINOMA OF PAROTID GLAND – A CASE REPORT

2020 ◽  
pp. 66-67
Author(s):  
J. Priyadharisini ◽  
Partho Protim Barman ◽  
U. Bharathi
Keyword(s):  
Differential Diagnosis ◽  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Histopathological Examination ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Diagnostic Dilemma ◽  
Gold Standard Method ◽  
Acinic Cell

Acinic cell carcinoma (ACC) is a rare type of tumor which accounts for only 1–3% of the salivary gland tumors. Majority of which occurs in the parotid gland. ACC can be misinterpreted as benign because of its low grade histology. Radiological imaging techniques have low sensitivity in detecting malignancy of parotid glands. Guided FNAC can prove to be reliable diagnostic modality that can help in differential diagnosis of salivary gland neoplasms. Aspirates from these tumors can be diagnostically challenging. The lesions that have to be considered in the differential diagnosis include a wide variety of nonneoplastic as well as neoplastic conditions and pose a serious diagnostic dilemma cytologically. Hence histopathological examination is the gold standard method of choice for diagnosing these tumors. Here we report a case of Acinic cell carcinoma of parotid gland which had cytological diagnostic dilemma and confirmed diagnosis following histopathology examination.

scholarly journals Nodal Metastases in Acinic Cell Carcinoma of the Parotid Gland

2019 ◽  
Vol 8 (9) ◽  
pp. 1315 ◽  
Author(s):  
Stefan Grasl ◽  
Stefan Janik ◽  
Matthaeus C. Grasl ◽  
Johannes Pammer ◽  
Michael Formanek ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Disease Free Survival ◽  
Retrospective Chart Review ◽  
Acinic Cell Carcinoma ◽  
Elective Neck Dissection ◽  
Low Grade ◽  
Acinic Cell ◽  
Neck Metastases ◽  
High Grade Carcinoma

The objective of this study was to evaluate the clinical outcome of patients with acinic cell carcinomas of the parotid gland after elective neck dissection (END). A retrospective chart review was performed including 66 patients with acinic cell carcinoma of the parotid gland. Clinical parameters were retrieved and statistically analyzed regarding disease-free survival (DFS) and disease-specific survival (DSS). An END was done in 27 (40.9%) patients, and occult metastases were detected in 4 (14.8%) patients of whom three were low-grade carcinoma. Positive neck nodes were associated with significantly worse DSS (p = 0.05). Intermediate and high-grade carcinoma (HR 8.62; 95% confidence interval (CI): 1.69–44.01; p = 0.010), perineural invasion (HR 19.6; 95%CI: 0.01–0.37; p = 0.003) and lymphovascular invasion (HR 10.2; 95%CI: 0.02–0.59; p = 0.011) were worse prognostic factors for DFS. An END should be considered in patients with acinic cell carcinoma of the parotid gland due to (i) a notable rate of occult neck metastases in low-grade tumors and (ii) the worse DSS of patients with positive neck nodes.

scholarly journals Oncogenic Orphan Nuclear Receptor NR4A3 Interacts and Cooperates with MYB in Acinic Cell Carcinoma

Cancers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2433
Author(s):  
David Y. Lee ◽  
Kathryn J. Brayer ◽  
Yoshitsugu Mitani ◽  
Eric A. Burns ◽  
Pulivarthi H. Rao ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
Salivary Gland Tumor ◽  
Binding Domain ◽  
Acinic Cell Carcinoma ◽  
High Grade ◽  
Orphan Nuclear Receptor ◽  
Acinic Cell ◽  
High Grade Transformation ◽  
Domain Transformation

Acinic cell carcinoma (AcCC) is a morphologically distinctive salivary gland malignancy often associated with chromosome rearrangements leading to overexpression of the NR4A3 transcription factor. However, little is known about how NR4A3 contributes to AcCC biology. Detailed RNA-sequencing of 21 archived AcCC samples revealed fusion reads arising from recurrent t(4;9), t(9;12), t(8;9) or t(2;4) chromosomal translocations, which positioned highly active enhancers adjacent to the promoter of the NR4A3 gene or the closely related NR4A2 gene, resulting in their aberrant overexpression. Transcriptome analyses revealed several distinct subgroups of AcCC tumors, including a subgroup that overexpressed both NR4A3 and MSANTD3. A poor survival subset of the tumors with high-grade transformation expressed NR4A3 and POMC as well as MYB, an oncogene that is the major driver in a different type of salivary gland tumor, adenoid cystic carcinoma. The combination of NR4A3 and MYB showed cooperativity in regulating a distinct set of genes. In addition, the ligand binding domain of NR4A3 directly bound the Myb DNA binding domain. Transformation assays indicated that, while overexpressed NR4A3 was sufficient to generate transformed colonies, the combination of NR4A3 plus Myb was more potent, leading to anchorage-independent growth and increased cellular invasiveness. The results confirm that NR4A3 and NR4A2 are the main driver genes of AcCC and suggest that concurrent overexpression of NR4A3 and MYB defines a subset of AcCC patients with high-grade transformation that display exceptionally poor outcome.

Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland

1999 ◽  
Vol 434 (4) ◽  
pp. 361-365 ◽  
Author(s):  
S. Di Palma ◽  
Valentina Corletto ◽  
Cinzia Lavarino ◽  
Sarah Birindelli ◽  
Silvana Pilotti
Keyword(s):  
Parotid Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Acinic Cell

Familial Occurrence of Acinic Cell Carcinoma of the Parotid Gland

1999 ◽  
Vol 123 (11) ◽  
pp. 1118-1120 ◽  
Author(s):  
Peter L. Depowski ◽  
Gavin Setzen ◽  
Alex Chui ◽  
Peter J. Koltai ◽  
James Dollar ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Acinic Cell Carcinoma ◽  
Familial Occurrence ◽  
Salivary Gland Neoplasm ◽  
Warthin Tumor ◽  
Lymphoepithelial Lesion ◽  
Acinic Cell ◽  
Left Parotid Gland

Abstract We report the familial occurrence of acinic cell carcinoma involving the parotid gland, the first such report of which we are aware. The familial occurrence of any salivary gland neoplasm is rare. Several reports are present in the literature, including pleomorphic adenoma, Warthin tumor, carcinoma of the submandibular gland, and malignant lymphoepithelial lesion. We report the case of a 35-year-old man who underwent excision of a left parotid gland acinic cell carcinoma. Eight years later, his daughter presented at the age of 16 years with a nontender parotid gland mass that was excised and found also to be acinic cell carcinoma. The histologic features of both neoplasms were typical of acinic cell carcinoma. While this may represent a coincidental event, the possibility that this familial occurrence is a manifestation of common genetic or environmental risk cannot be excluded.

Acinic Cell Carcinoma-Papillary Cystic Variant with numerous psammoma body: A Case Report

2019 ◽  
Vol 9 (9) ◽  
pp. 592-595
Author(s):  
Daniyah Saleh, MD, Doaa Al ghamdi*, MD
Keyword(s):  
Salivary Gland ◽  
Cell Carcinoma ◽  
University Hospital ◽  
Acinic Cell Carcinoma ◽  
Low Grade ◽  
Psammoma Body ◽  
Acinic Cell ◽  
Common Location ◽  
King Abdulaziz University ◽  
Proper Diagnosis

Acinic cell carcinoma (ACC) is a rare, low-grade malignant salivary gland neoplasm.Parotid gland is the most common location reaching up to 90% of cases. Papillarycystic variant (PCV) is a much more seldom subtype of ACC. Proper diagnosis ofACC-PCV is only made on histopathology examination. The presence of psammomabody in salivary gland lesions is infrequent finding that may be confused with otherbenign or malignant lesions. The present case describes ACC-PCV in a 31-year-oldSaudi male patient referred to King Abdulaziz University Hospital as post superficialparotidectomy which the patient underwent 3 months ago. This case emphasizesthe importance of distinguishing between neoplastic and non-neoplastic lesions withnumerous psammoma bodies.Key words: papillary cystic acinic cell carcinoma–psammoma body–histopathology–parotid gland.

Parotid acinic cell carcinoma with undifferentiated spindle cell transformation

1994 ◽  
Vol 108 (10) ◽  
pp. 902-904
Author(s):  
Jorge A. Ferreiro ◽  
Amarjit S. Kochar
Keyword(s):  
Salivary Gland ◽  
Parotid Gland ◽  
Cell Carcinoma ◽  
Spindle Cell ◽  
Cell Transformation ◽  
Acinic Cell Carcinoma ◽  
Similar Lesion ◽  
Acinic Cell ◽  
Black Man

AbstractThis report describes a 59-year-old black man who had an acinic cell carcinoma with associated malignant spindle cell transformation in the parotid gland. To the best of our knowledge, a similar lesion in the salivary gland has not been previously reported.

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