scholarly journals MOBP rs616147 Polymorphism and Risk of Amyotrophic Lateral Sclerosis in a Greek Population: A Case-Control Study

Medicina ◽  
2021 ◽  
Vol 57 (12) ◽  
pp. 1337
Author(s):  
Ioannis Liampas ◽  
Vasileios Siokas ◽  
Athina-Maria Aloizou ◽  
Christos Bakirtzis ◽  
Zisis Tsouris ◽  
...  

Background and Objectives: To date, only one study has investigated the association between the rs616147 polymorphism of the Myelin-associated Oligodendrocyte Basic Protein (MOBP) locus and Amyotrophic Lateral Sclerosis (ALS). Materials and Methods: A case-control study was performed. Patients with definite sporadic ALS were prospectively and consecutively recruited from the inpatient and outpatient clinics of the Neurology Department of the General University Hospital of Larissa, Central Greece. Community based, age and sex matched healthy individuals with a free personal and family history constituted the control group. Results: A total of 155 patients with definite sporadic ALS and an equal number of healthy controls were genotyped. The power of our sample size was slightly above 80% and MOBP rs616147 was determined to be in Hardy-Weinberg Equilibrium among healthy participants (p = 1.00). According to the univariate analysis, there was no significant relationship between rs616147 and ALS [log-additive OR = 0.85 (0.61, 1.19), over-dominant OR = 0.73 (0.46, 1.15), recessive OR = 1.02 (0.50, 2.09), dominant OR = 0.74 (0.47, 1.16), co-dominant OR1 = 0.71 (0.44, 1.14) and co-dominant OR2 = 0.88 (0.42, 1.84). Additionally, the effect of rs616147 on the age of ALS onset was determined insignificant using both unadjusted and adjusted (sex, site of onset) cox-proportional models. Finally, rs616147 was not related to the site of ALS onset. Conclusions: Our study is the first to report the absence of an association between MOBP rs616147 and ALS among individuals of Greek ancestry. Additional, larger nationwide and multi-ethnic studies are warranted to shed light on the connection between rs616147 and ALS.

2011 ◽  
Vol 14 (4) ◽  
pp. 580-588 ◽  
Author(s):  
Izabel Marcilio ◽  
Nelson Gouveia ◽  
Mário Leite Pereira Filho ◽  
Leeka Kheifets

Recent publications renewed interest in assessing potential health risks for subjects living close to transmission lines. This study aimed at evaluating the association of both distance of home address to the nearest overhead transmission line and of the calculated magnetic fields from the power lines and mortality from leukemia, brain cancer, and amyotrophic lateral sclerosis. We carried out a death certificate based case-control study accessing adult mortality in the Metropolitan Region of São Paulo, in Brazil. Analysis included 1,857 cases of leukemia, 2,357 of brain cancer, 367 of amyotrophic lateral sclerosis, and 4,706 as controls. An increased risk for mortality from leukemia among adults living at closer distances to transmission lines compared to those living further then 400 m was found. Risk was higher for subjects that lived within 50 m from power lines (OR=1.47; 95% CI=0.99-2.18). Similarly, a small increase in leukemia mortality was observed among adults living in houses with higher calculated magnetic fields (OR=1.61; 95% CI=0.91-2.86 for those exposed to magnetic fields >0.3 µT). No increase was seen for brain tumours or amyotrophic lateral sclerosis. Our findings are suggestive of a higher risk for leukemia among subjects living closer to transmission lines, and for those living at homes with higher calculated magnetic fields, although the risk was limited to lower voltage lines.


2012 ◽  
Vol 19 (12) ◽  
pp. 1509-1517 ◽  
Author(s):  
E. Pupillo ◽  
P. Messina ◽  
G. Logroscino ◽  
S. Zoccolella ◽  
A. Chiò ◽  
...  

1986 ◽  
Vol 5 (1) ◽  
pp. 29-38 ◽  
Author(s):  
Louise S. Gresham ◽  
Craig A. Molgaard ◽  
Amanda L. Golbeck ◽  
Richard Smith

2015 ◽  
Vol 359 (1-2) ◽  
pp. 11-17 ◽  
Author(s):  
Beatrice Bocca ◽  
Giovanni Forte ◽  
Riccardo Oggiano ◽  
Simonetta Clemente ◽  
Yolande Asara ◽  
...  

2002 ◽  
Vol 89 (2) ◽  
pp. 116-123 ◽  
Author(s):  
Margherita Bergomi ◽  
Marco Vinceti ◽  
Grazia Nacci ◽  
Vladimiro Pietrini ◽  
Peter Brätter ◽  
...  

2013 ◽  
Vol 14 (1) ◽  
pp. 31-38 ◽  
Author(s):  
Angela M. Malek ◽  
Aaron Barchowsky ◽  
Robert Bowser ◽  
Terry Heiman-Patterson ◽  
David Lacomis ◽  
...  

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