scholarly journals An Investigation on Spray-Granulated, Macroporous, Bioactive Glass Microspheres for a Controlled Drug Delivery System

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 3112
Author(s):  
Henni Setia Ningsih ◽  
Liu-Gu Chen ◽  
Ren-Jei Chung ◽  
Yu-Jen Chou
Keyword(s):  
Drug Release ◽  
Bioactive Glass ◽  
Particle Morphology ◽  
Nitrogen Adsorption ◽  
Drug Carriers ◽  
In Vitro Drug Release ◽  
Controlled Drug Delivery System ◽  
Excellent Candidate ◽  
Adsorption Desorption

Bioactive glass (BG) has been regarded as an excellent candidate for biomedical applications due to its superior properties of bioactivity, biocompatibility, osteoconductivity and biodegradability. Thus, in this study, we aimed to fabricate drug carriers that were capable of loading therapeutic antibiotics while promoting bone regeneration using macroporous BG microspheres, prepared by a spray drying method. Characterizations of particle morphology and specific surface area were carried out via scanning electron microscopy and nitrogen adsorption/desorption isotherm. Evaluations of in vitro bioactivity were performed based on Kokubo’s simulated body fluid to confirm the formation of the hydroxyapatite (HA) layer after immersion. In addition, the in vitro drug release behaviors were examined, using tetracycline as the therapeutic antibiotic in pH 7.4 and 5.0 environments. Finally, the results showed that BG microspheres of up to 33 μm could be mass-produced, targeting various therapeutic situations and their resulting bioactivities and drug release behaviors, and related properties were discussed.

scholarly journals Formulation And Characterization of Carageenan Gels Encapsulating Amphotericin B And Lactobacillus acidophilus Against Candidal Vaginitis

2017 ◽  
Vol 4 (1) ◽  
pp. 37-49
Author(s):  
R Kaur ◽  
M Khurana ◽  
M Bindal ◽  
A Sharma
Keyword(s):  
Candida Albicans ◽  
Drug Release ◽  
Sustained Release ◽  
Amphotericin B ◽  
Lactobacillus Acidophilus ◽  
Drug Carriers ◽  
In Vitro Drug Release ◽  
Antimicrobial Studies

The present study is concerned with the development and characterization of bioadhesive carageenan gel encapsulating Amphotericin B and Lactobacillus acidophillus, prepared by graft co-polymeriztion against Candidal vaginitis. Intravaginal gel systems based on bioadhesive polymer (carrageenan) were characterized with respect to swelling index, bioadhesive strength, percent encapsulation and in vitro drug release antimicrobial studies. A marked increase in swelling index of gel encapsulating Lactobacillus was found to be 1.9±0.35. The percent encapsulation of drug was found to be 98.63%±.0.2% and that of Lactobacillus was 91.81 ±0.01. The viability was observed for interval of 6 hrs on trypton soya agar and showed that viability was highly conserved till 4 hrs. The antimicrobial study of gels encapsulating Amphotericin B and Lactobacillus showed that carageenan gel can inhibit Candida albicans upto a maximum extent. Bioadhesivity study also conducted for gels that showed a bioadhesivity of 84.66% ±.0.5% with drug, 88.66% ±.02% with Lactobacillus. In-vitro drug release showed a sustained type release of drug from the polymer i.e. there was initial burst of Amphotericin B up to 5 hours, after which there was a sustained release upto 10 days. Thus it has been concluded from the present study that bioadhesive gels encapsulating Amphotericin B can act as promising drug carriers along with Lactobacillus against candidal vaginitis.

scholarly journals Modulatinn Intestinal Uptake of Atenolol Usinn Niosomes as Drun Permeation Enhancers

2005 ◽  
Vol 73 (3) ◽  
pp. 81-93 ◽  
Author(s):  
lbrahim Alsarra ◽  
Ahmed Bosela ◽  
Abdullah M. Al-Mohizea ◽  
Gamal M. Mahrous ◽  
Steven H. Neau
Keyword(s):  
Drug Release ◽  
Release Kinetics ◽  
Drug Carriers ◽  
Enhancement Effect ◽  
In Vitro Drug Release ◽  
Vesicle Size ◽  
Drug Permeation ◽  
Intestinal Membrane ◽  
Conventional Film

It is well established through the last decade that niosomes have potential applications as drug carriers either to improve drug permeation across membranes or targeting to specific tissues. Having a considerable ability to improve the permeability of drugs through lipoid membranes, niosomes have been utilized as carriers to enhance atenolol absorption from the gastrointestinal tract. Two methods have been adopted to prepare niosomes, the proniosome-derived method (A) and the conventional film hydration method (B). The products from the two methods were compared in terms of their morphology, vesicle size, drug encapsulation efficiency, in vitro drug release and enhancement effect on drug permeation across the intestinal membrane using an everted sac technique. Proniosome-derived niosomes were smoother and exhibited a smaller (5 μm) vesicle size compared to those prepared by conventional methods (12 μm). High encapsulation efficiencies of 98.6% and 93.4% were achieved by methods A and B, respectively. In vitro drug release has been significantly retarded from both types of niosomes. Comparing to pure drug, which dissolved completely in 15 min, only 8.9% and 9.9% of the entrapped drug was released in the same time period. The drug release kinetics showed non-Fickian (anomalous) behavior. Permeation through an everted intestinal sac showed a significant enhancement effect (more than 4 fold) for both types of niosomes compared to untrapped drug; however, the difference between the two types of niosomes was not significant

scholarly journals Correlation of Morphology and In-Vitro Degradation Behavior of Spray Pyrolyzed Bioactive Glasses

Materials ◽  
2019 ◽  
Vol 12 (22) ◽  
pp. 3703 ◽  
Author(s):  
Fetene Fufa Bakare ◽  
Yu-Jen Chou ◽  
Yu-Hsuan Huang ◽  
Abadi Hadush Tesfay ◽  
Toshihiro Moriga ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Particle Morphology ◽  
Nitrogen Adsorption ◽  
Bone Tissue Regeneration ◽  
Degradation Behavior ◽  
Surface Areas ◽  
Transmission Electron ◽  
Spray Pyrolysis Process ◽  
Adsorption Desorption

Bioactive glass (BG) is considered to be one of the most remarkable materials in the field of bone tissue regeneration due to its superior bioactivity. In this study, both un-treated and polyethylene glycols (PEG)-treated BG particles were prepared using a spray pyrolysis process to study the correlation between particle morphology and degradation behavior. The phase compositions, surface morphologies, inner structures, and specific surface areas of all BG specimens were examined by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and nitrogen adsorption/desorption, respectively. Simulated body fluid (SBF) immersion evaluated the assessments of bioactivity and degradation behavior. The results demonstrate three particle morphologies of solid, porous, and hollow factors. The correlation between porosity, bioactivity, and degradation behavior was discussed.

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