Investigation of Meibomian Gland Function and Dry Eye Disease in Patients with Graves’ Ophthalmopathy

We prospectively evaluated the relationship between meibomian gland dysfunction (MGD) and Graves’ ophthalmopathy (GO) in 19 patients (38 eyes) with subjective dry eye symptoms, compared to 14 age-matched normal participants (14 eyes). Extraocular muscle and lacrimal gland enlargement were evaluated by magnetic resonance imaging (MRI). Ocular surface examinations included fluorescein staining for keratoconjunctival epithelial damage, tear breakup time (TBUT) evaluation, and Schirmer’s test. Dry eye symptoms were evaluated with the Dry Eye-related Quality-of-Life Score (DEQS) questionnaire. Lid-margin abnormalities, meibum grade, and meiboscores were assessed using meibography. Clinical activity scores and T2 signal intensity ratios were used to define GO activity. All GO patients had obstructive MGD and 79% exhibited levator muscle enlargement. Ocular surface parameters of TBUT (p = 0.000), meibum score (p = 0.000), eyelid vasculitis (p = 0.000), meiboscore of the upper lid (p = 0.002), total meiboscores (p = 0.001), and DEQS (p = 0.000) significantly differed between GO patients and normal subjects. In addition, GO patients had significantly more abnormalities of the central region of the upper eyelid than normal subjects (p = 0.000). Thus, MGD might be related to eye discomfort and deterioration of the ocular surface in GO patients. Inflammation and morphological meibomian gland changes might be characteristic of GO.

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Autoimmune Dry Eye without Significant Ocular Surface Co-Morbidities and Mental Health

Vision ◽

10.3390/vision4040043 ◽

2020 ◽

Vol 4 (4) ◽

pp. 43

Author(s):

Zahra Ashena ◽

Radhika Dashputra ◽

Mayank A. Nanavaty

Keyword(s):

Mental Health ◽

Dry Eye ◽

Ocular Surface ◽

Tear Film ◽

Management Plan ◽

Depression And Anxiety ◽

Related Quality ◽

Health Related ◽

Eye Symptoms ◽

Dry Eye Symptoms

Dry eye symptoms can negatively affect the psychological, physical, and social functioning, which can potentially impair the health-related quality of life. This review evaluated the association between autoimmune related dry eye in the absence of significant ocular surface co-morbidities and mental health. This review found a significantly higher prevalence of mental health disorders (such as depression and anxiety) in systemic lupus erythematous, rheumatoid arthritis, systemic sclerosis, Behcet’s disease, and primary Sjogren’s syndrome patients when compared to the general population. Moreover, patients with depression and anxiety interpret ocular sensations differently than healthy controls and the perception of dry eye symptoms can be influenced by their mood. Somatization is common in depression, and this could influence the perception of ocular discomfort. Anti-depressants and anxiolytics with their potential side effects on the tear film status may also contribute or aggravate the dry eye symptoms in these patients. Although ophthalmologists manage the dry eye disease, as per standardized algorithms, they should be mindful of different ocular sensation interpretation and coexistent mental health issues in a large number of this patient group and initiate a multidisciplinary management plan in certain cases. While rheumatologists look after their autoimmune condition, it may be worth liaising with GP and/or psychiatrist colleagues in order to address their neuropathic type pain and mental health co-morbidities.

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In vivo detection of clinically non-apparent ocular surface inflammation in patients with meibomian gland dysfunction-associated refractory dry eye symptoms: a pilot study

Eye ◽

10.1038/eye.2015.103 ◽

2015 ◽

Vol 29 (8) ◽

pp. 1099-1110 ◽

Cited By ~ 15

Author(s):

Y Qazi ◽

A Kheirkhah ◽

C Blackie ◽

A Cruzat ◽

M Trinidad ◽

...

Keyword(s):

Pilot Study ◽

Dry Eye ◽

Ocular Surface ◽

Meibomian Gland ◽

In Vivo Detection ◽

Eye Symptoms ◽

Surface Inflammation ◽

Ocular Surface Inflammation ◽

Dry Eye Symptoms

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Prevalence and Risk Factors of Severe Dry Eye in Bangladesh-Based Factory Garment Workers

Diagnostics ◽

10.3390/diagnostics10090634 ◽

2020 ◽

Vol 10 (9) ◽

pp. 634 ◽

Cited By ~ 1

Author(s):

Mamunur AKM Rashid ◽

Calesta Hui Yi Teo ◽

Sumaiya Mamun ◽

Hon Shing Ong ◽

Louis Tong

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Age Groups ◽

Meibomian Gland ◽

Ocular Surface Disease Index ◽

Cross Sectional ◽

Garment Workers ◽

Severity Grading ◽

Eye Symptoms ◽

Dry Eye Symptoms

This study sought to evaluate the prevalence of dry eye and meibomian gland dysfunction (MGD) and the associated factors of severe dry eye symptoms (SDES) among garments worker of Gazipur, Bangladesh. We prospectively collected cross-sectional data for 1050 garments workers of a factory (70% response). All participants had an evaluation of the Ocular Surface Disease Index (OSDI), and a detailed ophthalmic examination including tear breakup time (TBUT), ocular surface fluorescein staining, and Schirmer’s I test. MGD grading was based on the viscosity/color and ease of manual expression of meibum. Mean age of participants was 35.5 ± 12.1 years; 53.8% were women. The prevalence of dry eye (OSDI > 12) was 64.2% (95% CI 61.2–67.1%). OSDI was not significantly different between sex or age-groups but associated with increasing MGD grade (p < 0.001), reduced TBUT (<5 s) [p < 0.001], and reduced Schirmer’s test (<5 mm) [p < 0.001]. Thirty-five percent had SDES (OSDI > 32). Using univariate logistic regressions, SDES was associated with older age (Odds Ratio (OR) 1.01, 95% Confidence Interval [1.005–1.03] per year increase) and male sex (OR 1.76, 95% CI: 1.36–2.27). When adjusted for age and sex, SDES were strongly associated with increase in MGD severity grading (OR 188, 95% CI: 91–390). However, in multivariate regression, TBUT, but not MGD severity, became the only significant determinant of SDES (OR 13.0, 95% CI: 6.3–27.0, for every 1 s decrease in TBUT). MGD is common in garments workers, contributing to dry eye symptoms in addition to other tear parameters. Reduced tear stability is associated with SDES.

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Optimum | Tangible Hydra-PEG™ – Gaining Momentum in the Industry

The Eye ◽

10.33791/2222-4408-2021-4-31-34 ◽

2021 ◽

Vol 23 (4) ◽

pp. 31-34

Author(s):

M. Conway

Keyword(s):

Dry Eye ◽

Ocular Surface ◽

Surface Coating ◽

Clinical Case ◽

Contact Lenses ◽

Ocular Surface Disease ◽

Corneal Ectasia ◽

Corneal Lens ◽

Eye Symptoms ◽

Dry Eye Symptoms

The issue of hydrophilicity of the surface of gas permeable contact lenses remains one of the persistent problems. Tangible Hydra-PEG™ surface coating is applied to gas permeable contact lenses to significantly improve wettability and wearing comfort. Although it is mainly used to alleviate dry eye symptoms in scleral and corneal lens users, particularly for those patients with corneal ectasia and/or Ocular Surface Disease (OSD), it can be used in other modalities. This article describes the development of the product and describes the benefits of its use in a clinical case.

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TEAR FILM EVALUATION IN CASES OF PARKINSON’S DISEASE

10.36106/ijar/8503716 ◽

2021 ◽

pp. 22-24

Author(s):

V. Meenakshi ◽

Saswathi Bhushan ◽

T. Jyothirmayi

Keyword(s):

Parkinson’S Disease ◽

Parkinson's Disease ◽

Dry Eye ◽

Meibomian Gland ◽

Blink Rate ◽

Eye Symptoms ◽

Tear Meniscus ◽

Tear Meniscus Height ◽

Dry Eye Symptoms ◽

Meibomian Gland Disease

AIM: To evaluate tear lm status in cases of Parkinson's Disease and compare with a study group METHODS:50 patients of Parkinson's Disease and 50 age-gender matched controls were included in this study. Both groups underwent detailed history regarding dry eye symptoms,tear lm evaluation using slit-lamp bio-microscopy, uorescein staining, tear meniscus height, tear breakup time, Schirmer test, blink rate. Statistical analysis was done with Statistical Package for Social Sciences [SPSS] - Version 22.0 Released 2013 version RESULTS: There was a signicant difference between the various groups in terms of distribution of Meibomian Gland Disease 72.0% of the Case group as compared to 40% of control group had Meibomian Gland Disease,There was a signicant difference between the various groups in terms of distribution of Tear Meniscus Height <0.25Mm , Case group had the larger proportion of Tear Meniscus Height of <0.25Mm .There was a signicant difference between the various groups in terms of distribution of Tear Breakup Time <5 Sec, Schirmer's Test <5Mm in 5Min and Blink Rate <10 .There was no signicant difference between the various groups in terms of distribution of corneal Staining and dry eye symptoms. CONCLUSION: The study concluded that patient of Parkinson's disease had higher dry eye symptoms and Meibomian gland disease Also they have reduced Tear miniscus height,Tear lm break up time,Schirmer test I and Blink rate

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