scholarly journals Maternal–Fetal Outcomes in Women with Endometriosis and Shared Pathogenic Mechanisms

Medicina ◽  
2021 ◽  
Vol 57 (11) ◽  
pp. 1258
Author(s):  
Francesca Frincu ◽  
Andreea Carp-Veliscu ◽  
Aida Petca ◽  
Dumitru-Cristinel Badiu ◽  
Elvira Bratila ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Gestational Hypertension ◽  
Obstetric Complications ◽  
Epigenetic Alterations ◽  
Premature Rupture Of Membranes ◽  
Spontaneous Preterm Birth ◽  
Abruptio Placentae ◽  
Pathogenic Mechanisms ◽  
Adverse Pregnancy

The connection between endometriosis and pregnancy outcomes is trending among the research topics. Until recently, endometriosis and its painful symptomatology were considered to be alleviated by pregnancy. However, these beliefs have shifted, as emerging literature has demonstrated the role of this condition in affecting pregnancy evolution. The underlying pathogenesis of endometriosis is still poorly understood, all the more when pregnancy complications are involved. Debatable opinions on endometriosis associated with obstetric complications exist because of the potential bias resulting from the heterogeneity of preceding evidence. This review aims to evaluate the connection between endometriosis and adverse pregnancy outcomes and their shared pathogenic mechanisms. We searched PubMed and EMBASE and focused on the studies that include placenta praevia, premature rupture of membranes, spontaneous preterm birth, gestational hypertension, preeclampsia, obstetric hemorrhages (ante- and postpartum bleeding, abruptio placentae), miscarriage, stillbirth, neonatal death, gestational diabetes mellitus, gestational cholestasis, small for gestational age, and their association with endometriosis. Not only the risks of emergence were highlighted, but also the pathogenic connections. Epigenetic alterations of some genes were found to be mirrored both in endometriosis and obstetric complications. This review issues a warning for providing increased attention to pregnant women with endometriosis and newborns as higher risks of preeclampsia, placental issues, and preterm deliveries are associated.

Placental massive perivillous fibrinoid deposition is associated with adverse pregnancy outcomes: a clinicopathological study of 12 cases

2016 ◽  
Vol 5 (1) ◽  
pp. 35-39
Author(s):  
Maili Qi ◽  
Kenneth Tou En Chang ◽  
Derrick Wen Quan Lian ◽  
Chong Kiat Khoo ◽  
Kok Hian Tan
Keyword(s):  
Pregnancy Outcomes ◽  
Gestational Hypertension ◽  
Local Population ◽  
Fetal Loss ◽  
Perinatal Outcomes ◽  
First Trimester ◽  
Adverse Outcomes ◽  
Special Focus ◽  
Adverse Perinatal Outcomes ◽  
Adverse Pregnancy

Abstract Introduction: Massive perivillous fibrinoid deposition (MPFD) is a very rare placental condition characterized by abnormally extensive fibrinoid deposition in the placental villous parenchyma. The aim of this study is to document clinical and pathological features with special focus on pregnancy outcomes of this condition in consecutive cases of MPFD in our local population. Methods: This is a retrospective clinico-pathological study of cases affected by MPFD over the period January 2010–July 2014 in our hospital. We document clinical features (including perinatal outcome and subsequent pregnancies) and placental pathological characteristics. Results: Twelve cases of MPFD were identified among 3640 placentas (0.33%). There was no identified recurrence. The affected infants had adverse outcomes, including intrauterine growth restriction (IUGR) (75%), preterm birth (58.3%), and fetal loss (25%). A high frequency of reduced PAPP-A in the first trimester (25%), and concurrent gestational hypertension or pre-eclampsia (25%) was noted. Conclusion: MPFD is associated with adverse perinatal outcomes. Further research to better understand its pathogenesis and to improve clinical diagnosis and management is warranted.

scholarly journals Impact of Wildfire Smoke on Adverse Pregnancy Outcomes in Colorado, 2007–2015

2019 ◽  
Vol 16 (19) ◽  
pp. 3720 ◽  
Author(s):  
Mona Abdo ◽  
Isabella Ward ◽  
Katelyn O’Dell ◽  
Bonne Ford ◽  
Jeffrey Pierce ◽  
...  
Keyword(s):  
Birth Weight ◽  
Pregnancy Outcomes ◽  
Gestational Hypertension ◽  
Adverse Pregnancy Outcomes ◽  
Adverse Outcomes ◽  
Wildfire Smoke ◽  
Secondary Outcomes ◽  
Adverse Pregnancy ◽  
The Impact ◽  
Zip Code

Colorado is regularly impacted by long-range transport of wildfire smoke from upwind regions. This smoke is a major source of ambient PM2.5. Maternal exposure to total PM2.5 during pregnancy has been linked to decreased birth weight and other adverse outcomes, although the impact of wildfire smoke contribution has only recently been investigated. The objective of this study was to estimate associations between adverse pregnancy outcomes and ambient wildfire smoke PM2.5. Wildfire smoke PM2.5 exposures were estimated using a previously published method incorporating ground-based monitors and remote sensing data. Logistic regression models stratified by ZIP code and mixed models with random intercept by ZIP code were used to test for associations. The primary outcomes of interest were preterm birth and birth weight. Secondary outcomes included gestational hypertension, gestational diabetes, neonatal intensive care unit admission, assisted ventilation, small for gestational age, and low birth weight. Exposure to wildfire smoke PM2.5 over the full gestation and during the second trimester were positively associated with pre-term birth (OR = 1.076 (μg/m3)−1 [95% CI = 1.016, 1.139; p = 0.013] and 1.132 (μg/m3)−1 [95% CI = 1.088, 1.178]; p < 0.0001, respectively), while exposure during the first trimester was associated with decreased birth weight (−5.7 g/(μg/m3) [95% CI: −11.1, −0.4; p = 0.036]). Secondary outcomes were mixed.

Pathogenic Mechanisms Linking Periodontal Diseases With Adverse Pregnancy Outcomes

2012 ◽  
Vol 19 (6) ◽  
pp. 633-641 ◽  
Author(s):  
I. Cetin ◽  
P. Pileri ◽  
A. Villa ◽  
S. Calabrese ◽  
L. Ottolenghi ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Periodontal Diseases ◽  
Adverse Pregnancy Outcomes ◽  
Pathogenic Mechanisms ◽  
Adverse Pregnancy

scholarly journals Association of FOXD1 variants with adverse pregnancy outcomes in mice and humans

Open Biology ◽  
2016 ◽  
Vol 6 (10) ◽  
pp. 160109 ◽  
Author(s):  
Paul Laissue ◽  
Besma Lakhal ◽  
Magalie Vatin ◽  
Frank Batista ◽  
Gaëtan Burgio ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Quantitative Traits ◽  
High Rate ◽  
Sequencing Analysis ◽  
Mus Spretus ◽  
Recombinant Congenic Strain ◽  
Dna Fragment ◽  
Adverse Pregnancy

Recurrent spontaneous abortion (RSA) is a common cause of infertility, but previous attempts at identifying RSA causative genes have been relatively unsuccessful. Such failure to describe RSA aetiological genes might be explained by the fact that reproductive phenotypes should be considered as quantitative traits resulting from the intricate interaction of numerous genetic, epigenetic and environmental factors. Here, we studied an interspecific recombinant congenic strain (IRCS) of Mus musculus from the C57BL6/J strain of mice harbouring an approximate 5 Mb DNA fragment from chromosome 13 from Mus spretus mice (66H-MMU13 strain), with a high rate of embryonic resorption (ER). Transcriptome analyses of endometrial and placental tissues from these mice showed a deregulation of many genes associated with the coagulation and inflammatory response pathways. Bioinformatics approaches led us to select Foxd1 as a candidate gene potentially related to ER and RSA. Sequencing analysis of Foxd1 in the 66H-MMU13 strain, and in 556 women affected by RSA and 271 controls revealed non-synonymous sequence variants. In vitro assays revealed that some led to perturbations in FOXD1 transactivation properties on promoters of genes having key roles during implantation/placentation, suggesting a role of this gene in mammalian implantation processes.

scholarly journals Obstetric complications and adverse pregnancy outcomes among elderly primigravidae of age 35 years and above in Oman

2019 ◽  
Vol 5 (3) ◽  
Author(s):  
Amira Al Ghailani ◽  
Vaidyanathan Gowri ◽  
Fatma Ali Said Al Hoqani ◽  
Aisha Khamis Mohammed Al Belushi ◽  
M Mazharul Islam
Keyword(s):  
Pregnancy Outcomes ◽  
Adverse Pregnancy Outcomes ◽  
Obstetric Complications ◽  
Adverse Pregnancy

scholarly journals The Proportion of Excised Cone Volume for Cervical Lesions is the Best Predictor of Pregnancy Outcomes after Cervical Conization

2021 ◽  
Author(s):  
Yahui Wang ◽  
Wei Lin ◽  
Youjun Luo ◽  
Zhaoyuan Niu ◽  
Yanhui Du ◽  
...  
Keyword(s):  
Pregnancy Outcomes ◽  
Area Under The Curve ◽  
Inverse Correlation ◽  
Cervical Length ◽  
Reproductive Period ◽  
Cervical Lesions ◽  
Spontaneous Preterm Birth ◽  
Predictive Values ◽  
Adverse Pregnancy ◽  
Cervical Conization

Abstract Background: As much more women in the reproductive period are treated with a cervical conization, the risk of subsequent adverse pregnancy outcomes is also increasing. We carried the present study to evaluate whether absolute cone length/volume and the proportions of the cone length/volume correlate to spontaneous abortion (SAB) and spontaneous preterm birth (SPTB) and their predictive values.Methods: The present retrospective observational study included 312 women undergoing cervical conization for cervical lesions at the Affiliated Hospital of Qingdao University during 2012–2019. The information about the pretreatment cervical dimensions and cone size and pregnancy outcomes were collected to assess the correlation between cone parameters and pregnancy outcomes.Results: In the multivariate logistic regression models, the cervical length excised, the cervical volume excised, the proportion of the length excised, and the proportion of the cervical volume excised significantly correlated with SAB and SPTB, respectively (P<0.05). A most significant inverse correlation of the proportion of the cervical volume excised with pregnancy duration emerged (P<0.001, r=-0.220). The area under the curve (AUC) of the proportion of the cervical volume excised was greatest (0.700,95% CI 0.634-0.765). And the risk of SAB and SPTB increased with the proportion of the cervical volume excised increasing (OR 19.704, 95% CI 4.646-83.568). The cutoff point of the proportion of the cervical volume excised was 19.5% (sensitivity 0.635; specificity 0.655). Conclusion: The cone length/volume and the proportions of cervical length/volume excised were associated with increased risks of SAB and SPTB. The proportion of the cervical volume excised is the best predictor for SAB and SPTB after cervical conization. When the proportion of the cervical volume excised is more than 19.5%, women should be informed about their future risk of SAB and SPTB after cervical conization for cervical lesions.

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