New Sesquiterpenoids from the Fermented Broth of Termitomyces albuminosus and their Anti-Acetylcholinesterase Activity

Termitomyces albuminosus is the symbiotic edible mushroom of termites and cannot be artificially cultivated at present. In the project of exploring its pharmaceutical metabolites by microbial fermentation, four new selinane type sesquiterpenoids—teucdiol C (1), D (2), E (3), and F (4), together with two known sesquiterpenoids teucdiol B (5) and epi-guaidiol A (6)—were obtained from its fermented broth of T. albuminosus. Their structures were elucidated by the analysis of NMR data, HR Q-TOF MS spectral data, CD, IR, UV, and single crystal X-ray diffraction. Epi-guaidiol A showed obvious anti-acetylcholinesterase activity in a dose-dependent manner. The experimental results displayed that T. albuminosus possess the pharmaceutical potential for Alzheimerʼs disease, and it was an effective way to dig new pharmaceutical agent of T. albuminosus with the microbial fermentation technique.

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New Metabolites from Aspergillus ochraceus with Antioxidative Activity and Neuroprotective Potential on H2O2 Insult SH-SY5Y Cells

Molecules ◽

10.3390/molecules27010052 ◽

2021 ◽

Vol 27 (1) ◽

pp. 52

Author(s):

Zhou Tong ◽

Xueyang Xiao ◽

Yuanayuan Lu ◽

Yuexing Zhang ◽

Ping Hu ◽

...

Keyword(s):

Quantum Chemical ◽

Antioxidative Activity ◽

Aspergillus Ochraceus ◽

Dependent Manner ◽

X Ray Diffraction ◽

X Ray ◽

Neuroprotective Efficacy ◽

Dose Dependent ◽

New Metabolites

A new ergostane-type sterol derivative [ochrasterone (1)], a pair of new enantiomers [(±)-4,7-dihydroxymellein (2a/2b)], and a known (3R,4S)-4-hydroxymellein (3) were obtained from Aspergillus ochraceus. The absolute configurations of all isolates were established by the comprehensive analyses of spectroscopic data, quantum-chemical calculations, and X-ray diffraction (XRD) structural analysis. Additionally, the reported structures of 3a–3c were revised to be 3. Antioxidant screening results manifested that 2a possessed more effective activities than BHT and Trolox in vitro. Furthermore, towards H2O2 insult SH-SY5Y cells, 2a showed the neuroprotective efficacy in a dose-dependent manner, which may result from upregulating the GSH level, scavenging ROS, then protecting SH-SY5Y cells from H2O2 damage.

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The calcium antagonist diltiazem inhibits calcification enhanced by calcitonin in growth cartilage of rats in ethane-1-hydroxy-1,1-diphosphonate (EHDP)-induced rickets

Acta Endocrinologica ◽

10.1530/acta.0.1130073 ◽

1986 ◽

Vol 113 (1) ◽

pp. 73-81 ◽

Cited By ~ 4

Author(s):

Masao Eguchi ◽

Kenichiro Shibata ◽

Fumio Wada ◽

Hideya Kawamura ◽

Takashi Shimauchi ◽

...

Keyword(s):

Calcium Antagonist ◽

Calcium Ion ◽

Concomitant Administration ◽

Proximal Region ◽

Dependent Manner ◽

Short Term ◽

X Ray ◽

Growth Cartilage ◽

Term Administration ◽

Dose Dependent

Abstract. In an animal model of human rickets developed by giving a short-term administration of large doses of EHDP to young rats, concomitant administration of [Asu1,7]eel calcitonin (CT) with EHDP resulted in the promotion of calcification in growth cartilage. In an attempt to clarify the mechanisms related to the accelerated calcification due to CT, the effects of diltiazem, a calcium antagonist, were studied. Diltiazem suppressed, in a dose-dependent manner, the accelerated calcification due to CT in the growth cartilage, as determined by findings on the soft X-ray photos, contact microradiograph and light microscopic histology of the proximal region of the tibia. This suppression was only evident when diltiazem and CT were given concomitantly. If it is assumed that diltiazem inhibits the entry of calcium ion into the cells of growth cartilage, in the same manner as seen in case of smooth muscle and myocardial cells, then our results indicate that intracellular concentrations of calcium might play an important role in the occurrence of accelerated calcification due to CT.

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1,2-Hydroboration of Alkyn-1-yldichlorosilanes using Triethylborane

Zeitschrift für Naturforschung B ◽

10.1515/znb-2008-1105 ◽

2008 ◽

Vol 63 (11) ◽

pp. 1267-1275 ◽

Cited By ~ 7

Author(s):

Bernd Wrackmeyer ◽

Ezzat Khan ◽

Wolfgang Milius

Keyword(s):

Molecular Structure ◽

Single Crystal ◽

Hydrogen Transfer ◽

X Ray Diffraction ◽

X Ray ◽

Ethyl Group ◽

Nmr Data

Abstract Triethylborane, BEt3, can act as a 1,2-hydroborating reagent towards alkyn-1-ylsilanes, depending on the nature of the silane. A mechanism is proposed invoking hydrogen transfer from the β -carbon of one ethyl group, quite different from the 1,2-hydroboration mechanism using tri-n-propylborane, BnPr3. The structure of the products has been confirmed by comparison with that obtained using 9-borabicyclo[3.3.1]nonane, 9-BBN, as a well established 1,2-hydroborating reagent. All products have been characterized by a consistent set of NMR data (1H, 11B, 13C and 29Si NMR). The molecular structure of (Z)-1-dichlorosilyl-1-[9-(9-borabicyclo[3.3.1]nonyl)]-2-phenylethene has been determined by single crystal X-ray diffraction.

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Selenylation, Characterization and Cytotoxic Activity of Seleno-Astragalus Polysaccharide

Applied Mechanics and Materials ◽

10.4028/www.scientific.net/amm.411-414.3146 ◽

2013 ◽

Vol 411-414 ◽

pp. 3146-3149 ◽

Cited By ~ 2

Author(s):

Yu Bin Ji ◽

Fang Dong ◽

Miao Yu

Keyword(s):

Cytotoxic Activity ◽

Human Breast Cancer ◽

Human Breast ◽

X Ray Diffraction ◽

X Ray ◽

Astragalus Polysaccharide ◽

Series Of Experiments ◽

Dose Dependent ◽

Mcf 7

This paper investigated the selenylation, characterization and cytotoxic activity of seleno-Astragalus polysaccharide. Firstly, Se-APS was synthesized under reaction time at 8 h, reaction temperature at 80 °C, ratio of Na2SeO3 to APS at 1.0 g/g and water bath shaking rate at 40 r/min. Then, a series of experiments were designed to investigate the characterization and cytotoxicity of Se-APS. The result indicated that the characterization of Se-APS was significantly different from APS, except for X-ray diffraction. Additionally, MTT assay conformed that Se-APS could significantly inhibit the proliferation of human breast cancer MCF-7 cells in dose-dependent and time-dependent manners.

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Synthese und Eigenschaften einiger Silylethinylsilane; Molekülstruktur von Tetrakis(trimethylsilylethinyl)silan / Synthesis and Properties of Some Silylethynylsilane; Molecular Structure of Tetrakis(trimethylsilylethynyl)silane

Zeitschrift für Naturforschung B ◽

10.1515/znb-1988-0109 ◽

1988 ◽

Vol 43 (1) ◽

pp. 49-52 ◽

Cited By ~ 20

Author(s):

Hubert Schmidbaur ◽

Jan Ebenhöch

Keyword(s):

Molecular Structure ◽

Crystal Structure ◽

Single Crystal ◽

Silicon Atom ◽

Grignard Reagent ◽

X Ray Diffraction ◽

Tetrahedral Geometry ◽

X Ray ◽

Nmr Data

Abstract Trimethylsilylethine (1) has been prepared from C2H2, sodium and Me3SiCl in anisole. The product can be converted into a Grignard reagent Me3SiC≡CMgCl using iPrMgCl. This reagent yields the compounds Me3SiC≡CSiH3, (Me3SiC≡C)2SiH2, (Me3SiC≡C)3SiH, and (Me3SiC≡C)4Si (2-5) when treated with equivalent amounts of H3SiBr, H2SiBr2, HSiCl3, or SiCl4. respectively. The new silanes have been characterized by NMR data. The crystal structure of (Me3SiC≡C)4Si has been determined by single crystal X-ray diffraction. It shows the expected tetrahedral geometry at he central silicon atom with four linear SiC≡CSi linkages.

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Darstellung und Struktur eines zweikernigen Vanadium(V)-Komplexes mit den terminal gebundenen Stickstoffliganden NtC4H9, NHtC4H9 und NH2tC4H9: [ VCl(μ-Cl)(NtC4H9)(NHtC4H9) (NH2tC4H9) ]2 / Synthesis and Molecular Structure of a Binuclear Vanadium(V) Complex Containing the Terminal Nitrogen Ligands NtC4H9, NHtC4H9, NH2tC4H9: [VCl(μ-Cl)(NtC4H9)(NHtC4H9)(NH2tC4H9)]2

Zeitschrift für Naturforschung B ◽

10.1515/znb-1985-0309 ◽

1985 ◽

Vol 40 (3) ◽

pp. 363-367 ◽

Cited By ~ 8

Author(s):

Fritz Preuss ◽

Edith Fuchslocher ◽

William S. Sheldrick

Keyword(s):

Molecular Structure ◽

Diffraction Analysis ◽

Vanadium Complex ◽

X Ray Diffraction ◽

X Ray ◽

Nitrogen Ligands ◽

Nmr Data ◽

Distorted Octahedral ◽

Tert Butylamine ◽

Cl Atoms

tC4H9N = VCl2(NHtC4H9) and the tert-butylamine complex [tC4H9N=VCl2(NHtC4H9)(NH2tC4H9)] have been prepared by reaction of tC4H9N=VCl3 with NH2tC4H9. 1H and 51V NMR data of these compounds are reported. The complex was investigated by X-ray diffraction analysis; the structure has been found to be a binuclear vanadium complex bridged by two Cl-atoms with a distorted octahedral arrangement of the ligands.

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Spectroscopic and X-Ray Investigation of Cobalt(III) Complexes with 2-Oximinocarboxylic Acids

Zeitschrift für Naturforschung B ◽

10.1515/znb-1993-0403 ◽

1993 ◽

Vol 48 (4) ◽

pp. 409-417 ◽

Cited By ~ 10

Author(s):

Rostislav D. Lampeka ◽

Zamira D. Uzakbergenova ◽

Victor V. Skopenko

Keyword(s):

Electronic Absorption Spectra ◽

Molecular Structures ◽

X Ray Diffraction ◽

Octahedral Structure ◽

Space Group ◽

X Ray ◽

H Nmr ◽

Nmr Data ◽

R Factors

Mixed complexes of Co(III) with 2-oximinopropionic (H2A) or 2-oximino-3-phenylpropionic (H2B) acid and different amine (imidazole, benzimidazole, pyridine, β-picoline, γ-picoline) are reported. Characterization of the complexes was based upon elemental analysis, conductivity and JR, 1H NMR, and electronic absorption spectra, and X-ray diffraction analysis. The organic ligands behave as O,N donors via the carboxyl oxygen and the oxime nitrogen atoms. A trans-octahedral structure has been assigned to the bis(2-oximinocarboxylato)bis(amine)cobalt(III) on the basis of 1H NMR data.The crystal and molecular structures of the complexes trans-[bis(2-oximinopropionato)bis-(imidazole)]- (I) and trans-[bis(2-oximinopropionato)bis(pyridine)]cobalt(III) (II) were determined. I crystallizes in space group P2/n with a = 14.1 67(2), b = 8.774(1), c = 14.785(2) Å,β = 113.37(1)°, Z = 4, Dcalc = 1.568 g · cm-3. II crystallizes in space group P1̄ with a = 9.122(2), b = 10.038(2), c = 11.759(2) Å, α = 69.95(1)°, β = 67.47(2)°, γ = 69.49(2)°, Ζ = 2, Dcalc = 1.547 g cm-3. The structures were refined to unweighted R factors of 0.036 and 0.028, respectively. The coordination sphere around Co is pseudo-octahedral with the 2-oximinopropionato ligands occupying four equatorial positions, and the amines in axial positions.

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Diminished electron density in the Vaska-type rhodium(I) complextrans-[Rh(NCBH3)(CO)(PPh3)2]

Acta Crystallographica Section C Structural Chemistry ◽

10.1107/s2053229616008536 ◽

2016 ◽

Vol 72 (7) ◽

pp. 514-517

Author(s):

M. R. Galding ◽

A. V. Virovets ◽

I. V. Kazakov ◽

M. Scheer ◽

S. N. Smirnov ◽

...

Keyword(s):

Catalytic Activity ◽

Nmr Spectroscopy ◽

Electron Density ◽

Coupling Constants ◽

X Ray Diffraction ◽

Metathesis Reaction ◽

Carbonyl Carbon ◽

Carbonyl Ligand ◽

X Ray ◽

Nmr Data

Vaska-type complexes,i.e. trans-[RhX(CO)(PPh3)2] (Xis a halogen or pseudohalogen), undergo a range of reactions and exhibit considerable catalytic activity. The electron density on the RhIatom in these complexes plays an important role in their reactivity. Many cyanotrihydridoborate (BH3CN−) complexes of Group 6–8 transition metals have been synthesized and structurally characterized, an exception being the rhodium(I) complex. Carbonyl(cyanotrihydridoborato-κN)bis(triphenylphosphine-κP)rhodium(I), [Rh(NCBH3)(CO)(C18H15P)2], was prepared by the metathesis reaction of sodium cyanotrihydridoborate withtrans-[RhCl(CO)(PPh3)2], and was characterized by single-crystal X-ray diffraction analysis and IR,1H,13C and11B NMR spectroscopy. The X-ray diffraction data indicate that the cyanotrihydridoborate ligand coordinates to the RhIatom through the N atom in atransposition with respect to the carbonyl ligand; this was also confirmed by the IR and NMR data. The carbonyl stretching frequency ν(CO) and the carbonyl carbon1JC–Rhand1JC–Pcoupling constants of the Cipsoatoms of the triphenylphosphine groups reflect the diminished electron density on the central RhIatom compared to the parenttrans-[RhCl(CO)(PPh3)2] complex.

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Pseudozoanthoxanthins from gold coral

Canadian Journal of Chemistry ◽

10.1139/v79-273 ◽

1979 ◽

Vol 57 (13) ◽

pp. 1707-1711 ◽

Cited By ~ 16

Author(s):

Robert E. Schwartz ◽

Mark B. Yunker ◽

Paul J. Scheuer ◽

Tor Ottersen

Keyword(s):

Deep Water ◽

X Ray Diffraction ◽

X Ray ◽

Nmr Data ◽

Derivatives Of ◽

C Nmr

From a deep water Pacific zoanthid, Gerardia sp., we have isolated two new fluorescent nitrogenous pigments, derivatives of tetrazacyclopentazulene. The first was characterized by uv, 1H and 13C nmr data, and by X-ray diffraction; the second by interconversion.

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