scholarly journals Marine Natural Products: Promising Candidates in the Modulation of Gut-Brain Axis towards Neuroprotection

Marine Drugs ◽  
2021 ◽  
Vol 19 (3) ◽  
pp. 165
Author(s):  
Sajad Fakhri ◽  
Akram Yarmohammadi ◽  
Mostafa Yarmohammadi ◽  
Mohammad Hosein Farzaei ◽  
Javier Echeverria
Keyword(s):  
Natural Products ◽  
Neurodegenerative Diseases ◽  
Marine Natural Products ◽  
Neurological Diseases ◽  
Point Of View ◽  
The Road ◽  
Bidirectional Regulation ◽  
Bidirectional Relationship ◽  
Macrolactin A ◽  
Stress Mediators

In recent decades, several neuroprotective agents have been provided in combating neuronal dysfunctions; however, no effective treatment has been found towards the complete eradication of neurodegenerative diseases. From the pathophysiological point of view, growing studies are indicating a bidirectional relationship between gut and brain termed gut-brain axis in the context of health/disease. Revealing the gut-brain axis has survived new hopes in the prevention, management, and treatment of neurodegenerative diseases. Accordingly, introducing novel alternative therapies in regulating the gut-brain axis seems to be an emerging concept to pave the road in fighting neurodegenerative diseases. Growing studies have developed marine-derived natural products as hopeful candidates in a simultaneous targeting of gut-brain dysregulated mediators towards neuroprotection. Of marine natural products, carotenoids (e.g., fucoxanthin, and astaxanthin), phytosterols (e.g., fucosterol), polysaccharides (e.g., fucoidan, chitosan, alginate, and laminarin), macrolactins (e.g., macrolactin A), diterpenes (e.g., lobocrasol, excavatolide B, and crassumol E) and sesquiterpenes (e.g., zonarol) have shown to be promising candidates in modulating gut-brain axis. The aforementioned marine natural products are potential regulators of inflammatory, apoptotic, and oxidative stress mediators towards a bidirectional regulation of the gut-brain axis. The present study aims at describing the gut-brain axis, the importance of gut microbiota in neurological diseases, as well as the modulatory role of marine natural products towards neuroprotection.

scholarly journals Natural Products in Neurodegenerative Diseases: A Great Promise but an Ethical Challenge

2019 ◽  
Vol 20 (20) ◽  
pp. 5170 ◽  
Author(s):  
Marco Di Paolo ◽  
Luigi Papi ◽  
Federica Gori ◽  
Emanuela Turillazzi
Keyword(s):  
Natural Products ◽  
Patient Safety ◽  
Neurodegenerative Diseases ◽  
The Elderly ◽  
Biomedical Ethics ◽  
Point Of View ◽  
Ethical Framework ◽  
Ethical Challenge ◽  
Great Promise ◽  
Mortality And Morbidity

Neurodegenerative diseases (NDs) represent one of the most important public health problems and concerns, as they are a growing cause of mortality and morbidity worldwide, particularly in the elderly. Despite remarkable breakthroughs in our understanding of NDs, there has been little success in developing effective therapies. The use of natural products may offer great potential opportunities in the prevention and therapy of NDs; however, many clinical concerns have arisen regarding their use, mainly focusing on the lack of scientific support or evidence for their efficacy and patient safety. These clinical uncertainties raise critical questions from a bioethical and legal point of view, as considerations relating to patient decisional autonomy, patient safety, and beneficial or non-beneficial care may need to be addressed. This paper does not intend to advocate for or against the use of natural products, but to analyze the ethical framework of their use, with particular attention paid to the principles of biomedical ethics. In conclusion, the notable message that emerges is that natural products may represent a great promise for the treatment of many NDs, even if many unknown issues regarding the efficacy and safety of many natural products still remain.

scholarly journals Synthetic efforts on the road to marine natural products bearing 4-O-2,3,4,6-tetrasubstituted THPs: an update

RSC Advances ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 5832-5858
Author(s):  
Marta Fariña-Ramos ◽  
Celina García ◽  
Víctor S. Martín ◽  
Sergio J. Álvarez-Méndez
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
The Road ◽  
Lasonolide A ◽  
Marine Macrolides ◽  
Polycavernoside A ◽  
On The Road

A review covering the synthetic efforts directed to miyakolide, polycavernoside A, lasonolide A, clavosolide A and madeirolide A. They belong to the unique families of marine macrolides bearing 4-O-2,3,4,6 tetrasubstituted THPs.

scholarly journals A Minireview on Biodiscovery in Antarctic Marine Benthic Invertebrates

2021 ◽  
Vol 8 ◽  
Author(s):  
Conxita Avila ◽  
Carlos Angulo-Preckler
Keyword(s):  
Natural Products ◽  
Neurodegenerative Diseases ◽  
Benthic Invertebrates ◽  
Marine Natural Products ◽  
Antimicrobial Activities ◽  
Supply Problem ◽  
Antarctic Marine ◽  
Marine Benthic Invertebrates ◽  
Near Future ◽  
Potential Use

Antarctic marine benthic invertebrates are an underexplored source of natural products for biodiscovery. Bioactive marine natural products from Antarctica are reviewed here for their potential use as drugs, considering the main examples in Porifera (15 species), Cnidaria (eight species), Mollusca (one species), Bryozoa (one species), Nemertea (one species), Echinodermata (six species), and Tunicata (five species). A wide variety of bioactivities are reported here, from antitumoral to antimicrobial activities, as well as against neurodegenerative diseases and others. If we aim to use their chemodiversity for human benefits we must maintain the biodiversity, solving the supply problem, speeding up the process, and decreasing research costs to fully exploit the benefits of biodiscovery in Antarctic Marine Natural Products in a near future in a sustainable way.

The discoipyrroles: A multifaceted approach to understand a novel family of marine natural products

Planta Medica ◽  
2015 ◽  
Vol 81 (11) ◽  
Author(s):  
DA Colosimo ◽  
F Cai ◽  
Y Hu ◽  
MB Potts ◽  
MA White ◽  
...  
Keyword(s):  
Natural Products ◽  
Marine Natural Products ◽  
Multifaceted Approach

Synthesis of Marine Natural Products 1

1992 ◽  
Author(s):  
K. F. Albizati ◽  
V. A. Martin ◽  
M. R. Agharahimi ◽  
D. A. Stolze
Keyword(s):  
Natural Products ◽  
Marine Natural Products

Synthesis and Biological Evaluation of the Antimicrobial Natural Product Lipoxazolidinone A

2018 ◽  
Author(s):  
Jonathan J. Mills ◽  
Kaylib R. Robinson ◽  
Troy E. Zehnder ◽  
Joshua G. Pierce
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
Mechanism Of Action ◽  
Marine Natural Products ◽  
Biological Evaluation ◽  
Lead Compounds ◽  
Follow Up Studies ◽  
Initial Resistance ◽  
Synthesis And Biological Evaluation

The lipoxazolidinone family of marine natural products, with an unusual 4-oxazolidinone heterocycle at their core, represents a new scaffold for antimicrobial discovery; however, questions regarding their mechanism of action and high lipophilicity have likely slowed follow-up studies. Herein, we report the first synthesis of lipoxazolidinone A, 15 structural analogs to explore its active pharmacophore, and initial resistance and mechanism of action studies. These results suggest that 4-oxazolidinones are valuable scaffolds for antimicrobial development and reveal simplified lead compounds for further optimization.

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