scholarly journals Adaptive Control of CO2 Production during Milk Fermentation in a Batch Bioreactor

Mathematics ◽  
2021 ◽  
Vol 9 (15) ◽  
pp. 1712
Author(s):  
Jožef Ritonja

The basic characteristic of batch bioreactors is their inability to inflow or outflow the substances during the fermentation process. This follows in the simple construction and maintenance, which is the significant advantage of batch bioreactors. Unfortunately, this characteristic also results in the inability of the current industrial and laboratory batch bioreactors to control fermentation production during the process duration. In some recent studies, it was shown that changing the temperature could influence the execution of the fermentation process. The presented paper shows that this phenomenon could be used to develop the closed-loop control system for the fermentation production control in batch bioreactors. First, based on theoretical work, experiments, and numerical methods, the appropriate structure of the mathematical model was determined and parameters were identified. Next, the closed-loop control system structure for batch bioreactor was proposed, and the linear and adaptive control system based on this structure and the derived and identified model were developed. Both modeling and adaptive control system design are new and represent original contributions. As expected, due to the non-linearity of the controlled plant, the adaptive control represents a more successful approach. The simulation and experimental results were used to confirm the applicability of the proposed solution.

2020 ◽  
Vol 11 (1) ◽  
pp. 84
Author(s):  
Jožef Ritonja ◽  
Andreja Goršek ◽  
Darja Pečar

Fermentation is a crucial bioengineering process, existentially important for modern society. The most commonly used production unit for this process is the batch bioreactor. Its main advantage is unsophisticated construction, which unfortunately results in its incapability of controlling the transient state of the fermentation process. Control of the fermentation can significantly improve the quality of the product and the economy of the process; therefore, it is useful for bioreactors to be equipped with a control system. Based on the experimental results, we used an optimization method to identify a mathematical model that describes the impact of the bioreactor’s temperature on the fermentation’s transient process. The obtained model was applied for the design and synthesis of the closed-loop control system. Simulations and experiments confirmed the effectiveness of the proposed control system. In this way, we can ensure the consistent quality of the produced probiotic product, increase the amount of the product, and shorten the fermentation time. The original results display the feasibility of the closed-loop control of the batch bioreactor’s fermentation process by changing the temperature. So far, the process has been carried without a closed-loop control system. The problem is current and has not yet been solved sufficiently. There are many attempts published; one of the last shows the possibility of controlling the fermentation process by changing the oxygen supply, which is more complex and expensive for realization than the solution from our study.


2017 ◽  
Vol 3 (2) ◽  
pp. 363-366
Author(s):  
Tobias Steege ◽  
Mathias Busek ◽  
Stefan Grünzner ◽  
Andrés Fabían Lasagni ◽  
Frank Sonntag

AbstractTo improve cell vitality, sufficient oxygen supply is an important factor. A deficiency in oxygen is called Hypoxia and can influence for example tumor growth or inflammatory processes. Hypoxia assays are usually performed with the help of animal or static human cell culture models. The main disadvantage of these methods is that the results are hardly transferable to the human physiology. Microfluidic 3D cell cultivation systems for perfused hypoxia assays may overcome this issue since they can mimic the in-vivo situation in the human body much better. Such a Hypoxia-on-a-Chip system was recently developed. The chip system consists of several individually laser-structured layers which are bonded using a hot press or chemical treatment. Oxygen sensing spots are integrated into the system which can be monitored continuously with an optical sensor by means of fluorescence lifetime detection.Hereby presented is the developed hard- and software requiered to control the oxygen content within this microfluidic system. This system forms a closed-loop control system which is parameterized and evaluated.


Author(s):  
Bahram Yaghooti ◽  
Ali Siahi Shadbad ◽  
Kaveh Safavi ◽  
Hassan Salarieh

In this article, an adaptive nonlinear controller is designed to synchronize two uncertain fractional-order chaotic systems using fractional-order sliding mode control. The controller structure and adaptation laws are chosen such that asymptotic stability of the closed-loop control system is guaranteed. The adaptation laws are being calculated from a proper sliding surface using the Lyapunov stability theory. This method guarantees the closed-loop control system robustness against the system uncertainties and external disturbances. Eventually, the presented method is used to synchronize two fractional-order gyro and Duffing systems, and the numerical simulation results demonstrate the effectiveness of this method.


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