scholarly journals Comparison of Hydroxypropylcellulose and Hot-Melt Extrudable Hypromellose in Twin-Screw Melt Granulation of Metformin Hydrochloride: Effect of Rheological Properties of Polymer on Melt Granulation and Granule Properties

Macromol ◽  
2021 ◽  
Vol 2 (1) ◽  
pp. 1-19
Author(s):  
Amol Batra ◽  
Fengyuan Yang ◽  
Michael Kogan ◽  
Anthony Sosnowik ◽  
Courtney Usher ◽  
...  
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Low Temperatures ◽  
Extended Release ◽  
Metformin Hydrochloride ◽  
Drug Degradation ◽  
Twin Screw ◽  
Hot Melt ◽  
Melt Granulation ◽  
Metformin Hcl

High-molecular-weight hypromellose (HPMC) and hydroxypropyl cellulose (HPC) are widely known, extended-release polymers. Conventional high-molecular-weight HPMCs are preferred in extended-release applications but not widely used in twin-screw melt granulation due to processability difficulties at low operating temperatures and potential drug degradation if high processing temperatures are used. Conversely, high-molecular-weight grade HPC (Klucel®) can be used in melt granulation processes. The purpose of this study was to evaluate the processability and dissolution behavior of HPC GXF ((Klucel® GXF) and a recently introduced type of hot-melt extrudable HPMC (Affinisol®) in extended-release metformin hydrochloride formulations using twin-screw melt granulation. Powder blends were prepared with 75% w/w metformin HCl and 25% w/w polymeric binder. Blends were granulated at processing temperatures of 160, 140, 120 and 100 °C. HPMC HME 4M (Affinisol® 4M) provided a fine powder, indicating minimum granulation at processing temperatures lower than 160 °C, and the tablets obtained with these granules capped during tableting. In contrast, acceptable tablets could be obtained with HPC GXF at all processing temperatures. Rheological studies including capillary rheometry to measure steady shear rate viscosity, and rotational rheometry to obtain time and temperature superposition data, showed that HPC GXF had a greater thermoplasticity than HPMC HME 4M, which made granulation possible with HPC GXF at low temperatures. Tablets compressed with granules obtained at 160 °C with both binders showed comparable dissolution profiles. High-molecular-weight HPC GXF provided a better processability at low temperatures and adequate tablet strength for the melt granulation of metformin HCl.

scholarly journals Stearic acid and high molecular weight PEO as matrix for the highly water soluble metoprolol tartrate in continuous twin-screw melt granulation

2016 ◽  
Vol 512 (1) ◽  
pp. 158-167 ◽  
Author(s):  
Tinne Monteyne ◽  
Peter Adriaensens ◽  
Davinia Brouckaert ◽  
Jean-Paul Remon ◽  
Chris Vervaet ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Stearic Acid ◽  
High Molecular Weight ◽  
Water Soluble ◽  
Metoprolol Tartrate ◽  
Twin Screw ◽  
Melt Granulation

scholarly journals Synergistic toughening of polypropylene with ultra-high molecular weight polyethylene and elastomer-olefin block copolymers

RSC Advances ◽  
2019 ◽  
Vol 9 (41) ◽  
pp. 23994-24002 ◽  
Author(s):  
Lucheng Qi ◽  
Lei Wu ◽  
Ren He ◽  
Hui Cheng ◽  
Boping Liu ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Block Copolymers ◽  
Rheological Properties ◽  
High Molecular Weight ◽  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Twin Screw ◽  
Ultra High Molecular Weight

Blends of polypropylene (PP) and ultra-high molecular weight polyethylene (UHMWPE) with elastomer-olefin block copolymers (OBC) were prepared using an ultrasonic twin-screw extruder, and their mechanical and rheological properties were investigated.

Increased total and high–molecular weight adiponectin after extended-release niacin

Metabolism ◽  
2008 ◽  
Vol 57 (3) ◽  
pp. 404-409 ◽  
Author(s):  
Eric P. Plaisance ◽  
Peter W. Grandjean ◽  
Brandon L. Brunson ◽  
Robert L. Judd
Keyword(s):  
Molecular Weight ◽  
High Molecular Weight ◽  
Extended Release ◽  
High Molecular Weight Adiponectin

Hot-Melt Granulation in a Twin Screw Extruder: Effects of Processing on Formulations with Caffeine and Ibuprofen

2013 ◽  
Vol 102 (12) ◽  
pp. 4330-4336 ◽  
Author(s):  
Sharleen Weatherley ◽  
B.O. MU ◽  
Michael R. Thompson ◽  
Paul J. Sheskey ◽  
Kevin P. O'Donnell
Keyword(s):  
Twin Screw Extruder ◽  
Screw Extruder ◽  
Twin Screw ◽  
Hot Melt Granulation ◽  
Hot Melt ◽  
Melt Granulation

Ultra-high molecular weight polyethylene fiber-reinforced thermoplastic corn starch composite

2016 ◽  
Vol 30 (4) ◽  
pp. 564-577 ◽  
Author(s):  
Bin Guo ◽  
Li-Jian Wang ◽  
Peng Yin ◽  
Ben-Gang Li ◽  
Pan-Xin Li
Keyword(s):  
Molecular Weight ◽  
Contact Angle ◽  
High Molecular Weight ◽  
Corn Starch ◽  
Thermoplastic Starch ◽  
Polyethylene Fiber ◽  
Twin Screw ◽  
Uhmwpe Fibers ◽  
Fibrous Morphology ◽  
Ultra High Molecular Weight

The ultra-high molecular weight polyethylene (UHMWPE) fibers, as the fibrous morphology of polyethylene (PE), were first used to reinforce thermoplastic starch (TPS) by a twin screw extruder. The influence of the UHMWPE content on the mechanical and dynamic mechanical thermal properties, thermal stability, contact angle, torque rheological properties, and fractured surface morphology of the UHMWPE/TPS composites was studied in detail. We found that the UHMWPE fibers were well dispersed in the TPS matrix, and the mechanical properties and water resistance of the composites improved significantly. Especially, the incorporation of UHMWPE fibers at a content of 2 wt% generated a composite with better performance (tensile strength of 8.78 MPa and contact angle of 80.2°).

I.—The Future of Synthetic Plastics

1944 ◽  
Vol 62 (1) ◽  
pp. 1-9
Author(s):  
H. W. Melville
Keyword(s):  
Mechanical Properties ◽  
Molecular Weight ◽  
High Molecular Weight ◽  
Mass Production ◽  
Low Temperatures ◽  
The Other ◽  
New Materials ◽  
Production Methods ◽  
Chemical Theory ◽  
Chemical Constitution

The term synthetic plastic covers such a wide variety of substances that it is an extremely difficult matter to attempt a definition—nor is it necessary for the purpose of this review. To the chemist plastics are solids of high molecular weight exhibiting properties which lie between those of liquids and solids: at sufficiently high temperatures they behave like liquids and at low temperatures like solids. These substances do not obey many of the laws which form the corner-stones of chemical theory, for their chemical constitution can be varied by indefinitely small degrees and it is possible mechanically to divide the molecule into parts. To the layman, on the other hand, plastics have come to mean substances used to fabricate, by mass-production methods, relatively trivial articles like ashtrays, ornamental door-knobs, etc. They tend to be regarded as substitutes which must necessarily be inferior to the materials, once used to make these domestic articles. Much, too, has been written to give the impression that we are on the verge of the plastics era. This is an optimistic exaggeration. Plastics are designed to play an important part as unique materials which can be built by the chemist to the specification of the engineer and the physicist. It is wrong to regard them as substitutes. They are new materials and must be used as such. The purpose of this survey is to indicate how synthetic plastics fit into a future economy in which their special chemical and mechanical properties find their proper application.

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