scholarly journals Plagiocephaly after Neonatal Developmental Dysplasia of the Hip at School Age

2019 ◽  
Vol 9 (1) ◽  
pp. 21 ◽  
Author(s):  
Valkama ◽  
Aarnivala ◽  
Sato ◽  
Harila ◽  
Heikkinen ◽  
...  
Keyword(s):  
Hip Joint ◽  
Preventive Measures ◽  
Developmental Dysplasia ◽  
Anthropometric Measurements ◽  
Length Ratio ◽  
School Age Children ◽  
School Age ◽  
Cephalic Index ◽  
Deformational Plagiocephaly ◽  
Dysplasia Of The Hip

Developmental dysplasia of the hip (DDH) may require early abduction treatment with infants sleeping on their back for the first few months of life. As sleeping on back is known to cause deformational plagiocephaly, we assessed school age children treated for dislocation or subluxation of the hip-joint in infancy. Plagiocephaly was analyzed by using cephalic index (CI) and oblique cranial length ratio (OCLR) as anthropometric measurements from 2D digital vertex view photographs. Six of the 58 (10.3%) DDH children and only one of the 62 (1.6%) control children had plagiocephaly (p = 0.041). Furthermore, cross bite was found in 14 (24.1%) of the DDH children and in 7 (10.3%) of the control children. Developmental dysplasia of the hip in infancy was associated with cranial asymmetries and malocclusions at school age. Preventive measures should be implemented.

scholarly journals Corrective Intertrochanteric Osteotomy of the Femur for Aseptic Necrosis of the Femoral Head after Bloodless Reduction of Congenital Dislocation in School-Age Children

2021 ◽  
Vol 07 (10) ◽  
Author(s):  
Khojaakhmed Shaykhislamovich Alpysbaev ◽  
Keyword(s):  
Femoral Head ◽  
Hip Joint ◽  
Hip Dislocation ◽  
School Age Children ◽  
Congenital Dislocation ◽  
School Age ◽  
Greater Trochanter ◽  
Congenital Hip Dislocation ◽  
Aseptic Necrosis ◽  
Results Of Treatment

The immediate results of treatment of 72 children aged 7 to 12 years with aseptic necrosis of the femoral head after bloodless reduction of congenital hip dislocation were analyzed. When treating patients, the following types of surgical treatment were used:extra-articular or open centering of the femoral head with intertrochanteric-torsion-varizing or devarizing and rotational osteotomy of the femur with bringing down the greater trochanter in the caudal direction. In all patients, pain and lameness disappeared, internal rotation of the lower extremities when walking, and the range of motion in the hip joint improved. Improved radiometric parameters characterizing the ratio of the acetabulum and the head of the femur and the angular values of the hip joint and proximal femur.

scholarly journals Prevalence of back pain and the knowledge of preventive measures in a cohort of 11619 Polish school-age children and youth—an epidemiological study

Medicine ◽  
2019 ◽  
Vol 98 (22) ◽  
pp. e15729 ◽  
Author(s):  
Agnieszka Kędra ◽  
Aleksandra Kolwicz-Gańko ◽  
Dominik Sitarski ◽  
Przemysław Kędra ◽  
Dariusz Czaprowski
Keyword(s):  
Back Pain ◽  
Epidemiological Study ◽  
Preventive Measures ◽  
Children And Youth ◽  
School Age Children ◽  
School Age ◽  
Polish School

scholarly journals Expression of PAPP-A2 and IGF Pathway-Related Proteins in the Hip Joint of Normal Rat and Those with Developmental Dysplasia of the Hip

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Yufan Chen ◽  
Haixiang Lv ◽  
Lianyong Li ◽  
Enbo Wang ◽  
Lijun Zhang ◽  
...  
Keyword(s):  
Growth Factor ◽  
Hip Joint ◽  
Developmental Dysplasia ◽  
Insulin Like Growth Factor ◽  
Hip Joints ◽  
Fetal Rats ◽  
Associated Proteins ◽  
Normal Rat ◽  
Related Proteins ◽  
Dysplasia Of The Hip

Developmental dysplasia of the hip (DDH) is one of the major causes of child disability and early osteoarthritis. Genetic factors play an important role, but which still remain unclear. Pregnancy-associated plasma protein-A2 (PAPP-A2), a special hydrolase of insulin-like growth factor binding protein-5 (IGFBP-5), has been confirmed to be associated with DDH by previous studies. The aim of this study was firstly, to investigate the expression of PAPP-A2 and insulin-like growth factor (IGF) pathway-related proteins in normal rat’s hip joints; secondly, to compare the variations of those proteins between DDH model rats and normal ones. The DDH model was established by swaddling the rat’s hind legs in hip adduction and extension position. The hip joints were collected for expression study of fetal rats, normal newborn rats, and DDH model rats. Positive expression of PAPP-A2 and IGF pathway-related proteins was observed in all the hip joints of growing-stage rats. Ultimately, IGF1 was downregulated; insulin-like growth factor 1 receptor (IGF1R) showed an opposite trend in DDH rats when compared with normal group. The PAPP-A2 and IGF pathway-associated proteins may also be involved in the development of the rat’s hip joint, which bring the foundation for further revealing the pathogenic mechanism of DDH.

scholarly journals Comprehensive analysis of pathological changes in hip joint capsule of patients with developmental dysplasia of the hip

2021 ◽  
Vol 10 (9) ◽  
pp. 558-570
Author(s):  
Chuan Li ◽  
Zhi Peng ◽  
You Zhou ◽  
Yongyue Su ◽  
Pengfei Bu ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Differentially Expressed Genes ◽  
Hip Joint ◽  
Cyclin B1 ◽  
Developmental Dysplasia ◽  
Joint Capsule ◽  
Differentially Expressed ◽  
Healthy Controls ◽  
Collagen Fibres ◽  
Dysplasia Of The Hip

Aims Developmental dysplasia of the hip (DDH) is a complex musculoskeletal disease that occurs mostly in children. This study aimed to investigate the molecular changes in the hip joint capsule of patients with DDH. Methods High-throughput sequencing was used to identify genes that were differentially expressed in hip joint capsules between healthy controls and DDH patients. Biological assays including cell cycle, viability, apoptosis, immunofluorescence, reverse transcription polymerase chain reaction (RT-PCR), and western blotting were performed to determine the roles of the differentially expressed genes in DDH pathology. Results More than 1,000 genes were differentially expressed in hip joint capsules between healthy controls and DDH. Both gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses revealed that extracellular matrix (ECM) modifications, muscle system processes, and cell proliferation were markedly influenced by the differentially expressed genes. Expression of Collagen Type I Alpha 1 Chain (COL1A1), COL3A1, matrix metalloproteinase-1 (MMP1), MMP3, MMP9, and MMP13 was downregulated in DDH, with the loss of collagen fibres in the joint capsule. Expression of transforming growth factor beta 1 (TGF-β1) was downregulated, while that of TGF-β2, Mothers against decapentaplegic homolog 3 (SMAD3), and WNT11 were upregulated in DDH, and alpha smooth muscle actin (αSMA), a key myofibroblast marker, showed marginal increase. In vitro studies showed that fibroblast proliferation was suppressed in DDH, which was associated with cell cycle arrest in G0/G1 and G2/M phases. Cell cycle regulators including Cyclin B1 (CCNB1), Cyclin E2 (CCNE2), Cyclin A2 (CCNA2), Cyclin-dependent kinase 1 (CDK1), E2F1, cell division cycle 6 (CDC6), and CDC7 were downregulated in DDH. Conclusion DDH is associated with the loss of collagen fibres and fibroblasts, which may cause loose joint capsule formation. However, the degree of differentiation of fibroblasts to myofibroblasts needs further study. Cite this article: Bone Joint Res 2021;10(9):558–570.

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