Sarcoma as Second Cancer in a Childhood Cancer Survivor: Case Report, Large Population Analysis and Literature Review

The majority of pediatric patients are cured of their primary cancer with current advanced developments in pediatric cancer therapy. However, survivors often experience long-term complications from therapies for primary cancer. The delayed mortality rate has been decreasing with the effort to reduce the therapeutic exposure of patients with pediatric cancers. Our study investigates the incidence of sarcoma as second cancer in pediatric cancer survivors. We present a 9-year-old male who survived embryonal hepatoblastoma diagnosed at 22 months of age. At 4.5 years of age, he presented with a non-metastatic primitive neuroectodermal tumor (PNET) of the left submandibular area. He has no evidence of recurrence of either cancer for 51 months after finishing all chemotherapy and radiotherapy. We used the Surveillance, Epidemiology, and End Results (SEER) database to identify the current rate of second sarcomas in pediatric cancer survivors. Our literature review and large population analysis emphasize the impact of sarcoma as a second malignancy and provide help to physicians caring for pediatric cancer survivors.

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Abstract 2299: Sarcoma as second cancer in pediatric cancer survivors: Large population analysis

10.1158/1538-7445.am2020-2299 ◽

2020 ◽

Author(s):

Monish Ram Makena ◽

Thinh H. Nguyen ◽

Siddhartha Yavvari ◽

Maninder Kaur ◽

Teresia Pham ◽

...

Keyword(s):

Cancer Survivors ◽

Pediatric Cancer ◽

Population Analysis ◽

Large Population ◽

Second Cancer ◽

Pediatric Cancer Survivors

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Exercise cardiac MRI unmasks cardiac dysfunction in childhood and adolescent cancer survivors with reduced cardiopulmonary fitness

European Heart Journal ◽

10.1093/ehjci/ehaa946.3275 ◽

2020 ◽

Vol 41 (Supplement_2) ◽

Author(s):

S Foulkes ◽

B Costello ◽

E.J Howden ◽

K Janssens ◽

H Dillon ◽

...

Keyword(s):

Heart Failure ◽

Cardiac Function ◽

Cancer Survivors ◽

Pediatric Cancer ◽

Cardiac Dysfunction ◽

Cardiopulmonary Fitness ◽

Cardiac Reserve ◽

Pediatric Cancer Survivors ◽

Increased Risk

Abstract Background Young cancer survivors are at increased risk of impaired cardiopulmonary fitness (VO2peak) and heart failure. Assessment of exercise cardiac reserve may reveal sub-clinical abnormalities that better explain impairments in fitness and long term heart failure risk. Purpose To investigate the presence of impaired VO2peak in pediatric cancer survivors with increased risk of heart failure, and to assess its relationship with resting cardiac function and cardiac reserve Methods Twenty pediatric cancer survivors (aged 8–24 years) treated with anthracycline chemotherapy underwent cardiopulmonary exercise testing to quantify VO2peak, with a value <85% of predicted defined as impaired VO2peak. Resting cardiac function was assessed using 3-dimensional echocardiography, with cardiac reserve quantified from resting and peak exercise heart rate (HR), stroke volume index (SVi) and cardiac index (CI) using exercise cardiac magnetic resonance imaging. Results 12 of 20 survivors (60%) had impaired VO2peak (97±14% vs. 70±16% of age and gender predicted). There were no differences in echocardiographic or CMR measurements of resting cardiac function between survivors with normal or impaired VO2peak. However, those with reduced VO2peak had diminished cardiac reserve, with a lesser increase in CI (Fig. 1A) and SVi (Fig. 1B) during exercise (Interaction P=0.001 for both), whilst the HR response was similar (Fig. 1C; P=0.71). Conclusions Resting measures of cardiac function are insensitive to significant cardiac dysfunction amongst pediatric cancer survivors with reduced VO2peak. Measures of cardiopulmonary fitness and cardiac reserve may aid in early identification of survivors with heightened risk of long-term heart failure. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): National Heart Foundation

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Long-Term Follow-Up Care for Pediatric Cancer Survivors

10.1542/9781610020190-part05-long_term ◽

2016 ◽

pp. 1309-1310

Keyword(s):

Cancer Survivors ◽

Pediatric Cancer ◽

Pediatric Cancer Survivors ◽

Follow Up Care ◽

Long Term Follow Up

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Knowledge of hepatitis C virus screening in long-term pediatric cancer survivors

Cancer ◽

10.1002/cncr.24810 ◽

2010 ◽

Vol 116 (4) ◽

pp. 974-982 ◽

Cited By ~ 5

Author(s):

Meagan Lansdale ◽

Sharon Castellino ◽

Neyssa Marina ◽

Pamela Goodman ◽

Melissa M. Hudson ◽

...

Keyword(s):

Hepatitis C Virus ◽

Hepatitis C ◽

Cancer Survivors ◽

Pediatric Cancer ◽

Pediatric Cancer Survivors ◽

Virus Screening

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Quality of life in pediatric cancer survivors: contributions of parental distress and psychosocial family risk

Current Oncology ◽

10.3747/co.25.3768 ◽

2018 ◽

Vol 25 (1) ◽

pp. 41 ◽

Cited By ~ 6

Author(s):

N.M. Racine ◽

M. Khu ◽

K. Reynolds ◽

G.M.T. Guilcher ◽

F.S.M. Schulte

Keyword(s):

Quality Of Life ◽

Psychological Distress ◽

Cancer Survivors ◽

Pediatric Cancer ◽

Psychosocial Risk ◽

Family Risk ◽

Pediatric Cancer Survivors ◽

Low Levels ◽

The Impact

Background Pediatric survivors of childhood cancer are at increased risk of poor quality of life and social-emotional outcomes following treatment. The relationship between parent psychological distress and child adjustment in pediatric cancer survivors has been well established. However, limited research has examined the factors that may buffer this association. The current study examined the associations between psychosocial family risk factors, parental psychological distress, and health-related quality of life (hrql) in pediatric cancer survivors.Methods Fifty-two pediatric cancer survivors (34 males, 18 females, mean age = 11.92) and their parents were recruited from a long-term cancer survivor clinic. Children and their parents who consented to participate completed the Pediatric Quality of Life Inventory 4.0. Parents completed a demographic information form, the Psychosocial Assessment Tool (pat 2.0) and the Brief Symptom Inventory (bsi). The Intensity of Treatment Rating (itr-3) was evaluated by the research team.Results Multiple regression analyses revealed that parental psychological distress negatively predicted parent reported hrql, while treatment intensity, gender, and psychosocial risk negatively predicted parent and child-reported hrql. Psychosocial risk moderated the association between parent psychological distress and parent-reported child hrql (p = 0.03), whereby parents with high psychological distress but low levels of psychosocial risk reported their children to have higher hrql.Conclusion Low levels of family psychosocial risk buffer the impact of parent psychological distress on child hrql in pediatric cancer survivors. The findings highlight the importance of identifying parents and families with at-risk psychological distress and psychosocial risk in order to provide targeted support interventions to mitigate the impact on hrql.

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