scholarly journals A Palladium Catalyst System for the Efficient Cross-Coupling Reaction of Aryl Bromides and Chlorides with Phenylboronic Acid: Synthesis and Biological Activity Evaluation

Molecules ◽  
2017 ◽  
Vol 22 (3) ◽  
pp. 420 ◽  
Author(s):  
Boubakri Lamia ◽  
Ahlem Chakchouk-Mtibaa ◽  
Bilel Hallouma ◽  
Lamjed Mansour ◽  
Lotfi Mellouli ◽  
...  
Keyword(s):  
Biological Activity ◽  
Palladium Catalyst ◽  
Phenylboronic Acid ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Acid Synthesis ◽  
Catalyst System ◽  
Activity Evaluation ◽  
Aryl Bromides ◽  
Cross Coupling Reaction

Synthesis, Characterization and Catalytic Utilization of a Ferrocene Diamidodiphosphane

2007 ◽  
Vol 72 (4) ◽  
pp. 453-467 ◽  
Author(s):  
Petr Štěpnička ◽  
Jiří Schulz ◽  
Ivana Císařová ◽  
Karla Fejfarová
Keyword(s):  
Phenylboronic Acid ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Aryl Halides ◽  
Coupling Reactions ◽  
Aryl Chlorides ◽  
Highly Active ◽  
Aryl Bromides ◽  
Cross Coupling Reaction

Amidation of 1'-(diphenylphosphanyl)ferrocene-1-carboxylic acid (Hdpf) with ethane-1,2-diamine afforded N,N'-ethylenebis[1'-(diphenylphosphanyl)ferrocene-1-carboxamide] (1), which was isolated in free and solvated form, 1·2AcOH. Both 1 and Hdpf were further converted to their respective phosphane sulfides, 2·2AcOH and 3 that were structurally characterized. Testing of the amidophosphane ligands in Suzuki-Miyaura cross-coupling reaction between phenylboronic acid and various aryl halides revealed that catalyst formed in situ from 1 and palladium(II) acetate is highly active in coupling reactions of aryl bromides whilst the corresponding aryl chlorides showed no or only poor conversions. The catalyst based on 2·2AcOH gave markedly lower yields of the coupling products.

Umpolung Coupling of Pyridine-2-carboxaldehydes and Propargylic Carbonates via N-Heterocyclic Carbene/Palladium Synergetic Catalysis

2021 ◽  
Author(s):  
Weiyang Bi ◽  
Yunhui Yang ◽  
Song Ye ◽  
Congyang Wang
Keyword(s):  
Palladium Catalyst ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Cooperative Catalysis ◽  
Cross Coupling Reaction ◽  
First Time

The umpolung cross-coupling reaction of pyridine-2-carboxaldehydes and propargylic carbonates has been developed for the first time through N-heterocyclic carbene/palladium cooperative catalysis with the judicious selections of the palladium catalyst, ligand...

scholarly journals Factorial design evaluation of the Suzuki cross-coupling reaction using a magnetically recoverable palladium catalyst

2017 ◽  
Vol 58 (10) ◽  
pp. 903-908 ◽  
Author(s):  
Raíza R.G. Guerra ◽  
Felipe C.P. Martins ◽  
Carolina G.S. Lima ◽  
Ricardo H. Gonçalves ◽  
Edson R. Leite ◽  
...  
Keyword(s):  
Factorial Design ◽  
Palladium Catalyst ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Design Evaluation ◽  
Cross Coupling Reaction

scholarly journals Flow Process Development and Optimization of A Suzuki-Miyaura Cross Coupling Reaction using Response Surface Methodology

2020 ◽  
Vol 15 (3) ◽  
pp. 604-616
Author(s):  
Girish Basavaraju ◽  
Ravishankar Rajanna
Keyword(s):  
Response Surface Methodology ◽  
Response Surface ◽  
Flow Reactor ◽  
Phenylboronic Acid ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Flow Process ◽  
Cross Coupling Reaction ◽  
Custom Made ◽  
Good Agreement

A custom-made tubular flow reactor was utilized to develop a mathematical model and optimize the Suzuki-Miyaura cross coupling reaction. In this study, the experimentation was designed and executed through the statistical design of experiments (DoE) approach via response surface methodology. The effect of molar ratios of phenylboronic acid (1) and 4-bromophenol (2), temperature, the catalyst tetrakis(triphenylphosphine)palladium, and equivalence of aqueous tripotassium phosphate was studied in detail. The flow reactor profile was in good agreement with batch conditions and significant improvements to the overall reaction time and selectivity towards desired [1-1-biphenyl]-4-ol (3) was achieved. The Suzuki coupling reaction in batch condition would take on an average of 4 to 6 hours to complete, which was effectively accomplished in 60 to 70 minutes in this tubular reactor setup and could be operated continuously. The reaction model is in good agreement with the reaction conditions. Copyright © 2020 BCREC Group. All rights reserved 

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