scholarly journals Emerging Utility of Applied Magnetic Resonance Imaging in the Management of Traumatic Brain Injury

2021 ◽  
Vol 9 (1) ◽  
pp. 10
Author(s):  
Jeffrey Nadel ◽  
Joseph Scott McNally ◽  
Anthony DiGiorgio ◽  
Ramesh Grandhi

Traumatic brain injury (TBI) is a widespread and expensive problem globally. The standard diagnostic workup for new TBI includes obtaining a noncontrast computed tomography image of the head, which provides quick information on operative pathologies. However, given the limited sensitivity of computed tomography for identifying subtle but meaningful changes in the brain, magnetic resonance imaging (MRI) has shown better utility for ongoing management and prognostication after TBI. In recent years, advanced applications of MRI have been further studied and are being implemented as clinical tools to help guide care. These include functional MRI, diffusion tensor imaging, MR perfusion, and MR spectroscopy. In this review, we discuss the scientific basis of each of the above techniques, the literature supporting their use in TBI, and how they may be clinically implemented to improve the care of TBI patients.






2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Xuan Vinh To ◽  
Fatima A. Nasrallah

AbstractConcussion or mild traumatic brain injury is the most common form of traumatic brain injury with potentially long-term consequences. Current objective diagnosis and treatment options are limited to clinical assessment, cognitive rest, and symptom management, which raises the real danger of concussed patients being released back into activities where subsequent and cumulative injuries may cause disproportionate damages. This study conducted a cross-sectional multi-modal examination investigation of the temporal changes in behavioural and brain changes in a mouse model of concussion using magnetic resonance imaging. Sham and concussed mice were assessed at day 2, day 7, and day 14 post-sham or injury procedures following a single concussion event for motor deficits, psychological symptoms with open field assessment, T2-weighted structural imaging, diffusion tensor imaging (DTI), neurite orientation density dispersion imaging (NODDI), stimulus-evoked and resting-state functional magnetic resonance imaging (fMRI). Overall, a mismatch in the temporal onsets and durations of the behavioural symptoms and structural/functional changes in the brain was seen. Deficits in behaviour persisted until day 7 post-concussion but recovered at day 14 post-concussion. DTI and NODDI changes were most extensive at day 7 and persisted in some regions at day 14 post-concussion. A persistent increase in connectivity was seen at day 2 and day 14 on rsfMRI. Stimulus-invoked fMRI detected increased cortical activation at day 7 and 14 post-concussion. Our results demonstrate the capabilities of advanced MRI in detecting the effects of a single concussive impact in the brain, and highlight a mismatch in the onset and temporal evolution of behaviour, structure, and function after a concussion. These results have significant translational impact in developing methods for the detection of human concussion and the time course of brain recovery.



2012 ◽  
Vol 6 (2) ◽  
pp. 137-192 ◽  
Author(s):  
M. E. Shenton ◽  
H. M. Hamoda ◽  
J. S. Schneiderman ◽  
S. Bouix ◽  
O. Pasternak ◽  
...  




2020 ◽  
Vol 5 (4) ◽  
pp. 239-244
Author(s):  
A. V. Yarikov ◽  
I. A. Lobanov ◽  
V. A. Leonov ◽  
A. P. Fraerman ◽  
S. V. Nikolenko

Traumatic brain injury is one of the most frequent types of injuries and ranks first among the causes of mortality and disability of the working population. The timely diagnosis of brain damage is one of the ways of improving the quality of emergency neurosurgical treatment of severe traumatic brain injury. Choosing the right diagnostic method allows you to assess the volume, severity of the injury and apply the correct treatment tactics. This paper describes in detail the special methods of magnetic resonance imaging used in the diagnosis of traumatic brain injury (MR cisternography, perfusion MRI, MR spectroscopy, diffusion-weighted and diffusion tensor MRI). The diagnostic capabilities, advantages and disadvantages of each method are discussed.



2015 ◽  
Vol 5 (2) ◽  
pp. 79-84 ◽  
Author(s):  
S. D. W. Buttram ◽  
P. Garcia-Filion ◽  
J. Miller ◽  
M. Youssfi ◽  
S. Danielle Brown ◽  
...  


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