scholarly journals Topical Wound Oxygen Therapy in the Treatment of Chronic Diabetic Foot Ulcers

Medicina ◽  
2021 ◽  
Vol 57 (9) ◽  
pp. 917
Author(s):  
Robert G. Frykberg
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Clinical Studies ◽  
Oxygen Therapy ◽  
Chronic Wounds ◽  
Supplemental Oxygen ◽  
Foot Ulcers ◽  
Critical Threshold ◽  
Diabetic Foot Ulcers

Oxygen is a critical component of many biological processes and is essential for wound healing. Chronic wounds are typically characterized as being hypoxic in that the partial pressure of oxygen (pO2) in the center of the wound is often below a critical threshold necessary to fully support those enzymatic processes necessary for tissue repair. Providing supplemental oxygen can effectively raise pO2 levels to better optimize functioning of these essential enzymes. While hyperbaric oxygen therapy has been well studied in this regard, comparative clinical studies have fallen short of providing clear evidence in support of this modality for healing chronic diabetic foot ulcers (DFU). Topical oxygen therapy (TOT) has been in clinical use for over 50 years with encouraging pre-clinical and clinical studies that have shown improved healing rates when compared to standard care. Nonetheless, TOT has heretofore been discounted as an unproven wound healing modality without theoretical or clinical evidence to support its use. This review shall provide a brief summary of the role of oxygen in wound healing and, specifically, discuss the different types of topical oxygen devices and associated studies that have convincingly shown their efficacy in healing chronic DFUs. The time has come for topical oxygen therapy to be embraced as a proven adjunctive modality in this regard.

scholarly journals THE EFFICACY OF HONEY AS AN ALTERNATIVE TO STANDARD ANTISEPTIC CARE IN THE TREATMENT OF CHRONIC PRESSURE ULCERS AND DIABETIC FOOT ULCERS IN ADULTS

2021 ◽  
pp. 37-47
Author(s):  
GF PEREIRA ◽  
M BALMITH ◽  
M NELL
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Bacterial Infections ◽  
Chronic Wounds ◽  
Pressure Ulcers ◽  
Keyword Search ◽  
Selection Process ◽  
Foot Ulcers ◽  
Published Data ◽  
Diabetic Foot Ulcers

Objective: A chronic wound fails to progress through the phases of wound healing in an orderly and appropriate process, and poses a major challenge to wound care professionals. Pressure ulcers (PUs) and diabetic foot ulcers (DFUs) are classified as chronic wounds. Antiseptics, such as povidone-iodine (PVP-I), are often used to treat bacterial infections in chronic wounds; however, their efficacy and ability to accelerate wound healing has come into question. As a result, current medical research is now focusing on alternative and natural antiseptic agents, such as honey, for the treatment of chronic wounds. The aim of this study was to analyze the wound healing effects of honey in PU and DFU treatment in comparison to standard antiseptic care. Methods: A systematic literature search of PubMed, ScienceDirect, and ClinicalKey was conducted to identify all published data of clinical trials and narrative reviews that investigated or reported the use of honey and standard antiseptics in the treatment of PUs and DFUs in adults. A keyword search was then performed using the following keywords: “PUs”, “DFUs”, “antiseptics”, “PVP-I”, “honey”, “Manuka honey (MH)”, and “wound healing”. Database restrictions were implemented based on the inclusion and exclusion criteria, notably the report’s availability, completion status and language, the sample populations’ age, as well as, the date of publication. A preferred reporting item for systematic review and meta-analysis (preferred reporting items for systematic reviews and meta-analyzes) diagram was constructed illustrating the study selection process. The eligibility of articles was assessed by the screening of titles, abstracts and full texts. A total of 12 articles were included in this study comprising of 775 patients with PUs, DFUs or a combination of PUs and DFUs. Results: Results indicated that honey reduced bacterial infection, reduced pain and edema experienced by patients, reduced the odor of the wound and promoted wound healing in the treatment of chronic ulcers. Honey was also found to be effective in the process of debridement and exudate removal. Conclusion: Honey was found to be highly effective in the treatment of PUs and DFUs and should be considered as an alternative to standard antiseptic care in the treatment of chronic wounds. However, the literature in this study is limited and so further research into honey and its antiseptic-promoting activity in wound healing is recommended.

Evaluation of the role of hyperbaric oxygen therapy in the treatment of diabetic foot ulcers: a prospective comparative study

2016 ◽  
Vol 88 (4) ◽  
pp. 219-224 ◽  
Author(s):  
Chandrakant Munjewar ◽  
Ishaq Nabi ◽  
Santosh Gautam ◽  
Neelam Ahirwar ◽  
Poras Chaudhary ◽  
...  
Keyword(s):  
Comparative Study ◽  
Hyperbaric Oxygen ◽  
Diabetic Foot ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Prospective Comparative Study

Topical oxygen therapy results in complete wound healing in diabetic foot ulcers

2016 ◽  
Vol 24 (6) ◽  
pp. 1066-1072 ◽  
Author(s):  
Janelle Yu ◽  
Suzanne Lu ◽  
Ann-Marie McLaren ◽  
Julie A. Perry ◽  
Karen M. Cross
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Oxygen Therapy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Complete Wound Healing

scholarly journals Topical Oxygen Therapy Results in Complete Wound Healing in Diabetic Foot Ulcers

2016 ◽  
Vol 64 (5) ◽  
pp. 1536
Author(s):  
Janelle Yu ◽  
Suzanne Lu ◽  
Ann-Marie McLaren ◽  
Elisa Greco ◽  
Karen Cross
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Oxygen Therapy ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Complete Wound Healing

scholarly journals A clinical study of platelet rich plasma versus conventional dressing in management of diabetic foot ulcers

2018 ◽  
Vol 5 (10) ◽  
pp. 3210 ◽  
Author(s):  
Nithyaraj Prakasam ◽  
Prabakar M.S. ◽  
Reshma S. ◽  
Loganathan K. ◽  
Senguttuvan K.
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Diabetic Foot ◽  
Tamil Nadu ◽  
Chronic Wounds ◽  
Platelet Rich Plasma ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Group A ◽  
Group B

Background: Diabetic foot ulcers continue to pose significant global issue despite the advances made in the management of diabetes. It causes major foot complications if they are not addressed properly. It needs multidisciplinary approach for its care. While several advancements has taken place in wound care management, platelet rich plasma and stem cell therapy promises to offer a new hope in its management, aiding in cellular and tissue regeneration. The purpose of the present study was to compare Platelet-Rich Plasma versus conventional dressing in the management of diabetic foot ulcers.Methods: This prospective study was focused on 20 diabetic foot ulcers, carried out in a surgical unit of ACS Medical College and Hospital, Chennai, Tamil Nadu, from January 2018 to June 2018. Patients were divided into two groups; Group A received conventional ordinary dressing (N=10, 50%) and Group B received PRP dressing (N = 10, 50%). The mean follow-up period was 8 weeks.Results: The estimated time of wound healing was 8 weeks and healing was found to be more effective for patients in group B compared to patients in group A; the PRP group was found to be more effective in wound healing with fewer complications, less infection, exudates and pain.Conclusions: There have been considerable advances in the use of PRP in therapeutic processes in recent years in tissue regeneration therapy. PRP is a powerful tool for the treatment of chronic wounds and very promising for diabetic foot wounds; PRP enables healing, and reduces amputation rates, infection and exudates.

Tissue-specific role of Nrf2 in the treatment of diabetic foot ulcers during hyperbaric oxygen therapy

2019 ◽  
Vol 138 ◽  
pp. 53-62 ◽  
Author(s):  
Umapathy Dhamodharan ◽  
Amin Karan ◽  
Dornadula Sireesh ◽  
Alladi Vaishnavi ◽  
Arumugam Somasundar ◽  
...  
Keyword(s):  
Hyperbaric Oxygen ◽  
Diabetic Foot ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
Specific Role ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Tissue Specific

Alginate/chitosan-based hydrogel loaded with gene vectors to deliver polydeoxyribonucleotide for effective wound healing

2021 ◽  
Author(s):  
Xiaodong Jing ◽  
Yanzhen Sun ◽  
Yang Liu ◽  
Xiaoli Ma ◽  
Hao Hu
Keyword(s):  
Wound Healing ◽  
Diabetic Foot ◽  
Chronic Wounds ◽  
Foot Ulcers ◽  
Pressure Sores ◽  
Leg Ulcers ◽  
Wound Treatment ◽  
Diabetic Foot Ulcers ◽  
Acute Bleeding ◽  
Gene Vectors

Timely and effective wound treatment is of great significance to acute bleeding caused by accidents and chronic wounds such as diabetic foot ulcers, venous leg ulcers, pressure sores. Hydrogel as...

Recent Advances in the Development of Nitric Oxide-Releasing Biomaterials and Their Application Potentials in Chronic Wound Healing

2021 ◽  
Author(s):  
Min Wu ◽  
Zhihui Lu ◽  
Keke Wu ◽  
Changwoo Nam ◽  
Lin Zhang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Persistent Infection ◽  
Diabetic Foot ◽  
Chronic Wounds ◽  
Pressure Ulcers ◽  
Chronic Wound ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers ◽  
Nitric Oxide Releasing

Chronic wounds, such as pressure ulcers, vascular ulcers and diabetic foot ulcers (DFUs), often stays in a state of pathological inflammation and suffers from persistent infection, excess inflammation, and hypoxia,...

163-THE ROLE OF PSYCHOLOGICAL DISTRESS IN WOUND HEALING: THE CASE OF DIABETIC FOOT ULCERS

2004 ◽  
Vol 56 (6) ◽  
pp. 624
Author(s):  
K *Vedhara ◽  
D *Tallon ◽  
L *Gale ◽  
E Dougan ◽  
A Strode ◽  
...  
Keyword(s):  
Wound Healing ◽  
Psychological Distress ◽  
Diabetic Foot ◽  
Foot Ulcers ◽  
Diabetic Foot Ulcers
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