scholarly journals Hybrid PET–MRI Imaging in Paediatric and TYA Brain Tumours: Clinical Applications and Challenges

2020 ◽  
Vol 10 (4) ◽  
pp. 218
Author(s):  
Ananth Shankar ◽  
Jamshed Bomanji ◽  
Harpreet Hyare
Keyword(s):  
Brain Tumours ◽  
Therapeutic Assessment ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Single Centre ◽  
Positron Emission ◽  
Early Treatment Response ◽  
Single Centre Experience ◽  
Magnetic Resonance Imaging Mri ◽  
Standard Magnetic Resonance Imaging

(1) Background: Standard magnetic resonance imaging (MRI) remains the gold standard for brain tumour imaging in paediatric and teenage and young adult (TYA) patients. Combining positron emission tomography (PET) with MRI offers an opportunity to improve diagnostic accuracy. (2) Method: Our single-centre experience of 18F-fluorocholine (FCho) and 18fluoro-L-phenylalanine (FDOPA) PET–MRI in paediatric/TYA neuro-oncology patients is presented. (3) Results: Hybrid PET–MRI shows promise in the evaluation of gliomas and germ cell tumours in (i) assessing early treatment response and (ii) discriminating tumour from treatment-related changes. (4) Conclusions: Combined PET–MRI shows promise for improved diagnostic and therapeutic assessment in paediatric and TYA brain tumours.

scholarly journals A positron-emission tomography (PET)/magnetic resonance imaging (MRI) platform to track in vivo small extracellular vesicles

Nanoscale ◽  
2019 ◽  
Vol 11 (28) ◽  
pp. 13243-13248 ◽  
Author(s):  
Arnab Banerjee ◽  
Vitor Alves ◽  
Tiago Rondão ◽  
José Sereno ◽  
Ângela Neves ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Mri Imaging ◽  
Resonance Imaging ◽  
Receptor Proteins ◽  
Positron Emission ◽  
Surface Receptor ◽  
Magnetic Resonance Imaging Mri

A new radiolabeling strategy which did not change the morphology, surface receptor proteins and internal RNA content of SEVs used for PET/MRI imaging and detection of their location in brain.

scholarly journals Shape matters: morphological metrics of glioblastoma imaging abnormalities as biomarkers of prognosis

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lee Curtin ◽  
Paula Whitmire ◽  
Haylye White ◽  
Kamila M. Bond ◽  
Maciej M. Mrugala ◽  
...  
Keyword(s):  
Fractal Dimension ◽  
Tumor Location ◽  
Primary Brain Tumor ◽  
Resonance Imaging ◽  
Significant Relationships ◽  
Biological Phenomena ◽  
Microenvironmental Factors ◽  
Magnetic Resonance Imaging Mri ◽  
The Relationship ◽  
Standard Magnetic Resonance Imaging

AbstractLacunarity, a quantitative morphological measure of how shapes fill space, and fractal dimension, a morphological measure of the complexity of pixel arrangement, have shown relationships with outcome across a variety of cancers. However, the application of these metrics to glioblastoma (GBM), a very aggressive primary brain tumor, has not been fully explored. In this project, we computed lacunarity and fractal dimension values for GBM-induced abnormalities on clinically standard magnetic resonance imaging (MRI). In our patient cohort (n = 402), we connect these morphological metrics calculated on pretreatment MRI with the survival of patients with GBM. We calculated lacunarity and fractal dimension on necrotic regions (n = 390), all abnormalities present on T1Gd MRI (n = 402), and abnormalities present on T2/FLAIR MRI (n = 257). We also explored the relationship between these metrics and age at diagnosis, as well as abnormality volume. We found statistically significant relationships to outcome for all three imaging regions that we tested, with the shape of T2/FLAIR abnormalities that are typically associated with edema showing the strongest relationship with overall survival. This link between morphological and survival metrics could be driven by underlying biological phenomena, tumor location or microenvironmental factors that should be further explored.

scholarly journals Metal-Based Complexes as Pharmaceuticals for Molecular Imaging of the Liver

2019 ◽  
Vol 12 (3) ◽  
pp. 137 ◽  
Author(s):  
Julia Greiser ◽  
Wolfgang Weigand ◽  
Martin Freesmeyer
Keyword(s):  
Magnetic Resonance Imaging ◽  
Positron Emission Tomography ◽  
Metal Complexes ◽  
Imaging Technique ◽  
Imaging Modality ◽  
Emission Tomography ◽  
Resonance Imaging ◽  
Positron Emission ◽  
Magnetic Resonance Imaging Mri ◽  
Uptake Mechanisms

This article reviews the use of metal complexes as contrast agents (CA) and radiopharmaceuticals for the anatomical and functional imaging of the liver. The main focus was on two established imaging modalities: magnetic resonance imaging (MRI) and nuclear medicine, the latter including scintigraphy and positron emission tomography (PET). The review provides an overview on approved pharmaceuticals like Gd-based CA and 99mTc-based radiometal complexes, and also on novel agents such as 68Ga-based PET tracers. Metal complexes are presented by their imaging modality, with subsections focusing on their structure and mode of action. Uptake mechanisms, metabolism, and specificity are presented, in context with advantages and limitations of the diagnostic application and taking into account the respective imaging technique.

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